Neurology

Jeffrey R. Binder, MD

Professor of Neurology
Professor of Cellular Biology, Neurobiology and Anatomy
Professor of Biophysics
Director, Stroke and Neurobehavior Programs, Department of Neurology
Director, Language Imaging Laboratory, Department of Neurology
Interim Director, Functional Imaging Research Center

Specialty: Adult Neurology

Sub-Specialty:

• Aphasia
• Behavioral Neurology
• Cerebrovascular Disease
• Neuroimaging
• Neuropsychology

Education:

• Doctor of Medicine, University of Nebraska College of Medicine, Omaha, 1986

Training:

• Residency, Internal Medicine, Northwestern University Medical School, Chicago, IL, 1987
• Resident, Neurology, The Neurological Institute of New York, Presbyterian Hospital; New York, NY, 1987-1990
• Fellow, Stroke and Behavioral Neurology, The Neurological Institute of New York, Presbyterian Hospital; New York, NY, 1990-1992

Societies:

• American Academy of Neurology, 1987
• American Association for the Advancement of Science, 1993
• International Society for Magnetic Resonance in Medicine, 1995
• Society for Neuroscience, 1995
• World Federation of Neurology - Research Group on Aphasia and Cognitive Disorders, 1996
• Cognitive Neuroscience Society, 1997

Awards/Honors:

• Graduation with High Distinction, University of Nebraska, 1980
• Phi Beta Kappa, 1980
• Regents Scholarship, Universtiy of Nebraska Medical Center, 1983
• Michaelson Student Research Grant, University of Nebraska Medical Center, 1985
• Alpha Omega Alpha, 1985

Brief Clinical/Research Interest Statement:

"Functional Magnetic Resonance Imaging of the Brain," NIMH P01 MH51358-01A1 (Co-Investigator).

"Functional MRI of Human Brain Language Systems," NINDS RO1 NS33576-06 (J.R. Binder, P.I.).

"Functional Magnetic Resonance Imaging During Auditory Language Processing," McDonnell-Pew Program in Cognitive Neuroscience, Grant No. 92-35. Total Direct Costs (1993-1995).  20% effort; Principal Investigator.

"Effects of Stimulus Rate, Intensity, and Duration on Functional Magnetic Resonance Signal Response," Medical College of Wisconsin Research Affairs Committee, Grant No. 1093-11.  Total funding.  Principal Investigator.

"Natural History of Neurobehavioral Dysfunction in MS," National Multiple Sclerosis Society Grant (S.M. Rao, P.I.).  Total Direct Costs (1994-1997).  5% effort; Co-Investigator.

"Pre-surgical Localization of Language and Memory Cortex with Functional MRI," Charles A. Dana Foundation Clinical Hypotheses in Neuroscience Research Program. Direct Costs (1994-1997). 14% effort; Principal Investigator.

"A Multicenter, Double-Blind, Placebo-Controlled, Dose-Finding Efficacy Study of CNS 1102 in Patients with Acute Cerebral Ischemia," Cambridge Neuroscience, Inc.  Total local costs (1995).  5% effort; Local Principal Investigator.

"Phase II/III Multicenter, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Two Doses of Intravenous Aptiganel Hydrochloride versus Placebo in Patients with Acute Ischemic Stroke," Boehringer Ingelheim, Inc.  Total local costs (1996-1997).  5% effort; Local Principal Investigator.

"Clomethiazole Acute Stroke Study (CLASS-I, II, III)," Astra Pharmaceuticals, Inc. (Co-Investigator). 
 

Publications:

Original Publications

1. Sun SF, Binder JR, Streib E, Goodlin RC.  Myotonic dystrophy: Obstetric and neonatal complications.  Southern Medical Journal, 1985; 78(7): 823-26.
2. Chamorro A, Sacco RL, Ciecierski K, Binder JR, Tatemichi TK, Mohr JP.  Visual hemineglect and hemihallucinations in a patient with subcortical infarction. Neurology, 1990; 40: 1463-64.
3. Binder JR, Lazar RM, Tatemichi TK, Mohr JP, Desmond DW, Ciecierski KA.  Left hemiparalexia. Neurology, 1992; 42: 562-569.
4. Binder JR, Marshall RS, Lazar RM, Benjamin JL, Mohr JP.  Distinct syndromes of hemineglect. Archives of Neurology, 1992; 49: 1187-1194.
5. Binder JR, Mohr JP.  The topography of callosal reading pathways: A case-control analysis. Brain, 1992; 115: 1807-1826.
6. Rao SM, Binder JR, Bandettini PA, Hammeke TA, Yetkin FZ, Jesmanowicz A, Lisk LM, Morris GL, Mueller WM, Estkowski LD, Wong EC, Haughton VM, Hyde JS.  Functional magnetic resonance imaging of complex human movements. Neurology, 1993, 43: 2311-2318.
7. Binder JR, Rao SM, Hammeke TA, Yetkin FZ, Jesmanowicz A, Bandettini PA, Wong EC, Estkowski LD, Goldstein MD, Haughton VM, Hyde JS.  Functional magnetic resonance imaging of human auditory cortex.  Annals of Neurology, 1994; 35: 662-672.
8. Binder JR, Rao SM, Hammeke TA, Bandettini PA, Frost JA, Hyde JS.  Effects of stimulus rate on signal response during functional magnetic resonance imaging of auditory cortex.  Cognitive Brain Research, 1994; 2: 31-38.
9. Marshall RS, Lazar RM, Binder JR, Desmond DW, Drucker PM, Mohr JP.  Intrahemispheric localization of drawing dysfunction. Neuropsychologia, 1994; 32: 493-501.
10. Hammeke TA, Yetkin FZ, Mueller WM, Morris GL, Haughton VM, Rao SM, Binder JR.  Functional magnetic resonance imaging of somatosensory stimulation. Neurosurgery. 1994; 35: 677-681.
11. Binder JR, Rao SM, Hammeke TA, Frost JA, Bandettini PA, Jesmanowicz A, Hyde JS.  Lateralized human brain language systems demonstrated with task subtraction functional magnetic resonance imaging.  Archives of Neurology, 1995; 52: 593-601.
12. Rao SM, Binder JR, Hammeke TA, Bandettini PA, Bobholz JA, Frost JA, Myklebust BM, Jacobson RD, Hyde JS.  Somatotopic mapping of the human primary motor cortex with functional magnetic resonance imaging. Neurology, 1995; 45: 919-924.
13. Binder JR, Swanson SJ, Hammeke TA, Morris GL, Mueller WM, Fischer M, Benbadis S, Frost JA, Rao SM, Haughton VM.  Determination of language dominance using functional magnetic resonance imaging: A comparison with the Wada test. Neurology, 1996; 46: 978-984.
14. Rao SM, Bandettini PA, Binder JR, Bobholz JA, Hammeke TA, Stein EA, Hyde JS.  Relationship between movement rate and functional magnetic resonance signal change in human primary motor cortex. Journal of Cerebral Blood Flow and Metabolism, 1996; 16: 1250-1254.
15. Binder JR, Frost JA, Hammeke TA, Rao SM, Cox RW.  Function of the left planum temporale in auditory and linguistic processing. Brain, 1996; 119: 1239-1247.
16. Binder JR, Frost JA, Hammeke TA, Cox RW, Rao SM, Prieto T.  Human brain language areas identified by functional magnetic resonance imaging. Journal of Neuroscience, 1997; 17: 353-362.
17. Rao SM, Bobholz JA, Hammeke TA, Rosen AC, Woodley SJ, Cunningham JM, Cox RW, Stein EA, Binder JR.  Functional MRI evidence for subcortical participation in conceptual reasoning skills.  Neuroreport, 1997; 8: 1987-1993.
18. Rao SM, Harrington DL, Haaland KY, Bobholz JA, Cox RW, Binder JR.  Distributed neural systems underlying the timing of movements.  Journal of Neuroscience, 1997; 17: 5528-5535.
19. Arnett PA, Rao SM, Bernardin L, Luchetta T, Binder JR, Lobeck L.  Executive functions in multiple sclerosis: an analysis of temporal ordering, semantic encoding, and planning abilities. Neuropsychology, 1997; 11: 535-544.
20. Bellgowan PSF, Binder JR, Swanson SJ, Hammeke TA, Springer JA, Frost JA, Mueller WM, Morris GL.  Side of seizure focus determines left medial temporal lobe activation during verbal encoding.  Neurology, 1998; 51: 479-484.
21. Benbadis SR, Binder JR, Swanson SJ, Fischer M, Hammeke TA, Morris GL, Frost JA, Springer JA.  Is speech arrest during Wada testing a valid method for determining hemispheric representation of language? Brain and Language, 1998; 65: 441-446.
22. Binder JR, Frost JA, Hammeke TA, Bellgowan PSF, Rao SM, Cox RW.  Conceptual processing during the conscious resting state: a functional MRI study.  Journal of Cognitive Neuroscience, 1999; 11: 80-93.
23. Rosen AC, Rao SM, Caffarra P, Scaglioni A, Bobholz JA, Woodley SJ, Hammeke TA, Cunningham JM, Binder JR.  Neural basis of endogenous and exogenous spatial orienting: a functional MRI study.  Journal of Cognitive Neuroscience, 1999; 11: 135-152.
24. Frost JA, Binder JR, Springer JA, Hammeke TA, Bellgowan PSF, Rao SM, Cox RW.  Language processing is strongly left lateralized in both sexes: Evidence from FMRI.  Brain, 1999; 122: 199-208.
25. Crosson B, Rao SM, Woodley SJ, Rosen AC, Hammeke TA, Bobholz JA, Mayer A, Cunningham JM, Fuller SA, Binder JR, Cox RW, Stein EA.  Mapping of semantic, phonological, and orthographic verbal working memory in normal adults with FMRI.  Neuropsychology, 1999; 13: 171-187.
26. Tanne D, Bates VE, Verro P, Kasner SE, Binder JR, Patel SC, Mansbach HH, Daley S, Schultz LR, Karanjia PN, Scott P, Dayno JM, Vereczkey-Porter K, Benesch C, Book D, Coplin WM, Dulli D, Levine SR, et al.  Initial clinical experience with IV tissue plasminogen activator for acute ischemic stroke: A multicenter survey.  Neurology, 1999; 53: 424-427.
27. Springer JA, Binder JR, Hammeke TA, Swanson SJ, Frost JA, Bellgowan PS, Brewer CC, Perry HM, Morris GL, Mueller WM.  Language dominance in neurologically normal and epilepsy subjects: a functional MRI study. Brain, 1999; 122: 2033-2045.
28. Leveroni CL, Seidenberg M, Mayer AR, Mead LA, Binder JR, Rao SM.  Neural systems underlying the recognition of familiar and newly learned faces.  Journal of Neuroscience, 2000; 20: 878-886.
29. Tanne D, Gorman MJ, Bates VE, Kasner SE, Scott P, Verro P, Binder JR, Dayno JM, Schultz LR, Levine SR, et al.  Intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 80 years and older. The tPA stroke survey experience.  Stroke, 2000; 31: 370-375.
30. Harrington DL, Rao SM, Haaland KY, Bobholz JA, Mayer AR, Binder JR, Cox RW.  Specialized neural systems underlying representations of sequential movements.  Journal of Cognitive Neuroscience, 2000; 12: 56-77.
31. Binder JR, Frost JA, Hammeke TA, Bellgowan PSF, Springer JA, Kaufman JN, Possing ET.  Human temporal lobe activation by speech and nonspeech sounds.  Cerebral Cortex, 2000; 10: 512-528.
32. Alsaadi T, Binder JR, Lazar RM, Doorani T, Mohr JP.  Pure topographical disorientation: A distinctive syndrome with varied localization. Neurology, 2000; 54: 1864-1866.
33. Demchuk AM, Tanne D, Hill MD, Kasner SE, Hanson S, Grond M, Levine SR, and the Multicenter tPA Stroke Survey Group.  Predictors of good outcome after intravenous rt-PA for acute ischemic stroke: The multi-centre tPA acute stroke survey. Submitted to Stroke.

Books, Chapters and Reviews:

1. Binder JR, Rao SM.  Brain mapping with functional magnetic resonance imaging.  In: Localization and Neuroimaging in Neuropsychology, Kertesz A, ed.  Orlando, Academic Press, 1994, p.185-212.
2. Binder JR.  Functional magnetic resonance imaging of language cortex. International Journal of Imaging Systems and Technology, 1995; 6: 280-288.
3. Bandettini PA, Wong EC, Binder JR, Rao SM, Jesmanowicz A, Aaron E, Lowry T, Forster H, Hinks RS, Hyde JS.  Functional MRI using the BOLD approach: Dynamics and data analysis techniques.  In: Perfusion and Diffusion: Magnetic Resonance Imaging, LeBihan D, Rosen B, eds.  New York, Raven Press, 1995, p.335-349.
4. Bandettini PA, Binder JR, DeYoe EA, Rao SM, Hammeke TA, Jesmanowicz A, Wong EC, Haughton VM, Hyde JS.  Functional MRI using the BOLD approach: Applications.  In: Perfusion and Diffusion: Magnetic Resonance Imaging, LeBihan D, Rosen B, eds.  New York, Raven Press, 1995, p.351-362.
5. Bandettini PA, Binder JR, DeYoe EA, Hyde JS.  Brain: Sensory activation-induced hemodynamic changes observed in the human brain with echo planar MRI.  In: Encyclopedia of NMR, Vol. 1, Grant DM, Harris RK, eds.  New York; John Wiley & Sons, 1996, p. 1051-1056.
6. Binder JR.  Neuroanatomy of language processing studied with functional MRI.  Clinical Neuroscience, 1997; 4: 87-94.
7. Binder J.  Functional Magnetic Resonance Imaging: Language mapping. Neurosurgery Clinics of North America, 1997; 8: 383-392.
8. Binder JR, Frost JA.  Functional MRI studies of language processes in the brain.  Neuroscience News, 1998; 1: 15-23.
9. Jaradeh S, Braun T, Maas E, Lobeck L, Antuono P, Binder J, Terry LC.  Neurologic disorders.  In: Kochar's Concise Textbook of Medicine, 3rd Edition. Baltimore, MD; Williams and Wilkins, 1998.
10. Binder, JR.  Functional MRI of the language system.  In: Functional MRI, Moonen CTW, Bandettini PA, eds.  Berlin, Springer-Verlag, 1999, p.407-419.
11. Zatorre RR, Binder JR. The human auditory system. In: Brain Mapping: The Systems, Toga AW, Mazziotta JC, eds. San Diego, CA; Academic Press, 2000, p. 365-402.
12. Hammeke TA, Bellgowan PSF, Binder JR.  FMRI: Methodology: Cognitive function mapping.  In: Functional Imaging in the Epilepsies; Henry TR, Duncan JS, Berkovic SF, eds.  Philadelphia; Lippincott Williams & Wilkins, in press.
13. Binder J, Price C.  Functional imaging of language. In: Handbook on Functional Neuroimaging of Cognition, Cabeza R, Kingstone A, eds. Cambridge, MA; MIT Press, in press.
14. Binder JR.  The Wernicke-Lichtheim model of language processing.  In: The Corsini Encyclopedia of Psychology and Neuroscience, Craighead WE, Nemeroff CB, eds. New York, John Wiley & Sons, in press.