Neurology

John Lynch, MD, FAHA

Associate Professor of Neurology

Specialty: Adult Neurology

Areas of Expertise:

• Acute Stroke Therapy
• Arterial Venous Malformation of the Brain & Spine
• Brain Aneurysm
• Carotid Artery Disease
• Endovascular Neurosurgery
• Interventional Neuroradiology
• Intracranial Angioplasty and Stenting
• Pre-Operative Embolization of Head, Neck & Spine Tumors
• Stroke, Cerebral Aneurysms and Brain Hemorrhage
• Hereditary Hemorrhagic Telangiectasia (HHT)

Education:

• Doctor of Medicine, Duke University School of Medicine, Durham, 1994

Training:

• Internship, Medicine, Duke University Medical Center, Durham, 1994-1995
• Residency, Medicine/Neurology, Duke University Medical Center, Durham, 1995-1999
• Fellow, NICU/Stroke, Duke University Medical Center, Durham, 1999-2002

Brief Clinical/Research Statement

• Stroke
• Inflammatory mediators in acute CNS injury
• Apolipoprotein E and the CNS response to injury
• Subarachnoid hemorrhage and Traumatic Brain injury clinical trials
• Hypothermic neuroprotection
• Biochemical surrogates of CNS Injury

Selected Publications

• Lynch JR, Wang H, McGirt MJ, Floyd J, Friedman AH, Coon AL, Blessing R, Alexander MJ, Graffagnino C, Warner DS, Laskowitz DT. “Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial.” Stroke. 2005 Sep;36(9):2024-6.
• Lynch JR, Wang H, Mace B, Leinenweber, S, Warner DS, Bennett ER, Vitek MP, McKenna, S, Laskowitz, DT, “A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury.” Experimental Neurology 192(1):109-16. 2005
• Mathew JP, Grocott HP, McCurdy JR, Ti LK, Davis RD, Laskowitz DT, Podgoreanu MV, Swaminathan M, Lynch JR, Stafford-Smith M, White WD, Newman MF. “Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass.”J Cardiothorac Vasc Anesth. 2005 Jun;19(3):294-9.
• Laskowitz DT, Blessing R, Floyd J, White WD, Lynch JR. “Panel of biomarkers predicts stroke.” Ann N Y Acad Sci. 2005 Aug;1053:30.
• Leinenweber SB, Sheng H, Lynch JR, Wang H, Batinic-Haberle I, Laskowitz DT, Crapo JD, Pearlstein RD, Warner DS. Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. Eur J Pharmacol. 2006 Feb 15;531(1-3):126-32.
• Gao J, Wang H, Sheng H, Lynch JR, Warner DS, Durham L, Vitek MP, Laskowitz DT. “A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.” Neurocrit Care. 2006;4(1):25-31
• McGirt MJ, Woodworth GF, Pradilla G, Legnani F, Warner D, Tamargo R, Clatterbuck R, Lynch JR, Laskowitz DT. “Simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase.” Clin Neurosurg. 2005;52:371-3
• Wang H, Gao J, Lassiter TF, McDonagh DL, Sheng H, Warner DS, Lynch JR, Laskowitz DT. “Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage.” Neurocrit Care. 2006;5(1):71-8.
• McGirt MJ, Blessing R, Alexander MJ, Nimjee SM, Woodworth GF, Friedman AH, Graffagnino C, Laskowitz DT, Lynch JR. “Risk of cerebral vasopasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experience.” J Neurosurg. 2006 Nov;105(5):671-4.
• Wang H, Lynch JR, Song P, Yang HJ, Yates RB, Mace B, Warner DS, Guyton JR, Laskowitz DT. “Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.” Exp Neurol. 2007 Apr 27.