EmailEmail    |   Bookmark Page Bookmark  |   RSS Feeds RSS  |   Print Page Print  

John LynchJohn Lynch, MD, FAHA

Associate Professor of Neurology
Director, Neuroscience Service Line
Director, Neuroscience Intensive Care Unit (NICU)
Fellowship Director, Neurocritical Care


Specialty: Adult Neurology

Areas of Expertise:

  • Acute Stroke Therapy
  • Arterial Venous Malformation of the Brain & Spine
  • Brain Aneurysm
  • Carotid Artery Disease
  • Endovascular Neurosurgery
  • Interventional Neuroradiology
  • Intracranial Angioplasty and Stenting
  • Pre-Operative Embolization of Head, Neck & Spine Tumors
  • Stroke, Cerebral Aneurysms and Brain Hemorrhage
  • Hereditary Hemorrhagic Telangiectasia (HHT)


  • Doctor of Medicine, Duke University School of Medicine, Durham, 1994


  • Internship, Medicine, Duke University Medical Center, Durham, 1994-1995
  • Residency, Medicine, Duke University Medical Center, Durham, 1995-1999
  • Residency, Neurology, Duke University Medical Center, Durham, 1995-1999
  • Fellow, Stroke and Cerebrovascular Disease, Duke University Medical Center, Durham, 1999-2000
  • Fellow, Neurocritical Care, Duke University Medical Center, Durham, 2000-2002
  • Fellow, Endovascular Surgical Neuroradiology, Medical College of WI, Milwaukee, 2006-2008

Board Certification:

  • American Board of Internal Medicine
  • American Board of Neurology and Psychiatry
  • Vascular Neurology
  • Neurocritical Care

Brief Clinical/Research Statement

  • Stroke
  • Inflammatory mediators in acute CNS injury
  • Apolipoprotein E and the CNS response to injury
  • Subarachnoid hemorrhage and Traumatic Brain injury clinical trials
  • Hypothermic neuroprotection
  • Biochemical surrogates of CNS Injury

Selected Publications:

  1. Lazzaro MA, Badruddin A, Zaidat OO, Darkhabani Z, Pandya DJ, Lynch JR. Endovascular embolization of head and neck tumors. Front Neurol 2011;2:64 PMID 22022319
  2. Zaidat OO, Lazzaro MA, Niu T, Hong SH, Fitzsimmons BF, Lynch JR, Sinson GP. Multimodal endovascular therapy of traumatic and spontaneous carotid cavernous fistula using coils, n-BCA, Onyx and stent graft. J Neurointerv Surg 2011 Sep;3(3):255-62 PMID 21990837
  3. Dawson HN, Cantillana V, Jansen M, Wang H, Vitek MP, Wilcock DM, Lynch JR, Laskowitz DT. Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. Neuroscience 2010 Aug 11;169(1):516-31 PMID 20434528
  4. Wolfe TJ, Fitzsimmons BF, Hussain SI, Lynch JR, Zaidat OO. Long term clinical and angiographic outcomes with the Wingspan stent for treatment of symptomatic 50-99% intracranial atherosclerosis: single center experience in 51 cases. J Neurointerv Surg 2009 Jul;1(1):40-3 PMID 21994104
  5. Hussain SI, Lynch JR, Wolfe T, Fitzsimmons BF, Zaidat OO. Stent-assisted parent artery occlusion of giant cerebrovascular aneurysms to avoid mass effect. J Neuroimaging 2009 Oct;19(4):370-4 PMID 19453830
  6. Hussain SI, Wolfe TJ, Lynch JR, Fitzsimmons BF, Zaidat OO. Diagnostic cerebral angiography: the interventional neurology perspective. J Neuroimaging 2010 Jul;20(3):251-4 PMID 19226341
  7. Wolfe TJ, Hussain SI, Lynch JR, Fitzsimmons BF, Zaidat OO. Pediatric cerebral angiography: analysis of utilization and findings. Pediatr Neurol 2009 Feb;40(2):98-101 PMID 19135622
  8. Pandya DJ, Fitzsimmons BF, Wolfe TJ, Hussain SI, Lynch JR, Ortega-Gutierrez S, Zaidat O. Measurement of antiplatelet inhibition during neurointerventional procedures: the effect of antithrombotic duration and loading dose. J Neuroimaging 2010 Jan;20(1):64-9 PMID 19018951
  9. Zaidat OO, Wolfe T, Hussain SI, Lynch JR, Gupta R, Delap J, Torbey MT, Fitzsimmons BF. Interventional acute ischemic stroke therapy with intracranial self-expanding stent. Stroke 2008 Aug;39(8):2392-5 PMID 18556584
  10. Lemke DM, Hussain SI, Wolfe TJ, Torbey MA, Lynch JR, Carlin A, Fitzsimmons BF, Zaidat OO. Takotsubo cardiomyopathy associated with seizures. Neurocrit Care 2008;9(1):112-7 PMID 18347760
  11. Wang H, Lynch JR, Song P, Yang HJ, Yates RB, Mace B, Warner DS, Guyton JR, Laskowitz DT Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol 2007 Jul;206(1):59-69 PMID 17521631
  12. Mace BE, Wang H, Lynch JR, Moss J, Sullivan P, Colton H, Morgan K, Renauld JC, Laskowitz DT. Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway. Neurol Res 2007 Apr;29(3):243-50 PMID 17509222
  13. McGirt MJ, Blessing R, Alexander MJ, Nimjee SM, Woodworth GF, Friedman AH, Graffagnino C, Laskowitz DT, Lynch JR. Risk of cerebral vasospasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experience. J Neurosurg 2006 Nov;105(5):671-4 PMID 17121126
  14. Wang H, Gao J, Lassiter TF, McDonagh DL, Sheng H, Warner DS, Lynch JR, Laskowitz DT. Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage. Neurocrit Care 2006;5(1):71-8 PMID 16960300
  15. McGirt MJ, Woodworth GF, Pradilla G, Legnani F, Warner D, Tamargo R, Clatterbuck R, Lynch JR, Laskowitz DT. Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase. Clin Neurosurg 2005;52:371-8 PMID 16626096
  16. Gao J, Wang H, Sheng H, Lynch JR, Warner DS, Durham L, Vitek MP, Laskowitz DT. A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage. Neurocrit Care 2006;4(1):25-31 PMID 16498192
  17. Leinenweber SB, Sheng H, Lynch JR, Wang H, Batinić-Haberle I, Laskowitz DT, Crapo JD, Pearlstein RD, Warner DS. Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. Eur J Pharmacol 2006 Feb 15;531(1-3):126-32 PMID 16455070
  18. Laskowitz DT, Blessing R, Floyd J, White WD, Lynch JR. Panel of biomarkers predicts stroke. Ann N Y Acad Sci 2005 Aug;1053:30 PMID 16179504
  19. Olson DM, Graffagnino C, King K, Lynch JR. Toward solving the sedation-assessment conundrum: bi-spectral index monitoring and sedation interruption. Crit Care Nurs Clin North Am 2005 Sep;17(3):257-67 PMID 16115534
  20. Lynch JR, Wang H, McGirt MJ, Floyd J, Friedman AH, Coon AL, Blessing R, Alexander MJ, Graffagnino C, Warner DS, Laskowitz DT. Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial. Stroke 2005 Sep;36(9):2024-6 PMID 16051891
  21. Lynch JR, Wang H, Mace B, Leinenweber S, Warner DS, Bennett ER, Vitek MP, McKenna S, Laskowitz DT. A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. Exp Neurol 2005 Mar;192(1):109-16 PMID 15698624
  22. McGirt MJ, Woodworth GF, Lynch JR, Laskowitz DT. Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the treatment of neurological injury: a role beyond cholesterol lowering. Clin Neurosurg 2004;51:320-8 PMID 15571161
  23. Olson DM, Meek LG, Lynch JR. Accurate patient history contributes to differentiating diabetes insipidus: a case study. J Neurosci Nurs 2004 Aug;36(4):228-30 PMID 15366550
  24. McGirt MJ, Blessing R, Nimjee SM, Friedman AH, Alexander MJ, Laskowitz DT, Lynch JR. Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage. Neurosurgery 2004 Jun;54(6):1369-73; discussion 1373-4 PMID 15157293
  25. Elsersy H, Sheng H, Lynch JR, Moldovan M, Pearlstein RD, Warner DS. Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. Anesthesiology 2004 May;100(5):1160-6 PMID 15114213
  26. Lynch JR, Blessing R, White WD, Grocott HP, Newman MF, Laskowitz DT. Novel diagnostic test for acute stroke. Stroke 2004 Jan;35(1):57-63 PMID 14671250
  27. Lynch JR, Tang W, Wang H, Vitek MP, Bennett ER, Sullivan PM, Warner DS, Laskowitz DT. APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. J Biol Chem 2003 Dec 5;278(49):48529-33 PMID 14507923
  28. McGirt MJ, Mavropoulos JC, McGirt LY, Alexander MJ, Friedman AH, Laskowitz DT, Lynch JR. Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. J Neurosurg 2003 Jun;98(6):1222-6 PMID 12816268
  29. Aono M, Bennett ER, Kim KS, Lynch JR, Myers J, Pearlstein RD, Warner DS, Laskowitz DT. Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures. Neuroscience 2003;116(2):437-45 PMID 12559098
  30. McGirt MJ, Lynch JR, Parra A, Sheng H, Pearlstein RD, Laskowitz DT, Pelligrino DA, Warner DS. Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. Stroke 2002 Dec;33(12):2950-6 PMID 12468796
  31. McGirt MJ, Lynch JR, Blessing R, Warner DS, Friedman AH, Laskowitz DT. Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurgery 2002 Nov;51(5):1128-34; discussion 1134-5 PMID 12383357
  32. Lynch JR, Pineda JA, Morgan D, Zhang L, Warner DS, Benveniste H, Laskowitz DT. Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol 2002 Jan;51(1):113-7 PMID 11782990
  33. Lynch JR, Morgan D, Mance J, Matthew WD, Laskowitz DT. Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol 2001 Mar 1;114(1-2):107-13 PMID 11240021
  34. Bushnell CD, Phillips-Bute BG, Laskowitz DT, Lynch JR, Chilukuri V, Borel CO. Survival and outcome after endotracheal intubation for acute stroke. Neurology 1999 Apr 22;52(7):1374-81 PMID 10227620
  35. Morgenlander JC, Lynch JR, Sanders DB. Surgical treatment of carpal tunnel syndrome in patients with peripheral neuropathy. Neurology 1997 Oct;49(4):1159-63 PMID 9339710
  36. Endovascular reconstruction for progressively worsening carotid artery dissection.
    Asif KS, Lazzaro MA, Teleb MS, Fitzsimmons BF, Lynch J, Zaidat O. J Neurointerv Surg. 2014 Jan 3
  37. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial. Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators. Lancet. 2014 Jan 25;383(9914):333-41. doi: 10.1016/S0140-6736(13)62038-3. Epub 2013 Oct 26
  38. Safety and predictors of aneurysm retreatment for remnant intracranial aneurysm after initial endovascular embolization.
    Teleb MS, Pandya DJ, Castonguay AC, Eckardt G, Sweis R, Lazzaro MA, Issa MA, Fitzsimmons BF, Lynch JR, Zaidat OO.
    J Neurointerv Surg. 2013 Aug 16
  39. Vascular neurologists and neurointerventionalists on endovascular stroke care: polling results. Nguyen TN, Zaidat OO, Edgell RC, Janjua N, Yavagal DR, Xavier AR, Kirmani JF, Liebeskind DS, Nogueira RG, Vora NA, Sims JR, Lynch JR, Fitzsimmons BF, Wolfe TJ, Chen M, Badruddin A, Zahuranec DB, McDonagh DL, Janardhan V, Bastan B, Madden JA, Sanossian N, Gupta R, Lazzaro MA, Jovin TG, Abou-Chebl A, Linfante I, Hussain SI. Neurology. 2012 Sep 25;79(13 Suppl 1):S5-15
  40. Complications of endovascular therapy for acute ischemic stroke and proposed management approach.
    Darkhabani Z, Nguyen T, Lazzaro MA, Zaidat OO, Lynch JR, Fitzsimmons BF, Linfante I. Neurology. 2012 Sep 25;79(13 Suppl 1):S192-8.
© 2014 Medical College of Wisconsin
Page Updated 06/17/2014