Neurology

Paul E. Barkhaus, MD

Professor of Neurology and Professor of Physical Medicine & Rehabilitation
Section Chief, Neuromuscular and Autonomic Disorders
Director, Amyotrophic Lateral Sclerosis Program (ALS Association Certified Center of Excellence)
Director, Clinical Neurophysiology Residency

Specialty: Adult Neurology

Sub-Specialty:

• Amyotrophic Lateral Sclerosis
• Electromyography
• Neuromuscular Disease

Education:

• Doctor of Medicine, Wayne State University School of Medicine, Detroit, MI, 1975

Training:

• Resident, Department of Neurology, Wayne State University, Detroit, Michigan, 1975-1978
• Electromyography Fellowship, Department of Neurology, University of Minnesota, Minneapolis, Minnesota, 1978-1979
• Clinical Neuromuscular Diseases Fellowship, Department of Neurology, University of Arizona, Tucson, Arizona, 1979-1980
• Single Fiber Electromyography, Uppsala University, Uppsala, Sweden, 1980
• Visiting Scientist, November, Department of Clinical Neurophysiology Uppsala University, Uppsala, Sweden, 1985-1986
• Senior Research Fellowship in Electromyography, Duke University Medical Center, Durham, North Carolina, 1986-1987

Board Certification:

• American Board of Psychiatry and Neurology
• American Board of Electrodiagnostic Medicine

Societies:

• American Academy of Neurology (Fellow)
• American Neurological Association
• American Association of Electromyography and Electrodiagnosis (Fellow)
• Wisconsin Neurological Society (Past President, 2000-2001)

Awards/Honors:

• Distinguished Service Award, Wayne State University School of Medicine, 1975
• Trainee Award, Federation of Western Societies of Neurological Sciences, 1980
• Special Commendation, Minnesota Chapter, Myasthenia Gravis Foundation, 1983
• Special Commendation, Cincinnati Chapter, Muscular Dystrophy Association, 1983
• Alumnus Hall of Fame, Allen Park High School, Allen Park, Michigan, 1987
• Distinguished Visitor to USS Theodore Roosevelt, by invitation of Commander, U.S. 2nd Fleet, 2000
• Clinical Neurophysiology Teacher of The Year, Department of Neurology, Medical College of Wisconsin, 2001 and 2010
• Selected for inclusion to "America's Top Physicians", Consumers' Research Council of America, 2006
• Elected to Active Membership, American Neurological Association
• Selected for inclusion in "Best Doctors^®" (2005- )
• Special Commendation by Paralyzed Veterans of America for Advocacy in Veterans with ALS, 2010

Brief Clinical/Research Interest Statement:

Clinical Interests:

• Amyotrophic Lateral Sclerosis
• Quantitative Electromyography

Research Interests:

• Drug Trials in Patients with ALS (one active)
• Motor Unit Number Indexing
• Compound Muscle Action Potentials

Publications:

Original Publications

1. Zucca C, Binda S, Borgatti R, Triulzi F, Radice L, Barkhaus PE, Barbi M: Congenital Cytomegalovirus Infection and Cortical Maldevelopment: A Retrospective Diagnosis. Neurology 61 (11): 710-712, 2003.
2. Nandedkar SD, Nandedkar D, Stalberg EV,  Barkhaus PE: Motor Unit Indexing (MUI): A new method to study the number of MUs.  IEEE Transactions in Biomedical Engineering, 2004; 51 (12):2209-2211.
3. Barkhaus PE, Collins MI, Nandedkar SD: Influence of the surface EMG electrode on the compound muscle action potential. Electromyography & Clinical Neurophysiology, 2006; 46:235-239.
4. Barkhaus PE, Roberts, MM, Nandedkar SD: "Facial" and standard concentric needle electrodes are not interchangeable. Electromyography & Clinical Neurophysiology, 2006; 46:259-261.
5. Barkhaus PE, Nandedkar SD: Serial quantitative electrophysiologic studies in sporadic inclusion body myositis. Electromyography & Clinical Neurophysiology, 2006; 47: 97-104.
6. Barkhaus PE, Nandedkar SD: Slow myotonia. Muscle Nerve, 2006; 34: 532-533.
7. Nandedkar SD, Barkhaus PE: Contribution of reference electrode to the compound muscle action potential. Muscle Nerve, 2007; 36:87-92.
8. Nandedkar SD, Barkhaus PE: Contribution of reference electrode to the compound muscle action potential.  Muscle Nerve, 2007; 36:87-92.
9. Sorenson eJ, Windebank AJ, Mandrekar JN, Bamiet WR, Appel SH, Armon C, Barkhaus PE, et al: Subcutaneous IGF-1 is not beneficial in 2-year ALS Trial.  Neurology 2008; 71:1770-1775.
10. Nandedkar SD, Barkhaus PE, Stalberg EV: Motor unit number index (MUNIX): principle, method and findings in healthy subjects and in patients with motor neuron disease.  Muscle Nerve, 2010; 42(5): 798-807.
11. Neuwirth C, Nandedkar SD, Stalberg EV, Barkhaus PE et al: A novel neurophysiological measurement (MUNIX) in neuromuscular disorders; test-retest reliability and longitudinal follow up measurements in healthy volunteers in a multicentre study.  Clinical Neurophysiol 2011; 122:1867-1872.
12. Barkhaus PE, Kincaid JC, Nandedkar SD: CMAP amplitude drop at the knee in tibial motor conduction studies.  Muscle Nerve 2011; in press.
13. Nandedkar SD, Barkhaus PE, Stalberg EV: Reproducibility of MUNIX in patients with amyotrophic lateral sclerosis.  Muscle Nerve 2011; in press.
14. Neuwirth C, Nandedkar SD, Stalberg EV, Barkhaus PE et al: Motor Unit Number Index (MUNIX): Reference values of five different muscles in healthy subjects from a multi-centre study.  Clinical Neurophysiol 2011, in press.
15. Zhou P, Barkhaus PE, Zhang X, Rymer WZ: Characterizing the complexity of spontaneous motor unit patterns of amyotrophic lateral sclerosis using approximate entropy.  Journal of Neural Engineer, 2011.

Books, Chapters and Reviews:

1. Nandedkar SD, Barkhaus PE: Quantitative EMG Analysis, in Katirji B, Kaminski HJ, Preston DC, Ruff RL, Shapiro BE: Neuromuscular Disorders in Clinical Practice. Boston, Butterworth-Heinemann, 2000.
2. Barkhaus PE: Kennedy's Disease.   In Lorenzo NY, Lutsep  HL (senior eds): eMedicine: Neurology. St. Petersberg, eMedicine Corp, 2001.
3. Barkhaus PE: Motor Unit Action Potential Quantitation. Workshop Handout. Rochester, MN, American Association of Electrodiagnostic Medicine, 2001, 2nd Edition.
4. Barkhaus PE, Nandedkar SD: EMG Evaluation of the Motor Unit: "The Electrophysiologic biopsy": Remodeling of the motor unit in neuromuscular  disorders.  In Lorenzo NY, Lutsep HL (senior eds): eMedicine: Neurology. St. Petersberg, eMedicine Corp, 2001.
5. Barkhaus PE: Motor unit action potential quantitation. Workshop Handout: & REVIEWS: American Association of Electrodiagnostic Medicine, Rochester, MN, 2001, 2nd Edition.
6. Nandedkar SD, Barkhaus PE: Quantitative Analysis: Objective & Interactive Assessment in EMG, in Bertorini (ed) Evaluation and Diagnostic Tests in Neuromuscular Disorders. Boston, Butterworth-Heinemann, 2002.
7. Barkhaus PE: The Electronic Myoanatomic Atlas for Clinical Electromyography. Hopewell Junction, NY, CASA Engineering, 2005, 2nd ed. (Book on multi-media DVD).
8. Collins MI, Collins MP, Barkhaus PE: Inclusion Body Myositis. In Quan D, Lorenzo NY, Lutsep HL (senior eds): eMedicine Journal (Neurology) [serial online]. 2005. Available at http://www.emedicine.com/neuro/topic422.htm.
9. Nandedkar SD, Barkhaus PE: Quantitative Analysis: Objective and Interactive Assessment in EMG, in Bertorini T (ed): Evaluation and Tests in Neuromuscular Disorders. Boston, Butterworth Heinnemann, 2002.
10. Nandedkar SD, Nandedkar, D, Stalberg EV, Barkhaus PE: Motor Unit Number Indexing (MUNIX): A pilot study. In Bromberg M: Motor Unit Number Estimation (MUNE): Supplements to Clinical Neurophysiology, Volume 55. New York, Elsevier, 2003, p 133-140.
11. Barboi AC, Barkhaus PE: Electrodiagnostic testing in neuromuscular disorders.  Neurol Clinics, 2004; 22(3): 619-640.
12. Barkhaus PE: Motor Nerve Conductions, Late Responses, and Reflexes. Hopewell Junction, NY, CASA Engineering, 2007, (Book on multi-media DVD).
13. Lin HC, Barkhaus PE: Cranial Nerve XII: The Hypoglossal Nerve.  Seminars in Neurology 2009; 29; 45-52.
14. Barkhaus PE:  Basic Myoanatomy in Electromyography with Needle Electrode Placement, in Amato AA, David W: Comprehensive Review of Electrodiagnostic medicine and Neuromuscular Disorders (Multi Media Presentation).  Oakstone Publishing/CMEinfo, 2012.