Neurology

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Paul E. BarkhausPaul E. Barkhaus, MD

Professor of Neurology and Professor of Physical Medicine & Rehabilitation
Section Chief, Neuromuscular and Autonomic Disorders
Director, Amyotrophic Lateral Sclerosis Program (ALS Association Certified Center of Excellence)
Director, Clinical Neurophysiology Residency

Specialty: Adult Neurology

Sub-Specialty:

  • Amyotrophic Lateral Sclerosis
  • Electromyography
  • Neuromuscular Disease

Education:

  • Doctor of Medicine, Wayne State University School of Medicine, Detroit, MI, 1975

Training:

  • Resident, Department of Neurology, Wayne State University, Detroit, Michigan, 1975-1978
  • Electromyography Fellowship, Department of Neurology, University of Minnesota, Minneapolis, Minnesota, 1978-1979
  • Clinical Neuromuscular Diseases Fellowship, Department of Neurology, University of Arizona, Tucson, Arizona, 1979-1980
  • Single Fiber Electromyography, Uppsala University, Uppsala, Sweden, 1980
  • Visiting Scientist, November, Department of Clinical Neurophysiology Uppsala University, Uppsala, Sweden, 1985-1986
  • Senior Research Fellowship in Electromyography, Duke University Medical Center, Durham, North Carolina, 1986-1987

Board Certification:

  • American Board of Psychiatry and Neurology
  • American Board of Electrodiagnostic Medicine

Societies:

  • American Academy of Neurology (Fellow)
  • American Neurological Association
  • American Association of Electromyography and Electrodiagnosis (Fellow)
  • Wisconsin Neurological Society (Past President, 2000-2001)

Awards/Honors:

  • Distinguished Service Award, Wayne State University School of Medicine, 1975
  • Trainee Award, Federation of Western Societies of Neurological Sciences, 1980
  • Special Commendation, Minnesota Chapter, Myasthenia Gravis Foundation, 1983
  • Special Commendation, Cincinnati Chapter, Muscular Dystrophy Association, 1983
  • Alumnus Hall of Fame, Allen Park High School, Allen Park, Michigan, 1987
  • Distinguished Visitor to USS Theodore Roosevelt, by invitation of Commander, U.S. 2nd Fleet, 2000
  • Clinical Neurophysiology Teacher of The Year, Department of Neurology, Medical College of Wisconsin, 2001 and 2010
  • Selected for inclusion to "America's Top Physicians", Consumers' Research Council of America, 2006
  • Elected to Active Membership, American Neurological Association
  • Selected for inclusion in "Best Doctors®" (2005- )
  • Special Commendation by Paralyzed Veterans of America for Advocacy in Veterans with ALS, 2010

Brief Clinical/Research Interest Statement:

Clinical Interests:

  • Amyotrophic Lateral Sclerosis
  • Quantitative Electromyography

Research Interests:

  • Drug Trials in Patients with ALS (one active)
  • Motor Unit Number Indexing
  • Compound Muscle Action Potentials

Publications:

Original Publications

  1. Nandedkar SD, Sheridan C, Bertoni S, Hiner BC, Barkhaus PE. Deep brain stimulator artifact in needle electromyography: effects and distribution in paraspinal and upper limb muscle. Muscle Nerve 2013 Apr;47(4):561-5 PMID 23463685
  2. Easterling C, Antinoja J, Cashin S, Barkhaus PE. Changes in Tongue Pressure, Pulmonary Function, and Salivary Flow in Patients with Amyotrophic Lateral Sclerosis. Dysphagia 2012 Dec 15: PMID 23242462
  3. Zhou P, Li X, Jahanmiri-Nezhad F, Rymer WZ, Barkhaus PE. Duration of observation required in detecting fasciculation potentials in amyotrophic lateral sclerosis using high-density surface EMG. J Neuroeng Rehabil 2012;9:78 PMID 23046668
  4. Zhou P, Barkhaus PE, Zhang X, Rymer WZ. Characterizing the complexity of spontaneous motor unit patterns of amyotrophic lateral sclerosis using approximate entropy. J Neural Eng 2011 Dec;8(6):066010 PMID 22049095
  5. Neuwirth C, Nandedkar SD, Stalberg EV, Barkhaus PE et al: A novel neurophysiological measurement (MUNIX) in neuromuscular disorders; test-retest reliability and longitudinal follow up measurements in healthy volunteers in a multicentre study.  Clinical Neurophysiol 2011; 122:1867-1872.
  6. Barkhaus PE, Kincaid JC, Nandedkar SD. Tibial motor nerve conduction studies: an investigation into the mechanism for amplitude drop of the proximal evoked response. Muscle Nerve 2011 Nov;44(5):776-82 PMID 22006693
  7. Nandedkar SD, Barkhaus PE, Stålberg EV. Reproducibility of MUNIX in patients with amyotrophic lateral sclerosis. Muscle Nerve 2011 Dec;44(6):919-22 PMID 21953206
  8. Neuwirth C, Nandedkar S, Stålberg E, Barkhaus PE, Carvalho Md, Furtula J, van Dijk JP, Baldinger R, Castro J, Costa J, Otto M, Sandberg A, Weber M. Motor Unit Number Index (MUNIX): reference values of five different muscles in healthy subjects from a multi-centre study. Clin Neurophysiol 2011 Sep;122(9):1895-8 PMID 21689981
  9. Neuwirth C, Nandedkar S, Stålberg E, Barkhaus PE, Carvalho Md, Furtula J, Dijk JP, Baldinger R, Castro J, Costa J, Otto M, Sandberg A, Weber M. Motor Unit Number Index (MUNIX): a novel neurophysiological marker for neuromuscular disorders; test-retest reliability in healthy volunteers. Clin Neurophysiol 2011 Sep;122(9):1867-72 PMID 21396884
  10. Nandedkar SD, Barkhaus PE, Stålberg EV. Motor unit number index (MUNIX): principle, method, and findings in healthy subjects and in patients with motor neuron disease. Muscle Nerve 2010 Nov;42(5):798-807 PMID 20976783
  11. Sorenson eJ, Windebank AJ, Mandrekar JN, Bamiet WR, Appel SH, Armon C, Barkhaus PE, et al. Subcutaneous IGF-1 is not beneficial in 2-year ALS trial. Neurology 2009 Oct 13;73(15):1247; author reply 1247-8 PMID 19822878
  12. Lin HC, Barkhaus PE. Cranial nerve XII: the hypoglossal nerve. Semin Neurol 2009 Feb;29(1):45-52 PMID 19214932
  13. Sorenson EJ, Windbank AJ, Mandrekar JN, Bamlet WR, Appel SH, Armon C, Barkhaus PE, Bosch P, Boylan K, David WS, Feldman E, Glass J, Gutmann L, Katz J, King W, Luciano CA, McCluskey LF, Nash S, Newman DS, Pascuzzi RM, Pioro E, Sams LJ, Scelsa S, Simpson EP, Subramony SH, Tiryaki E, Thornton CA. Subcutaneous IGF-1 is not beneficial in 2-year ALS trial. Neurology 2008 Nov 25;71(22):1770-5 PMID 19029516
  14. Barkhaus PE, Nandedkar SD. Serial quantitative electrophysiologic studies in sporadic inclusion body myositis. Electromyogr Clin Neurophysiol 2007 Mar-Apr;47(2):97-104 PMID 17479726
  15. Nandedkar SD, Barkhaus PE. Contribution of reference electrode to the compound muscle action potential. Muscle Nerve 2007 Jul;36(1):87-92 PMID 17455266
  16. Barkhaus PE, Nandedkar SD: Serial quantitative electrophysiologic studies in sporadic inclusion body myositis. Electromyography & Clinical Neurophysiology, 2006; 47: 97-104.
  17. Barkhaus PE, Nandedkar SD: Slow myotonia. Muscle Nerve, 2006; 34: 532-533.
  18. Barkhaus PE, Roberts MM, Nandedkar SD. "Facial" and standard concentric needle electrodes are not interchangeable. Electromyogr Clin Neurophysiol 2006 Sep;46(5):259-61 PMID 17059096
  19. Barkhaus PE, Periquet MI, Nandedkar SD. Influence of the surface EMG electrode on the compound muscle action potential. Electromyogr Clin Neurophysiol 2006 Jul-Aug;46(4):235-9 PMID 16929630
  20. Barkhaus PE, Nandedkar SD. "Slow" myotonic discharges. Muscle Nerve 2006 Dec;34(6):799-800 PMID 16927341
  21. Nandedkar SD, Nandedkar D, Stalberg EV,  Barkhaus PE: Motor Unit Indexing (MUI): A new method to study the number of MUs.  IEEE Transactions in Biomedical Engineering, 2004; 51 (12):2209-2211.
  22. Nandedkar SD, Nandedkar DS, Barkhaus PE, Stalberg EV. Motor unit number index (MUNIX). IEEE Trans Biomed Eng 2004 Dec;51(12):2209-11 PMID 15605872
  23. Barboi AC, Barkhaus PE. Electrodiagnostic testing in neuromuscular disorders. Neurol Clin 2004 Aug;22(3):619-41, vi PMID 15207878
  24. Zucca C, Binda S, Borgatti R, Triulzi F, Radice L, Barkhaus PE, Barbi M: Congenital Cytomegalovirus Infection and Cortical Maldevelopment: A Retrospective Diagnosis. Neurology 61 (11): 710-712, 2003.
  25. Zucca C, Binda S, Borgatti R, Triulzi F, Radice L, Buttè C, Barkhaus PE, Barbi M. Retrospective diagnosis of congenital cytomegalovirus infection and cortical maldevelopment. Neurology 2003 Sep 9;61(5):710-2 PMID 12963772
  26. Nandedkar SD, Barkhaus PE, Sanders DB, Stalberg EV. Some observations on fibrillations and positive sharp waves. Muscle Nerve 2000 Jun;23(6):888-94 PMID 10842264
  27. Barkhaus PE, Periquet MI, Nandedkar SD. Quantitative electrophysiologic studies in sporadic inclusion body myositis. Muscle Nerve 1999 Apr;22(4):480-7 PMID 10204783
  28. Moseley ML, Benzow KA, Schut LJ, Bird TD, Gomez CM, Barkhaus PE, Blindauer KA, Labuda M, Pandolfo M, Koob MD, Ranum LP. Incidence of dominant spinocerebellar and Friedreich triplet repeats among 361 ataxia families. Neurology 1998 Dec;51(6):1666-71 PMID 9855520
  29. Petit J, Barkhaus PE. Evaluation and management of polyneuropathy: a practical approach. Nurse Pract 1997 May;22(5):131-3, 136-8, 141-3 passim PMID 9172239
  30. Barkhaus PE, Periquet MI, Nandedkar SD. Quantitative motor unit action potential analysis in paraspinal muscles. Muscle Nerve 1997 Mar;20(3):373-5 PMID 9052821
  31. Barkhaus PE, Nandedkar SD. On the selection of concentric needle electromyogram motor unit action potentials: is the rise time criterion too restrictive? Muscle Nerve 1996 Dec;19(12):1554-60 PMID 8941269
  32. Nandedkar SD, Barkhaus PE, Charles A. Multi-motor unit action potential analysis (MMA) Muscle Nerve 1995 Oct;18(10):1155-66 PMID 7659110
  33. Barkhaus PE, Nandedkar SD. Recording characteristics of the surface EMG electrodes. Muscle Nerve 1994 Nov;17(11):1317-23 PMID 7935554
  34. Barkhaus PE, Nandedkar SD, Sanders DB. Quantitative EMG in inflammatory myopathy. Muscle Nerve 1990 Mar;13(3):247-53 PMID 2320046

 

 

Books, Chapters and Reviews:

  1. Nandedkar SD, Barkhaus PE: Quantitative EMG Analysis, in Katirji B, Kaminski HJ, Preston DC, Ruff RL, Shapiro BE: Neuromuscular Disorders in Clinical Practice. Boston, Butterworth-Heinemann, 2000.
  2. Barkhaus PE: Kennedy's Disease.   In Lorenzo NY, Lutsep  HL (senior eds): eMedicine: Neurology. St. Petersberg, eMedicine Corp, 2001.
  3. Barkhaus PE: Motor Unit Action Potential Quantitation. Workshop Handout. Rochester, MN, American Association of Electrodiagnostic Medicine, 2001, 2nd Edition.
  4. Barkhaus PE, Nandedkar SD: EMG Evaluation of the Motor Unit: "The Electrophysiologic biopsy": Remodeling of the motor unit in neuromuscular  disorders.  In Lorenzo NY, Lutsep HL (senior eds): eMedicine: Neurology. St. Petersberg, eMedicine Corp, 2001.
  5. Barkhaus PE: Motor unit action potential quantitation. Workshop Handout: & REVIEWS: American Association of Electrodiagnostic Medicine, Rochester, MN, 2001, 2nd Edition.
  6. Nandedkar SD, Barkhaus PE: Quantitative Analysis: Objective & Interactive Assessment in EMG, in Bertorini (ed) Evaluation and Diagnostic Tests in Neuromuscular Disorders. Boston, Butterworth-Heinemann, 2002.
  7. Barkhaus PE: The Electronic Myoanatomic Atlas for Clinical Electromyography. Hopewell Junction, NY, CASA Engineering, 2005, 2nd ed. (Book on multi-media DVD).
  8. Collins MI, Collins MP, Barkhaus PE: Inclusion Body Myositis. In Quan D, Lorenzo NY, Lutsep HL (senior eds): eMedicine Journal (Neurology) [serial online]. 2005. Available at http://www.emedicine.com/neuro/topic422.htm.
  9. Nandedkar SD, Barkhaus PE: Quantitative Analysis: Objective and Interactive Assessment in EMG, in Bertorini T (ed): Evaluation and Tests in Neuromuscular Disorders. Boston, Butterworth Heinnemann, 2002.
  10. Nandedkar SD, Nandedkar, D, Stalberg EV, Barkhaus PE: Motor Unit Number Indexing (MUNIX): A pilot study. In Bromberg M: Motor Unit Number Estimation (MUNE): Supplements to Clinical Neurophysiology, Volume 55. New York, Elsevier, 2003, p 133-140.
  11. Barboi AC, Barkhaus PE: Electrodiagnostic testing in neuromuscular disorders.  Neurol Clinics, 2004; 22(3): 619-640.
  12. Barkhaus PE: Motor Nerve Conductions, Late Responses, and Reflexes. Hopewell Junction, NY, CASA Engineering, 2007, (Book on multi-media DVD).
  13. Lin HC, Barkhaus PE: Cranial Nerve XII: The Hypoglossal Nerve.  Seminars in Neurology 2009; 29; 45-52.
  14. Barkhaus PE:  Basic Myoanatomy in Electromyography with Needle Electrode Placement, in Amato AA, David W: Comprehensive Review of Electrodiagnostic medicine and Neuromuscular Disorders (Multi Media Presentation).  Oakstone Publishing/CMEinfo, 2012.
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