Neurology

Piero G. Antuono, MD

Professor of Neurology, Pharmacology, and Toxicology
Director of the Dementia Research Center

Specialty: Adult Neurology

Sub-Specialty:

• Neuropharmacology of Aging
• Alzheimer's Disease
• Dementia

Education:

Training:

Societies: 
 

Awards/Honors: 
 

Brief Clinical/Research Interest Statement:

Aging of the Brain and Dementia

Original Publications

1. ANTUONO, P.G., Tikofsky, R., Hellman, R., Saxena, V.:  SPECT in the assessment of dementia; Mind (4) 1: 6-8, 1990.
2. Saxena, V.K., ANTUONO, P.G., Tikofsky, R.S., Hellman, R.S.:  SPECT brain imaging:  applications in cerebrovascular disease; Mind (4) 1: 9-11, 1990.
3. Tikofsky, R.S., Saxena, V.K., ANTUONO, P.G., Hellman, R.S.:  Understanding Single Photon Emission Computed Tomography SPECT) brain imaging; Mind (4) 1: 3-5, 1990.
4. Ho K-C, Gwozdz J., Hause L. and ANTUONO, P.G. Correlation of Neuronal Cell Body Size in Motor Cortex and Hippocampus with Body Weight, Body Height and Axonal Length. Intern. J. of Neuroscie.  vol. 65, pp. 147-153 1992.
5. Beyer J., Moser S., ANTUONO, P.G.: Alzheimer Disease and Driving: The role of the Health Care Professional and Caregiver. Nicolini M. Ed. Pergamon Press. In Advances in the Biosciences, Pergamon Press, vol. 87, p. 7-8, 1993.
6. ANTUONO, P.G., Ravanelli-Meyer J. Nicholson K, et al..: Changes of Hexokinase activity with age: Relevance to Alzheimer Disease. Nicolini M. Ed. Pergamon Press. In Advances in the Biosciences, vol. 87, p. 3-4, 1993.
7. Pomara N., Deptula D., ANTUONO, P.G., Singh R., Ravanelli-Meyer J., Cooper T, Leviste F.:Leukocyte hexokinase activity in Alzheimer's disease. Pergamon Press. In Advances in the Biosciences, vol. 87, p. 201-203, 1993.
8. ANTUONO, P.G., Ravanelli-Meyer, J., Nicholson, K., Bloom, A. Leukocyte Hexokinase Activity in Aging and Alzheimer's Disease.  Dementia.  vol. 6, p. 200-204, 1995.
9. ANTUONO, P.G.  Effectiveness and Safety of Velnacrine for the Treatment of Alzheimer's Disease.  Archives of Internal Medicine.  vol 155, p. 1766-72, Sep. 11, 1995.
10. ANTUONO, P.G., Beyer, J. A Reason to Hope:  Linking Dementia Research, Care and Services in the 21st Century.  Wisconsin Medical Journal. vol. 94, p. 546-47, October, 1995.
11. Huff, F.J., ANTUONO, P.G., Delagandara, J.E., et al. A Treatment and Withdrawal Trial of Besipirdine in Alzheimer Disease.  Alzheimer Disease and Associated Disorders  vol. 10, no. 2, p. 93-102, 1996.
12. Huff, F.J., Alter, M., ANTUONO, P.G., et al. Preliminary Evaluation of Besipirdine for the Treatment of Alzheimer's Disease.   The Neurobiology of Alzheimer's Disease/Annals of the New York Academy of Sciences  vol. 777, p. 410-14, January 17 1996.
13. ANTUONO, P.G., Doody, R., Gilman, S., Huff, J., Scheltens, P., Ueda, K., Khachaturian, Z.:  Diagnostic Criteria for Dementia in Clinical Trials; Position Paper from the International Working Group on Harmonization of Dementia Drug Guidelines.   Alzheimer Disease and Associated Disorders  vol. 11, suppl. 3, pp. 22-25, 1997.
14. Wong-Riley, M., ANTUONO, P.G., Ho, K-C., Egan, R., Hevner, R., Liebl, W., Hunag, Z., Rachel, R., Jones, J.:  Cytochrome Oxidase in Alzheimer's Disease:  Biochemical, Histochemical, and  Immunohistochemical Analyses of the Visual and other Systems.   Vision Res., vol. 37, no. 24, p. 3593-3608, 1997.
15. ANTUONO, P.G., Jones, J, Li, SJ, Wang, Y.  Decreased Glutamate + Glutamine in Alzheimer's Disease Detected in vivo with H-1 MR Spectroscopy at 0.5 T. Neurology (Under second review.)
16. Broeren, K.C., Gwozdz, B.S., Morris, R.Ho K-C and, ANTUONO, P.G.  Comparison of neuron density, cross sectional area and total neurons per area of various regions in the hippocampus in Alzheimer's disease versus normal aging (Submitted)
17. Williams, K., Rosen, A., Alexander, M., Hammeke, T., ANTUONO, P.G., Maas, E., DeYoe, A.:  The Perceptual Consequences of Cortical Retinotopy:  Functional Field Mapping in Human Subjects. Neuroimage (229-39) 1998, Vol 8.
18. ANTUONO, P.G., Beyer, J.  The Burden of Dementia, A Medical and Research Perspective.  Theoretical Medicine 20:3-13, 1999.
19. ANTUONO, P.G., Jones, J, Beyer, J.  Alternative Medicine in the Elderly: Use and Abuse.  Elder's Advisor Vol 2 (3): 75-81, 2001.
20. Li, SJ, Jones J., Gaohong Wu and ANTUONO, P.G.  Evaluation of fMRI Index as Marker for Alzheimer's Disease.  Radiology.  In Press .
21. Williams, K., Rosen, A., Alexander, M., Hammeke, T., ANTUONO, P.G., Maas, E., DeYoe, A.: The Perceptual Consequences of Cortical Retinotopy:  Functional Field Mapping in Human Subjects. In Revision.
22. ANTUONO, P.G., Corder, E.H., Franczak, M., Snowdon, D.  Frontal Lobe Function and Rate of Cognitive Decline in the Elderly.  Findings from the Nun Study.  Neurology.  Submitted.
23. ANTUONO, P.G., Jones, J.  Memory Complaints in Older Adults: Correlates with Memory Loss and Depression.  J of Alzheimer's Disease and Related Disorders. Submitted.
24. Seripa, D, Dal Forno, G, Dobrina A, Matera, M, Gravina, C, ANTUONO, P.G., Davis, D, Wekstein, D, Fazio, V.  Association of the interleukin-1 receptor antagonist intron-2 polymorphism with Alzheimer's disease.  Submitted to Nature Genetics
25. Seripa, D, Maraglione M.,Dal Forno, G, Colaizzo D.,Daniele A.,Masullo C., Gravina C, Wekstein, D, ANTUONO, P.G., Davis, D, Fazio, V. Lack of association among angiotensin-converting enzyme (ACE) and Methylentetrahydrofolate reductase (MTHFR) gene polymorphism, and Alzheimer disease. Submitted

Books, Chapters and Reviews

1. Huff, F.J., ANTUONO, P.G., Murphy, M., et al.:  Potential Clinical Use of an Adrenergic-Cholinergic Agent (HP128) and the Treatment of Alzheimer's Disease.  In:  Aging and Alzheimer's Disease  (Growdon, J.H., Corkin, S., Ritter-Walker, E., eds)  New York Academy of Sciences, New York, NY.  263-267, 1991.
2. ANTUONO, P.G:, Korperstellung, Magnus R.:  Rosanoff and Franklicy Book Programs. pp. 801.  Book Review In:  J. Hist. of Medicine.  43:50-501, 1988.
3. ANTUONO, P.G.  Guns and Dementia  In  "Bridges", Dementia Care Network, Alzheimer's Association of S.E. Wisconsin, vol. 3, no. 4, Fall 1997.
4. ANTUONO, P.G.  In Memoriam, Luigi Amaducci, MD (1932-1998). Neurology 50:1513,1998.
5. Krouwer H, Barkhaus P, ANTUONO, P.G.  The Reflexes of Hoffmann, Trömner and Mayer. In Koehler, PJ, Bruyn GW, Pearce JMS (eds) Neurological Eponyns. Oxford Press, New York, 2000, 127-135.
6. ANTUONO, P.G.  Le Risposte Alla Malattia Di Alzheimer.  I Farmaci E La Riabilitazione Treviso. In Press.
7. Krouwer H, Barkhaus P, ANTUONO, P.G.  The Reflexes of Hoffmann, Trömner and Mayer. In: Neurological Eponyms (Koehler, P.J., Bruyn, G.W., Pearce J.M.S.) New York, Oxford, 127-135, 2000.
8. ANTUONO, P.G., Li, S.J., et al.  Functional MRI in Alzheimer's disease. In: Dementia: A Multidisciplinary Approach.  (Mangone C., Allegri R, Arizaga R, Ollari J. Eds). Editorial Medica Panamericana. In Press.
9. ANTUONO, P.G., Franczak M.  Lo Studio Sulle Suore Scolastiche Di Nostra Signora.   Fattori di Rischio per L'Alzheimer'.  L'Alzheimer 2000. Firenze Anno III. 12-14.
10. ANTUONO, P.G.  Prevenzione Delle Malattie Cerebrovasculari Riduce L'Alzheimer. Alzheimer 2000 Firenze. Anno III, 15-16.

Grants & Funding

Title: Safety and efficacy of MK-0966 for the prevention of Alzheimer's Disease.
Source:
Role: Principal Investigator (5% effort)
Dates: 1998-2001

Title: Gingko Biloba special extract Egb761 in dementia of the Alzheimer's type.  A double-blind multicenter study.
Source: W.Schabe GmbH and Company/Worldwide Clinical Trials.
Role: Principal Investigator (5% effort)
Dates: 1999-2001

Title: Independent life in the elderly (The Nun Study).
Source: National Institute of Health.
Role: Co-investigator (5% effort), Principal Investigator, Dr. Snowdon
Dates: 1996-2000

Title: Independent life in the elderly (The Nun Study).
Source: National Institute of Health.
Role: Subcontracted (10% effort),  Principal Investigator, Dr. Snowdon.
Dates: 1999-2001

Title: Functional MRI in Alzheimer's Disease.
Source: Cassie M. Bach Memorial Research Fund.
Role: Principal Investigator (5% effort)
Dates: 1998-2003

Title: Protocol 126-01 "The Safety and Efficacy of MK-0966 25 mg in Delaying the Progression of Symptoms of Alzheimer's Disease in Patients With Probable Alzheimer's Disease"
Source: IRC#00-151  HRRC#258-00.
Role:
Dates: 2000-2001

Title: MK-0966 for the Treatment of Mild Cognitive Impairment and Prevention of Conversion to Alzheimer's Disease
Source: HRRC#104-98  IRC#98-59.
Role: 5% effort.
Dates: 1999-2002

Title: Establishment of Community Based Multispecialty Clinics for Diagnosis and Management of Dementia.
Source: Helen Bader Foundation
Role: Principal Investigator (5% effort)
Dates: 2000-2001

Title: Neurological Exams in the Nun Study.
Source: Helen Bader Foundation.
Role: Principal Investigator. (pending)
Dates: 2000-2001

Title: (State Grant) Administration on Aging. Alzheimer's Disease Demonstrative Grant to States (90AZ2359)
Source:  Wisconsin State Department of Health & Family Services
Role:  Co-investigator P1
Dates:  2000-2003

Title: MR Spectroscopy in Alzheimer's Disease.  Pharmacological effects in mild cognitive impairment.
Source:
Role: Principal Investigator (5% effort)
Dates: 2000-2003

Title: Resting state in functional MRI.
Source: The Alzheimer's Association.
Role: Co-investigator (5% effort)
Dates: 2000-2003

Title: Alzheimer's Disease by functional MRI.
Source: The National Institute of Health.
Role: Co-investigator (25% effort)
Dates: 2000-2005

Title: Independent life in the elderly (The Nun Study).
Source: National Institute of Health.
Role: Subcontract: Neurological Examinations (10% effort),  PI, Dr. Snowdon.
Dates: 1999-2001

Title: Glen and Gertrude Humphrey Foundation Endowment for Research in Alzheimer's Disease
Source: Glen and Gertrude Humphrey Foundation
Role: Endowment To Dementia Center
Dates: 2001

Title: Management of Alzheimer's Disease
Source: Industry
Role: Organizer, Planner, Moderator, Presenter
Dates: February 10, 2001

Title: Epidemiology of Dementias In Africa
Nairobi, Kenya
Source: Industry
Role: Organizer
Dates: April 23 2001

Title: Future Trends in Dementia: Alzheimer's Disease International
 Christchurch, New Zealand
Source: Industry
Role: Organizer
Dates: October 27, 2001

Title: Creation of a Dataportal of the Nun Study in Wisconsin
  (Pending for 1/1/01)
Source: Helen Bader Foundation.
Role: Principal Investigator (5% effort)
Dates: 2000-2001

Title: The Neurological Exam in the Nun Study (withdrawn)
Source: Helen Bader Foundation.
Role: Principal Investigator (5% effort)
Dates: 2000-2001

Title: An fMRI Index as a Risk Marker for Alzheimer's Disease (Pending)
Source: The National Institute of Health.
Role: Co-investigator (15% effort)
Dates: 2000-2005

Title: Mechanisms of an fMRI Index for Alzheimer's Disease (Pending)
Source: The National Institute of Health
Role: Co-Investigator (10% effort)
Dates: 2001-2003

Title: Drug Effects on an fMRI Marker in MCI (Pending)
Source: Janssen Pharmaceuticals
Role: Principle Investigator (5% effort)
Dates: 2001-2002

Title: Exelon in Mixed Dementia (Pending)
Source: Novartis Pharmaceutical
Role: Principle Investigator (5% effort)