Matthew D. Budde, PhD
Department of Neurosurgery
Zablocki VA Medical Center
Neuroscience Research Labs- Research 151
5000 W. National Avenue
Milwaukee, WI 53295
Phone: (414) 955-2394
Research Area: Development and application of magnetic resonance imaging techniques to diagnose and monitor brain and spinal cord injury.
Apply advanced MRI techniques, including diffusion tensor imaging (DTI), to detect and monitor injury to the central nervous system noninvasively
Define the specific biological features that give rise to the MRI findings using animal models of neurological injury
Determine the prognostic capabilities of MRI in acute brain and spinal cord trauma
The primary focus of my research is to use magnetic resonance imaging (MRI) to evaluate injury and disease in the brain and spinal cord. In particular, diffusion tensor imaging (DTI) is an advanced MRI technique that is unique in its ability to detect and visualize white matter pathways noninvasively. It is exquisitely sensitive to injury and has been widely applied to many types of brain and spinal cord injury or disease. However, the specific biological features that give rise to DTI findings are poorly understood and could limit the application of DTI as a clinical tool.
My research aims are to (1) determine the biophysical mechanisms that underlie DTI abnormalities following CNS injury, and (2) develop MRI techniques that are more sensitive to injury following brain and spinal cord trauma. I use a variety of techniques to address these aims including: in vivo MRI in animal models, excised tissue preparations, and histological preparations, as well as computational models and quantitative image analysis. Ultimately, it is believed that improvements in MRI technology combined with a better understanding of the underlying biological substrates will facilitate the development, evaluation, and application of therapeutic interventions. These advances are hoped to improve long-term outcome after acute neurological injury.
Education and Research
University of Wisconsin-Madison, BS, Psychology & Communication Arts, 2001
Washington University, PhD, Neuroscience, 2008
Dissertation: Detecting Axonal Damage in a Mouse Model of Multiple Sclerosis with Diffusion Tensor Imaging
National Institutes of Health-Radiology and Imaging Sciences, Postdoctoral Fellowship, 2008-2011