Pathology

Horatiu Olteanu, MD, PhD

Assistant Professor of Pathology, Medical College of Wisconsin
Director of Flow Cytometry, Dynacare Laboratories

Dr. Olteanu's primary clinical activity is in the Hematopathology service at Froedtert Hospital, with additional appointments at Children’s Hospital of Wisconsin and Community Memorial Hospital.  He is also involved in medical student, pathology resident and Hematopathology fellow teaching.

Research Interests

• Clinical and pathologic characterization of hematolymphoid malignancies

Professional Background

• Assistant Professor of Pathology, MCW, Milwaukee, WI (2008 - present)

Educational Background

• Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania – MD
• University of Nebraska, Lincoln, NE – PhD (Biochemistry)
• University of Texas Southwestern Medical Center, Dallas, TX – Anatomic and Clinical Pathology residency
• Medical College of Wisconsin, Milwaukee, WI – Hematopathology fellowship

Board Certifications

• Anatomic and Clinical Pathology
• Hematopathology

Selected Publications

• Olteanu, H., Downes, K.A., Patel, J., Praprotnik, D., Sarode, R.: Warfarin does not interfere with lupus anticoagulant detection by dilute Russel’s viper venom time. Clin Lab 55 (3-4): 138-142, 2009.
• Olteanu, H., Wang, H., Chen, W., McKenna, R.W., Karandikar, N.J.: Immunophenotypic studies of monoclonal gammopathy of undetermined significance. BMC Clin Pathol 8 (13): 1-9, 2008.
• Olteanu, H., Karandikar, N.J., Eshoa, C., Kroft, S.H.: Laboratory Findings in CD4(+) Large Granular Lymphocytoses. Int J Lab Hematol, 2008. (accepted for publication).
• Dyszkiewicz-Korpanty, A., Olteanu, H., Frenkel, EP., SarodeR.: Clopidogrel Anti-Platelet Effect: An Evaluation by Optical Aggregometry, Impedance Aggregometry, and the Platelet Function Analyzer (PFA-100™). Platelets 9:1-6, 2007.
• Olteanu, H., Karandikar, N.J., McKenna, R.W., Xu, Y.: Differential usefulness of various markers in the flow cytometric detection of paroxysmal nocturnal hemoglobinuria in blood and marrow. Am J Clin Pathol 126 (5): 781-788, 2006.
• Olteanu, H., Xu, Y.: The use of flow cytometry in diagnosis of paroxysmal nocturnal hemoglobinuria. Lab Med 37 (8): 2-6, 2006.
• Olteanu, H., Gerber, D., Partridge, K., Sarode, R.: Acute hemolytic transfusion reaction secondary to anti-Fy3. Immunohematol 21: 48-52 2005.
• Zhang, W., Braun, A., Bauman, Z., Olteanu, H., Madzelan, P., Banerjee, R.: Expression profiling of homocysteine junction enzymes in the NCI60 panel of human cancer cell lines. Cancer Res 65 (4): 1554-1560, 2005.
• Leal, NA., Olteanu, H., Banerjee, R., Bobik, TA.: Purification and initial characterization of the human ATP:cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase. J Biol Chem 279 (46): 47536-47542, 2004.
• Waly, M., Olteanu, H., Banerjee, R., Choi, SW., Mason, JB., Parker, BS., Sukumar, S., Shim, S., Sharma, A., Benzecry, JM., Power-Charnitsky, VA., Deth, RC.: Activation of methionine synthase by insulin-like growth factor-1 and dopamine: A target for neurodevelopmental toxins and thimerosal. Mol Psych 9 (4): 358-370, 2004.
• Olteanu, H., Wolthers, KR., Munro, AW., Scrutton, NS., Banerjee, R.: Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase. Biochemistry 43 (7): 1988-1997, 2004.
• Olteanu, H., Banerjee, R.: Redundancy in the pathway for redox regulation of mammalian methionine synthase: Reductive activation by the dual flavoprotein novel reductase 1. J Biol Chem 278 (40): 38310-38314, 2003.
• Olteanu, H., Munson, T., Banerjee, R.: Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase.  Biochemistry 41 (45): 13378-13385, 2002.
• Olteanu, H., Banerjee, R.: Human methionine synthase reductase, a soluble P450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation. J Biol Chem. 276 (38): 35558-35563, 2001.