Pathology

Jason A. Jarzembowski, MD, PhD

Assistant Professor of Pathology, Medical College of Wisconsin
Program Director, Perinatal Pathology, Children's Hospital of Wisconsin
Associate Director, Pediatric BioBank, Children’s Hospital of Wisconsin
Medical Advisor, Infant Death Center of Wisconsin

Dr. Jarzembowski serves as Assistant Professor at the Medical College of Wisconsin and Program Director of Perinatal Pathology at Children’s Hospital of Wisconsin.  His clinical responsibilities include pediatric surgical pathology, placental pathology, and autopsy pathology.  He supervises a research program studying molecular abnormalities of the pediatric tumor neuroblastoma.  He serves on the Editorial Board of the journal Archives of Pathology and Laboratory Medicine and is a fellow of both the College of American Pathologists and the American Society for Clinical Pathology.  He is also an active member of the United States and Canadian Academy of Pathology, the Society for Pediatric Pathology, and Sigma Xi.

Research Interests

• Neuroblastoma
• Molecular biology of pediatric solid tumors
• Placental pathology
• Fetal and infant health

Professional Background

• Armand J. Quick Award for Excellence in Biochemistry, Medical College of Wisconsin (2002)
• Young Investigator Research Award, Society for Pediatric Pathology (2006)
• Young Investigator Mentee, Children's Oncology Group (2008)

Educational Background

• PhD, University of Wisconsin-Madison (1998)
• MD, Medical College of Wisconsin (2002)
• Residency, University of Michigan (2006)
• Fellowship, Washington University in St. Louis (2007)

Board Certifications

• Anatomic and Clinical Pathology
• Pediatric Pathology

Selected Publications

• Akers AY, Jarzembowski JA, Johnson C, Lieberman RW, Dalton VK. Examining the relationship between positive mid-gestational fetal fibronectin assays and acute histologic placental inflammation at delivery. J Perinatal Med 2007:35;36-42.
• Martin DT, Gendron RL, Jarzembowski JA, Perry A, Collins MH, Pushpanathan C, Miskiewicz E, Castle VP, Paradis H. Tubedown expression correlates with the differentiation status and aggressiveness of neuroblastic tumors. Clin Cancer Res 2007;13(5):1480-1487.
• Jarzembowski JA. Anaplastic large cell lymphoma: looks can be deceiving. Pediatr Dev Pathol 2007;10:169-171.
• Jarzembowski JA, Lloyd RV, McKeever PA. Type IV collagen immunostaining is a simple, reliable diagnostic tool for distinguishing between adenomatous and normal pituitary glands. Arch Pathol Lab Med 2007;131:931-935.
• Subramanian C, Jarzembowski JA, Opipari Jr AW, Castle VP, Kwok RPS. CREB-binding protein is a mediator of neuroblastoma cell death induced by the histone deacetylase inhibitor trichostatin A. Neoplasia 2007;9(6):495-503.
• Hill DA, Jarzembowski JA, Priest JR, Williams, G, Schoettler P, Dehner LP. Type I pleuropulmonary blastoma (PPB): pathology and biology study of 51 cases from the international pleuropulmonary blastoma registry. Am J Surg Pathol 2008;32(2):282-295.
• Chamdin A, Jarzembowski J, Subramanian C, Kuick R, Shin-Jung Lee J, Kwok R, Castle V, Opipari Jr. A. W. Bcl-6 is expressed in neuroblastoma: tumor cell type specific expression predicts outcome. Translational Oncol 2009;2(3):128-37.
• Garcia J, Faça V, Jarzembowski J, Zhang Q, Park J, and Hanash SM. Comprehensive profiling of the cell surface proteome of SY5Y neuroblastoma cells yields a subset of proteins associated with tumor differentiation. J Proteome Res 2009;8(8):3791–3796.
• Hill DA, Ivanovich J, Priest JR, Gurnett CA, Dehner LP, Desruisseau D, Jarzembowski JA, Wikenheiser-Brokamp KA, Suarez BK, Whelan AJ, Williams G, Bracamontes D, Messenger Y, Goodfellow PJ. DICER1 mutations in familial pleuropulmonary blastoma. Science 2009;325(5943):965.