Pathology

Alexander Craig Mackinnon, Jr., MD, PhD

Assistant Professor, Medical College of Wisconsin
Director, Clinical and Translational Research Core Lab

Dr. Mackinnon is responsible for the research activities that are conducted in the research core lab of the pathology department at the Medical College of Wisconsin.  He is also involved in the molecular diagnostics clinical service.

Research Interests

• Molecular diagnostics of solid tumor and hematological malignancies
• Cardiovascular pathology
• Cell adhesion/Integrin signaling

Professional Background

• Resident, Anatomical Pathology, University of Chicago Medical Center
• Postdoctoral Fellow, Cardiovascular Pathology, University of Chicago Medical Center
• Clinical Fellow, Molecular Genetic Pathology, University of Chicago Medical Center
• Clinical Fellow, Molecular Genetic Pathology, NorthShore University HealthSystems

Educational Background

• BA, University of Colorado, Boulder, CO
• MS, Northwestern University, Evanston, IL
• MD, University of Illinois, Urbana-Champaign, IL
• PhD, University of Illinois, Urbana-Champaign, IL

Board Certifications

• Anatomic Pathology
• Molecular Genetic Pathology

Selected Publications

• Claude G. Lerner, Anne Y. Chiang Saiki, A. Craig Mackinnon, and Xiaoling Xuei. 1996. High throughput screen for inhibitors of bacterial DNA topoisomerase I using the scintillation proximity assay. Journal of Biomolecular Screening 1:135-143.
• Steven D. Pratt, Xiaoling Xuei, Alexander C. Mackinnon, Angela M. Nilius, Dena M. Hensey-Rudloff, Ping Zhong, and Leonard Katz. 1997. Development of a coupled VanA/VanX assay: Screening for inhibitors of glycopeptide resistance. Journal of Biomolecular Screening 2:241-247.
• A. Craig Mackinnon, H. Qadota, K. Norman, D.G. Moerman, and Benjamin D. Williams. 2002. C. elegans PAT-4/ILK Functions as an Adaptor Protein within Integrin Adhesion Complexes. Current Biology 12:787-797.
• Jagadeeswaran R, Surawska H, Krishnaswamy S, Janamanchi V, Mackinnon AC, Seiwert TY, Loganathan S, Kanteti R, Reichman T, Nallasura V, Schwartz S, Faoro L, Wang YC, Girard L, Tretiakova MS, Ahmed S, Zumba O, Soulii L, Bindokas VP, Szeto LL, Gordon GJ, Bueno R, Sugarbaker D, Lingen MW, Sattler M, Krausz T, Vigneswaran W, Natarajan V, Minna J, Vokes EE, Ferguson MK, Husain AN, Salgia R.. 2007. Paxillin is a Target for Somatic Mutations in Lung Cancer: Implications for Cell Growth and Invasion. Cancer Research. Jan 1, 2008; 68 (1).
• Ma PC, Tretiakova MS, Mackinnon AC, Ramnath N, Johnson C, Dietrich S, Seiwert T, Christensen JG, Jagadeeswaran R, Krausz T, Vokes EE, Husain AN, Salgia R. 2008. Expression and mutational analysis of MET in human solid cancers. Genes Chromosomes Cancer. 2008 Dec;47(12):1025-37.
• Ilyssa O. Gordon, S. Sitterding, A. Craig Mackinnon, and Aliya N. Husain. 2009. Update in Neoplastic Lung Diseases and Mesothelioma. Archives of Pathology and Laboratory Medicine. Archives in Surgical Pathology, July 2009.
• Ilyssa O. Gordon, N. Cipriani, Q. Arif, A. Craig Mackinnon, and Aliya N. Husain. 2009. Update in Non-neoplastic Lung Diseases. Archives of Pathology and Laboratory Medicine. Archives in Surgical Pathology, July 2009.
• *Benjamin C. Yan, MD, PhD, *A. Craig Mackinnon, MD, PhD, Hikmat A. Al-Ahmadie, MD. 2009. Recent Developments in the Pathology of Renal Tumors: Morphology and Molecular Characteristics of Select Entities. Archives of Pathology and Laboratory Medicine. Archives in Surgical Pathology, July 2009.
• *A. Craig Mackinnon, MD, PhD, *Benjamin C. Yan, MD, PhD, Loren J. Joseph, MD, Hikmat A. Al-Ahmadie, MD. 2009. Updates on the Molecular Biology Underlying the Clinical Heterogeneity of Prostate Cancer. Archives of Pathology and Laboratory Medicine. Archives in Surgical Pathology, July 2009.
• Rish K. Pai, A. Craig Mackinnon, L. Joseph, A. Noffsinger, and J. Hart. 2010. Identification of histologically unique conventional adenomas that arise predominately in patients with sessile serrated adenomas. American Journal of Surgical Pathology. American Journal of Surgical Pathology. Mar; 34(3):355-63.
• Zhiguang Gao, G. Kim, A. Craig Mackinnon, A. E. Flagg, B. Bassett1, J. U. Earley, and Eric C. Svensson. 2010. Ets-1 is required for Proper Migration and Differentiation of the Cardiac Neural Crest. Development 137, 1543-1551.