Pathology

Tara Sander, PhD

Associate Professor of Pathology, Pediatric Pathology
Medical College of Wisconsin
Scientific Director of Molecular Diagnostics
Children's Hospital of Wisconsin

Dr. Sander is involved in the clinical and research aspects of molecular pathology and laboratory medicine. 
As Scientific Director, Dr. Sander directs the development, operation, and expansion of the Molecular
Diagnostics Laboratory at Children's Hospital of Wisconsin.  This clinical laboratory provides state-of-the-art molecular testing for the diagnosis and treatment of children with non-infectious disease.

The clinical laboratory offers Pharmacogenetics testing for children evaluated in the Neurology Clinic as a way to better guide anticonvulsant medication therapy.  In addition, the lab offers testing for Cystic Fibrosis and 22q11.2 deletion syndrome (i.e., DiGeorge Syndrome), which are used as aids in newborn
screening and in confirmatory diagnostic testing.  Goals of the laboratory include developing additional genetic tests for diseases and conditions including mitochondrial disorders, hearing loss, and vascular anomalies using cutting edge platforms such as next generation sequencing and droplet digital PCR.  Dr. Sander also participates in translational research activities, bridging the areas of basic biology and clinical molecular diagnostics.  Her aim is to work with investigators to identify genetic variations that cause congenital disorders and translate these discoveries to the clinic for the development of novel diagnostic tests for the pediatric population.

Research Interests

• Molecular basis of congenital and acquired vascular diseases including vascular anomalies, valvular heart disease, acute lung injury, and cancer
• Endothelial cell function and vascular response to injury
• Transcriptional regulation of the SCAN domain family of zinc finger proteins

Professional Background

• Associate Professor, Department of Pathology and Surgery (Pediatric), Medical College of Wisconsin
  (2010 - present)
• Assistant Professor, Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin 
  (2003 - 2008)
• Investigator, Children’s Research Institute (2007 - present)
• Assistant Professor, Department of Pathology, Division of Pediatric Pathology, Medical College of Wisconsin (2008 - 2010)
• Scientific Director, Molecular Diagnostics Laboratory, Pathology & Laboratory Medicine, Children’s Hospital of Wisconsin (2008 - present)
• Director, DNA Extraction Service for Clinical Research, Children’s Hospital of Wisconsin (2009 - present)
• Chair, Committee for Career Development, Women and Minorities, American Society for Investigative Pathology (2009 - 2012)
• Councilor, American Society for Investigative Pathology (2009 - 2012)
• Chair, Women’s Faculty Council, Medical College of Wisconsin (2008 - 2009)

Educational Background

• BS, Biochemistry, Beloit College, 1994
• PhD, Biochemistry, Medical College of Wisconsin, 2000
• Research Fellow, Harvard Medical School, Children’s Hospital Boston, 2000-2003

Selected Publications

• Wong, SHY, Happy, C., Blinka, D., Gock, S., Jentzen, J.M., Donald Hon, J.M., Coleman, H., Jortani, S.A., Lucire, Y., Morris-Kukoski, C.L., Neuman, M.G., Orsulak, P.J., SANDER, T., Wagner, M.A., Wynn, J.R., Wu, AHB, and Yeo, KTJ.  From personalized medicine to personalized justice:  The promises of translational pharmacogenomics in the justice system.  Pharmacogenomics 11(6):731-737, 2010.
• Pratt, V.M., Zehnbauer, B., Wilson, J.A., Baak, R., Babic, N., Bettinotti, M., Buller, A., Butz, K., Campbell, M., Civalier, C., El-Badry, A., Farkas, D.H., Lyon, E., Mandal, S., McKinney, J., Muralidharan, K., Noll, L., SANDER, T., Shabbeer, J., Smith, C., Telatar, M., Toji, L., Vairavan, A., Vance, C., Weck, K., Wu, A., Yeo, K-T.J., Zeller, M., and Kalman, L.  Characterization of 107 genomic DNA reference materials for CYP2D6, CYP2C19, CYP2C9, VKORC1 and UGT1A1: A GeT-RM and Association for Molecular Pathology collaborative project.  J Mol Diagn. 12(6):835-846, 2010
• Peterson, J.F., Doern, C.D., Kallstrom, G., Riebe, K.M., Sander, T., Dunne, Jr., W.M., and Ledeboer, N.A.  Evaluation of spectra VRE, a new chromogenic agar medium designed to screen for vancomycin-resistant Enterococcus faecalis and Enterococcus faecium.  J. Clin. Microbiol. 48(12):4627-9, 2010
• Johnson, E.N., Lee, Y.M., SANDER, T.L., Kaushal, S., Rabkin, E., Schoen, F.J. and Bischoff, J. An NFATc1-dependent pathway for VEGF-mediated proliferation in human pulmonary valve endothelial cells. J Biol Chem. 278(3):1686-92, 2003.
• SANDER, T.L., Stringer, K.F., Maki, J.L., Szauter, P., Stone, J.R. and Collins, T. The SCAN domain defines a large family of zinc finger transcription factors. Gene 310:29-38, 2003.
• Klinkner, D.B., Densmore, J.C., Kaul, S., Noll, L., Lim, H.J., Weihrauch, D., Pritchard, K.A., Oldham, K.T. and SANDER, T.L. Endothelium-derived microparticles (EMPs) inhibit human cardiac valve endothelial cell function. Shock 25(6):575-80, 2006.
• SANDER, T.L., Noll, L., Klinkner, D.B., Weihrauch, D., He, B.J., Kaul, S., Zangwill, S.D., Tweddell, J.S., Pritchard, K.A. and Oldham, K.T. Rosiglitazone antagonizes VEGF signaling and NFATc1 activation in cardiac valve endothelium. Endothelium 13(3):181-90, 2006.
• Peterson, F.C., Hayes, P.L., Waltner, J.K., Heisner, A.K., Jensen, D.R., SANDER, T.L. and Volkman, B.F. Structure of the SCAN domain from the tumor suppressor protein MZF1. J Mol Biol. 363:137-147, 2006.
• Klinkner, D.B., Lim, H.J., Strawn, E.Y., Oldham, K.T. and SANDER, T.L. An in vivo murine model of rosiglitazone use in pregnancy. Fertil Steril 86 Suppl 4:1074-1079, 2006.
• SANDER, T.L., Ou, J-S., Densmore, J.C., Kaul, S., Matus, I., Twigger, S., Halligan, B., Greene, A.S., Pritchard, Jr., K.A., and Oldham, K.T. Protein composition of PAI-1-derived endothelial microparticles. Shock 29(4):504-511, 2008.
• Peterson, D.B., SANDER, T., Kaul, S., Wakim, B.T., Halligan, B., Twigger, S., Pritchard, Jr., K.A., Oldham, K.T., and Ou, J-S. Comparative proteomic analysis of PAI-1 and TNF-alpha derived endothelial microparticles. Proteomics 8(12):2430-2446, 2008.
• Noll, L., Peterson, F., Hayes, P., Volkman, B., and SANDER, T. Heterodimer formation of the myeloid zinc finger 1 SCAN domain and association with promyelocytic leukemia nuclear bodies. Leukemia Research 32(10):1582-92, 2008.