Yian Wang, PhD
BS/MD - Medicine, Beijing University School of Medicine - 1982
PhD - Pathology, Toledo University School of Medicine - 1990
There are several strategies in cancer prevention. The major ones include risk management, chemoprevention, and immunoprevention. The risk management is through reduction of exposure to environmental hazardous factors, such as asbestos, tobacco, and alcohol. In order to reduce the risk of, or delay the development or recurrence of cancer, chemoprevention is the use of drugs, vitamins, or other agents; and, immunoprevention is an approach to use vaccines, antibodies, and immune modulators. My research focus is using human cancer models in pre-clinical setting to study the efficacy of drugs and/or vaccines in cancer prevention.
Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E, Hu M, Lubet RA, You M. Chemopreventive effect of a mixture of Chinese herbs (antitumor B) on chemically induced oral carcinogenesis in A/J mice. Molecular Carcinogenesis 2013;52:49-56. PMID: 22086836
Dragnev K, You M, Wang Y, Lubet R. Lung cancer chemoprevention: difficulties, promise and potential agents? Expert Opin Investig Drugs 2013;22:35-47. PMID: 23167766.
You MS, Rouggly LC, You M, Wang Y. Mouse models of lung squamous cell carcinomas. Review. Cancer Metastasis Rev 2013;32:77-82. PMID: 23229817
Pan J, Zhang Q, Li K, Liu Q, Wang Y, You M. Chemoprevention of Lung Squamous Cell Carcinoma by Ginseng. Cancer Prev Res 2013;6:6 530-9. PMID: 23550152
You MS, Rouggly LC, Hu, M, Yang Z, You M, Wang Y. Chemoprevention of Lung Cancer by Ginseng. In: Inflammation, Oxidative Stress, and Cancer - Dietary Approaches for Cancer Prevention, (Ah-Ng Tony Kong, ed), CRC Press -Taylor & Francis Group, Boca Raton, London, New York, pp. 491-524, 2013.
Wang Y, Rouggly LC, You M, Lubet RA. Animal models of lung cancer characterization and use for chemoprevention research. Prog Mol Biol Transl Sci 2012;105:211-26. PMID: 22137433
Wang Y, James M, Wen W, Lu Y, Szabo E, Lubet RA, You M. Chemopreventive Effects of Pioglitazone on Chemically Induced Lung Carcinogenesis in Mice. Mol Cancer Ther 2010;9:3074-82. PMID: 21045137
Wang Y, Wen W, Yi Y, Lubet RA, You M. Preventive Effects of Bexarotene and Budesonide in a Genetically Engineered Mouse Model of Small Cell Lung Cancer. Cancer Prev Res 2009;2:1059-1064. PMID: 19934342
Wang Y, Zhang Z, Garbow JR, Rowland DJ, Lubet RA, Sit D, Law F, You M. Chemoprevention of Lung Squamous Cell Carcinoma in Mice by a Mixture of Chinese Herbs. Cancer Prev Res 2009;2:634-40. PMID: 19584077
You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, et al. Fine Mapping of Chromosome 6q23-25 Region in Familial Lung Cancer Families Reveals RGS17 as a Likely Candidate Gene. Clin Cancer Res 2009;15:2666-74. PMID: 19351763