Pharmacology and Toxicology

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Yi-Wen Huang, PhD

Assistant Professor
College of Veterinary Medicine at Ohio State (2006)
PhD Veterinary Biosciences
Epigenetics in Cancer
Phone: 414 955-2945
ywhuang@mcw.edu
Dr. Huang's Faculty Collaboration Database

Research Interest

Dr. Huang is an Assistant Professor at the Department of Obstetrics and Gynecology, Medical College of Wisconsin in July, 2012. He received his Ph.D. in the Veterinary Biosciences, College of Veterinary Medicine at Ohio State University in June, 2006. After that, he joined Dr. Tim Huang’s laboratory as a post-doctoral researcher to study on epigenetics, specifically on DNA methylation at Ohio State University.

Dr. Huang’s research interests are investigating the roles of epigenetics in cancer development. He has extensive experience in using methylation microarray technology to identify candidate epigenetic biomarkers for disease detection and recurrence in ovarian and endometrial cancers. He also has experience in studying DNA methylation changes using next-generation sequencing. Applying this technique, Dr. Huang generated more than half billions of sequencing bases from more than 200 primary endometrial and breast specimens, and elucidated specific DNA methylator phenotypes.

His laboratory focuses on identifying epigenetic changes involved in the endometrial tumorigenesis. Currently, a mouse model was applied to understand how obesity might contribute to endometrial cancer development and how chemopreventive agents such as berries might suppress this disease.


Recent Publications

Rao X, Evans J, Chae H, Pilrose J, Kim S, Yan P, Huang RL, Lai HC, Lin H, Liu Y, Miller D, Rhee JK, Huang YW, Gu F, Gray JW, Huang TM, Nephew KP.   CpG island shore methylation regulates caveolin-1 expression in breast cancer.   Oncogene.   2012 Nov 5:.

Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone G.  Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol. 2012 Nov;14(11):1192-202.

Rivas MA, Venturutti L, Huang YW, Schillaci R, Huang TH, Elizalde PV.   Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development.   Breast Cancer Res. 2012;14(3):R77.

Yeh KT, Chen TH, Yang HW, Chou JL, Chen LY, Yeh CM, Chen YH, Lin RI, Su HY, Chen GC, Deatherage DE, Huang YW, Yan PS, Lin HJ, Nephew KP, Huang TH, Lai HC, Chan MW.   Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer.   Epigenetics. 2011 Jun;6(6):727-39.

Ozer HG, Huang YW, Wu J, Parvin JD, Huang TH, Huang K.   Comparing multiple ChIP-sequencing experiments.   J Bioinform Comput Biol. 2011 Apr;9(2):269-82.

Wang QE, Milum K, Han C, Huang YW, Wani G, Thomale J, Wani AA.   Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells.   Mol Cancer. 2011;10:24.

Sun S, Chen Z, Yan PS, Huang YW, Huang TH, Lin S.   Identifying hypermethylated CpG islands using a quantile regression model.   BMC Bioinformatics. 2011;12:54.

Zuo T, Liu TM, Lan X, Weng YI, Shen R, Gu F, Huang YW, Liyanarachchi S, Deatherage DE, Hsu PY, Taslim C, Ramaswamy B, Shapiro CL, Lin HJ, Cheng AS, Jin VX, Huang TH.   Epigenetic silencing mediated through activated PI3K/AKT signaling in breast cancer.   Cancer Res. 2011 Mar 1;71(5):1752-62.

Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, Martin E, Huang TH, Riedl K, Schwartz S, Frankel W, Pearl D, Xu Y, Winston J 3rd, Yang GY, Stoner G.   Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study.   Clin Cancer Res. 2011 Feb 1;17(3):598-610.

Wang G, Wang Y, Shen C, Huang YW, Huang K, Huang TH, Nephew KP, Li L, Liu Y.   RNA polymerase II binding patterns reveal genomic regions involved in microRNA gene regulation.   PLoS One. 2010;5(11):e13798.

Huang YW, Kuo CT, Stoner K, Huang TH, Wang LS.   An overview of epigenetics and chemoprevention.   FEBS Lett. 2011 Jul 7;585(13):2129-36.

 

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