Pharmacology and Toxicology

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J.R. Falck, PhD

Robert A. Walch Distinguished Chair in Chemistry
UT Southwestern Medical Center
Phone: 241-648-3338
Fax: 214-648-8856

Research Interests

Medicinal Chemistry
Natural Products Isolation and Identification
Synthetic Methodology
Total Synthesis

Selected Publications

Tunctan, B., Korkmaz, B., Butaralioglu, C.K., Firat, S.S., Anjaiah, S., Falck, J.R., Roman, R.J., and K.U. Malik: A 20-Hydroxyeicosatetraenoic Acid Agonist, N-[20-Hydroxyeicosa-5(Z),14-(Z)-Dienoyl]Glycine, Opposes the Fall in Blood Pressure and Vascular Reactivity in Endotoxin-Treated Rats. Shock 2008; (30):329-335

Li, D-R., Murugan, A., and J.R. Falck: Enantioselective, Organocatalytic Oxy-Michael Addition to γ/δ-Hydroxy-α,β-enones: Boronate-Amine Complexes as Chiral Hydroxide Synthons.  J. Am. Chem. Soc., 2008; (130):46-48
Illies, C., Gromada, J., Fiume, R., Leibiger, B., Yu, J., Juhl, K., Yang, S-N., Barma, D., Falck, J.R., Saiardi, A., Barker, C.J., and P-O Berggren: Requirement of Inositol Pyrophosphates for Full Exocytotic Capacity in Pancreatic β Cells.  Science 2007; (318):1299-1302
Falck, J.R., He, A., Fukui, H., Tsutsui, H., and A. Radha: Synthesis and Stereochemical Assignment of FR252921, a Promising Immunosuppressant. Angew. Chem. Int. Ed. 2007; (46):4527-4529
Baati, R., Mioskowski, C., Kashinath, D., Kodepelly, S., Lu, B., and J.R. Falck: Stereoselective Synthesis of Methyl (Z)-α-methoxyacrylates via Two-Carbon Homologation of Aldehydes.  Tetrahedron Lett. 2009; (50):402-405
He, A., and J.R. Falck: Synthesis of Enantioenriched α-(Hydroxyalkl)-tri-n-butylstannanes.  Angew. Chem. Int. Ed. 2008; (47):6586-6589
Rasko, D.A., Moriera, C.G., Li, D.R., Readings, N.C., Ritchie, J.M., Waldor, M.K., William, N., Taussig, R., Wei, S., Roth, M., Hughes, D.T., Huntley, J.F., Fina, M.W., Falck, J.R., and V. Sperandio: Targeting QseC Signaling and Virulence for Antibiotic Development. Science 2008; (321):1078-1080
Lu, B., and J.R. Falck: Efficient Iridium-Catalyzed C-H Functionalization/Silylation of Heteroarenes.  Angew. Chem. Int. Ed. 2008; (47):7508-7510
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Page Updated 05/15/2013