Pharmacology and Toxicology

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J.R. Falck, PhD

Professor
Robert A. Walch Distinguished Chair in Chemistry
UT Southwestern Medical Center
Phone: 241-648-3338
Fax: 214-648-8856
j.falck@utsouthwestern.edu


Research Interests

Medicinal Chemistry
Natural Products Isolation and Identification
Organometallics
Synthetic Methodology
Total Synthesis


Selected Publications

Tunctan, B., Korkmaz, B., Butaralioglu, C.K., Firat, S.S., Anjaiah, S., Falck, J.R., Roman, R.J., and K.U. Malik: A 20-Hydroxyeicosatetraenoic Acid Agonist, N-[20-Hydroxyeicosa-5(Z),14-(Z)-Dienoyl]Glycine, Opposes the Fall in Blood Pressure and Vascular Reactivity in Endotoxin-Treated Rats. Shock 2008; (30):329-335

 
Li, D-R., Murugan, A., and J.R. Falck: Enantioselective, Organocatalytic Oxy-Michael Addition to γ/δ-Hydroxy-α,β-enones: Boronate-Amine Complexes as Chiral Hydroxide Synthons.  J. Am. Chem. Soc., 2008; (130):46-48
 
Illies, C., Gromada, J., Fiume, R., Leibiger, B., Yu, J., Juhl, K., Yang, S-N., Barma, D., Falck, J.R., Saiardi, A., Barker, C.J., and P-O Berggren: Requirement of Inositol Pyrophosphates for Full Exocytotic Capacity in Pancreatic β Cells.  Science 2007; (318):1299-1302
 
Falck, J.R., He, A., Fukui, H., Tsutsui, H., and A. Radha: Synthesis and Stereochemical Assignment of FR252921, a Promising Immunosuppressant. Angew. Chem. Int. Ed. 2007; (46):4527-4529
 
Baati, R., Mioskowski, C., Kashinath, D., Kodepelly, S., Lu, B., and J.R. Falck: Stereoselective Synthesis of Methyl (Z)-α-methoxyacrylates via Two-Carbon Homologation of Aldehydes.  Tetrahedron Lett. 2009; (50):402-405
 
He, A., and J.R. Falck: Synthesis of Enantioenriched α-(Hydroxyalkl)-tri-n-butylstannanes.  Angew. Chem. Int. Ed. 2008; (47):6586-6589
 
Rasko, D.A., Moriera, C.G., Li, D.R., Readings, N.C., Ritchie, J.M., Waldor, M.K., William, N., Taussig, R., Wei, S., Roth, M., Hughes, D.T., Huntley, J.F., Fina, M.W., Falck, J.R., and V. Sperandio: Targeting QseC Signaling and Virulence for Antibiotic Development. Science 2008; (321):1078-1080
 
Lu, B., and J.R. Falck: Efficient Iridium-Catalyzed C-H Functionalization/Silylation of Heteroarenes.  Angew. Chem. Int. Ed. 2008; (47):7508-7510
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