Pharmacology and Toxicology

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Mike Tanner

Graduate Student
Department of Pharmacology and Toxicology

B.S., Carroll College Waukesha, WI
M.S., University of Illinois at Chicago, Chicago, IL

Faculty Advisor: Dr. Michael E. Widlansky, MD, MPH
Email: mjtanner@mcw.edu
Phone: (414) 955-7436


Research Interest

My research currently focuses on the dysfunction of the endothelium during hypoglycemic states of Type II diabetes patients. The endothelium is the single cell layer that lines the vasculature and acts as a barrier between the blood and the smooth muscle cells of vessels. It has many roles in vascular biology including clot formation, atherosclerotic regulations, and maintaining vascular tone through signaling efforts to the smooth muscle cells that control dilation and contraction. We look particularly at the effects of hypoglycemia on the endothelium’s ability to modulate vascular tone and hope to outline another source of vascular disease within diabetic patients. Instances of hypoglycemia occur most commonly in diabetic patients due to an overcompensation of high glucose levels via an intervention medication like insulin. The idea is that a patient takes insulin to lower blood glucose, but due to imprecision in dosing and pharmacological effects in vivo, the insulin can lower blood glucose too far into the range of hypoglycemia which can have equally negative effects according to our research.

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