2nd Year MSTP Student
Department of Pharmacology and Toxicology
B.A., Washington University, St. Louis, MO
Faculty Advisor: Dr. Carol Williams
Phone: (414) 955-5631
Changes in regulation of cell proliferation and migration are important in the formation of cancer. Small GTPases have been shown to be important regulators of both processes, and misregulation can lead to tumorigenesis and metastasis. Our laboratory has shown that SmgGDS is an important regulator of small GTPase cell signaling, especially regarding the prenylation of GTPases. I will be studying other functional and physical interactions of small GTPases with SmgGDS in the hopes of better understanding the cell signaling pathways leading to cancer.
Shokeen M, Zheleznyak A, Wilson JM, Jiang M, Liu R, Ferdani R, Lam KS, Schwarz JK, Anderson CJ. Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri. “Molecular Imaging of Very Late Antigen-4 (α4β1 Integrin) in the Premetastatic Niche.” J Nucl Med. 2012 May; 53(5):779-86. Epub 2012 Apr 10.
Zheleznyak A, Wadas TJ, Sherman CD, Wilson JM, Kostenuik PJ, Weilbaecher KN, Anderson CJ. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA. “Integrin α(v)β (3) as a PET Imaging Biomarker for Osteoclast Number in Mouse Models of Negative and Positive Osteoclast Regulation.” Mol Imaging Biol. 2012 Aug;14(4):500-8.