Pharmacology and Toxicology

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Haris G. Vikis, PhD

Assistant Professor
Phone: 414 955-7588
Fax: 414-955-6059
hvikis@mcw.edu

Education:
PhD, Biological Chemistry, University of Michigan, 2003

Dr. Vikis' Faculty Collaboration Database

 


Research Interest

Chronic Inflammation and Lung Tumorigenesis.

Although the causal relationship between inflammation, immunity, and cancer is widely accepted, many of the molecular and cellular mechanisms mediating this relationship remain uncharacterized. Neutrophils account for a significant portion of the inflammatory infiltrate found in a wide variety of cancers and may have a significant impact on the tumor microenvironment via their production of cytokines and chemokines.  In addition, reactive oxygen species produced by neutrophils may regulate cell proliferation, angiogenesis, and metastases. However, little is known about how neutrophil infiltration into the lung contributes to the development of lung cancer, making it difficult to identify mechanism(s) or potential targets for prevention and therapy development. Using a mouse model of inflammatory promotion of lung adenocarcinoma that employs the carcinogen 3-methylcholanthrene (MCA) and the tumor promoting lung inflammatory agent butylated hydroxytoluene (BHT), we recently reported that neutrophil infiltration into the lung is a major contributor of lung tumor development. Our goal is to determine the role of neutrophils in mediating these pro-tumorigenic inflammatory processes, and additionally evaluate pharmacologic interventions that could be employed as prevention or therapy in lung cancer. Currently, we are interested in elucidating the role of the macrophage-derived neutrophil chemokine KC/CXCL1, which mediates the recruitment and activation of neutrophils via the CXCR2 receptor, and the role of the neutrophil-derived oxidant generating enzyme myeloperoxidase.

 


Select publications:

Vikis HG, Jackson EN, Krupnick AS, Franklin A, Gelman AE, Chen Q, Piwnica-Worms D, You M. Strain- Specific Susceptibility for Pulmonary Metastasis of Sarcoma 180 Cells in Inbred Mice. Cancer Res. 2010 Jun 15;70(12):4859-67.

Lu Y, Liu P, James M, Vikis HG, Liu H, Wen W, Franklin A, You M. Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor. Oncogene. 2010 Feb 18;29(7):1041-9.

Liu PY, Vikis H, James M, Lu Y, Wang DL, Liu HB, Wen WD, Wang Y, You M. Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. Cancer Res. 2009 Aug 1;69(15):6290-8. Epub 2009 Jul 21.

Liu P, Vikis HG, Wang D, Lu Y, Wang Y, et al. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst. 2008 Sep 17;100(18):1326-30. Epub 2008 Sep 9.

Liu P, Vikis H, Lu Y, Wang D, and You M. Large-scale in Silico Mapping of Complex Quantitative Traits in Inbred Mice. PLoS ONE. 2007 Jul 25;2:e651.

Vikis H, Sato M, James M, Wang D, Wang Y et al. EGFR-T790M Is a Rare Lung Cancer Susceptibility Allele with Enhanced Kinase Activity. Cancer Res. 2007 May 15;67(10):4665-70.

Wang M, Vikis HG, Wang Y et al. Identification of a novel tumor suppressor gene p34 on human chromosome 6q25. 1 Cancer Res. 2007 Jan 1;67(1):93-9.

Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, Liu Y, You M. Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Nat Genet. 2006 Aug;38(8):888- 95. 2006 Jul 23.

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