Pharmacology and Toxicology

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Donghai Xiong, PhD

Assisatant Professor
Phone: 414 955-7589
Fax: 414-955-6059

PhD - Biomedical Sciences, Creighton University - 2007

Dr Xiong's Faculty Collaboration Database

Research Interest

Exons are short, functionally important sequences of DNA which represent the regions in genes that are translated into protein. It is estimated that the protein coding regions of the human genome constitute about 85% of the disease-causing mutations. Exome sequencing has taken centre stage in cancer profiling. My primary research interest is to utilize this state-of-the-art technology to analyze multiple tumor-normal pairs to identify the genes underlying lung cancer. Currently we have finished whole exome sequencing and analysis of 14 samples taken from both the lung cancer tissue and the adjacent normal tissue from each of the seven lung cancer subjects. By comparing the genetic variants called from tumor and normal samples, we identified a pool of candidate genes associated with lung cancer. We are also collaborating with TCGA (The Cancer Genome Atlas) to analyze additional 81 samples from 43 lung cancer patients using exome sequencing technology. The follow-up molecular validation of the identified genetic variants underlying lung cancer is also ongoing. Our aim is to find and confirm as many as possible the somatic mutations associated with lung cancer. I am particularly interested in developing and applying multiple statistical methods for the fast and robust identification of genetic mutations underlying human cancer.


Pathway-based genome-wide association analysis identified the importance of regulation of autophagy pathway for ultradistal radius BMD. (Zhang L et al.) J Bone Miner Res 2010 Jul;25(7):1572-80

Genome-wide association study for femoral neck bone geometry. (Zhao LJ et al.) J Bone Miner Res 2010 Feb;25(2):320-9

IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. (Guo Y et al.) J Bone Miner Res 2010 May;25(5):1042-8

Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry. (Chen Y et al.) Bone 2010 Jan;46(1):129-36

Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families. (Xu XH et al.) Osteoporos Int 2010 Jan;21(1):99-107

Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians. (Dong SS et al.) Calcif Tissue Int 2009 Aug;85(2):104-12

Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. (Liu YZ et al.) PLoS Genet 2009 Mar;5(3):e1000420

Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. (Liu XG et al.) Am J Hum Genet 2009 Mar;84(3):418-23

Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. (Xiong DH et al.) Am J Hum Genet 2009 Mar;84(3):388-98

Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15. (Liu YZ et al.) Mol Psychiatry 2009 Jul;14(7):668-80

Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation. (Lei SF et al.) Hum Mol Genet 2009 May 1;18(9):1661-9

Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. (Liu YZ et al.) PLoS One 2008;3(9):e3160

Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families. (Zhao LJ et al.) Hum Genet2008 Sep;124(2):171-7

A bivariate whole genome linkage study identified genomic regions influencing both BMD and bone structure. (Liu XG et al.) J Bone Miner Res 2008 Nov;23(11):1806-14

Comprehensive association analyses of IGF1, ESR2, and CYP17 genes with adult height in Caucasians. (Yang TL et al.) Eur J Hum Genet 2008 Nov;16(11):1380-7

Genetic determination of osteoporosis: lessons learned from a large genome-wide linkage study. (Xiong DH et al.) Hum Biol 2007 Dec;79(6):593-608

Quantitative trait loci mapping. (Xiong DH et al.) Methods Mol Biol 2008;455:203-35

Association study of the oestrogen signalling pathway genes in relation to age at natural menopause. (He LN et al.) J Genet 2007 Dec;86(3):269-76

The MTHFR gene polymorphism is associated with lean body mass but not fat body mass. (Liu X et al.) Hum Genet 2008 Mar;123(2):189-96

Sex-specific association of the glucocorticoid receptor gene with extreme BMD. (Peng YM et al.) J Bone Miner Res 2008 Feb;23(2):247-52

A whole genome linkage scan for QTLs underlying peak bone mineral density. (Zhang F et al.) Osteoporos Int 2008 Mar;19(3):303-10

Variations in RANK gene are associated with adult height in Caucasians. (Chen Y et al.) Am J Hum Biol 2007 Jul-Aug;19(4):559-65

A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis. (Tang ZH et al.) J Clin Endocrinol Metab 2007 Jul;92(7):2751-7

Genetic determination in onset age of wrist fracture. (Xiong D et al.) J Hum Genet 2007;52(6):481-4

Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in Caucasian females. (Zhao J et al.) Hum Reprod 2007 Jun;22(6):1789-94
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