Ming You, MD, PhD, joined the faculty at the Medical College of Wisconsin in the Department of Pharmacology and Toxicology in September 2010. He is currently the principal investigator or the co-principal investigator for multiple NIH grants that are focused on genetics and chemoprevention of lung cancer. Some ongoing projects in the You laboratory are the identification of candidate lung cancer susceptibility genes by capture-sequencing of targeted regions or genes, identification of frequent somatic mutations in lung adenocarcinomas and squamous cell carcinomas by exome sequencing, and identification of those somatic mutations predictive of clinical outcome of stage I NSCLC by SNP genotyping.
Dr. You is a member of the Board of Scientific Counselors of the National Cancer Institute. He is a current member and past chair of the Chemo/Dietary Prevention Study Section (CDP) and a member of the Chemical Pathology Study Section (CPA) at the National Institutes of Health. Dr. You also served as a member of the NCI’s Cancer Susceptibility Think Tank and Cancer Chemoprevention Think Tank and the chair of the Review Panel for Chemopreventive Agent Development Research Group (CADRG), Division of Cancer Prevention at the National Cancer Institute. He is an Associate Editor of Cancer Research and Cancer Prevention Research and is on the editorial board of PLoS One and Carcinogenesis.
In addition, Dr. Ming You is the Director of the Medical College of Wisconsin Cancer Center. Its stated mission is to reduce the cancer burden in Milwaukee area, Wisconsin, nationally, and internationally through research into its causes, prevention, early detection and treatment, and through integrated patient care and through education. Under the direction of Dr. You, the MCW Cancer Center strategic plan has identified these top five cancer research programs and related disease focus as Molecular Carcinogenesis & Chemoprevention, Cancer Cell Biology, Cancer Imaging, Transplantation Biology & Immunotherapy, and Population Science & Epidemiology.
He has lectured broadly and internationally in his areas of interest and expertise. His publications have focused on work in genetics and chemoprevention of lung cancer and his bibliography includes over 170 titles. He has mentored a large number of graduate students and post-doctoral fellows and has a large laboratory, including a number of research and tenure track faculty members.
Lung Cancer Chemoprevention
Susceptibility Genes for Rodent and Human Lung Cancer
Molecular Pathogenesis of Lung Cancer
Pan J, Zhang Q, Wang Y, You M. 26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro. PLoS One. 2010 Oct 11;5(10):e13298.
Wang Y, James M, Wen W, Lu Y, Szabo E, Lubet RA, You M. Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. Mol Cancer Ther. 2010 Nov;9(11):3074-82. Epub 2010 Nov 2.
James MA, Fu H, Liu Y, Chen DR, You M. Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. Mol Carcinog. 2011 50:1-7
Lu Y, Liu P, Wen W, Grubbs CJ, Townsend RR, Malone JP, Lubet RA, You M. Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models. Am J Transl Res. 2010 Sep 20;3(1):8-27.
Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Brant KA, Dopico RA, Di YP, Jang AS, Dietsch M, Medvedovic M, Li Q, Vuga LJ, Kaminski N, You M, Prows DR. Functional genomics of chlorine-induced acute lung injury in mice. Proc Am Thorac Soc. 2010, 7:294-6.
Vikis HG, Jackson EN, Krupnick AS, Franklin A, Gelman AE, Chen Q, Piwnica-Worms D, You M. Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice. Cancer Res. 2010, 70:4859-67.
C.I. Amos, S. M. Pinney, Y. Li, Kupert E, Lee J, M. A. de Andrade, P. Yang, A.G. Schwartz, P. Fain, A. Gazdar, J. Minna, J.S. Wiest, D. Zeng, H. Rothschild, D. Mandal, M. You, C. Gaba, J.E. Bailey-Wilson, M.W. Anderson. A gene-environment interaction influences risk for lung cancer in high risk families. Cancer Res. 2010; 70:2359-67.
Zhang Q, Fu H, Pan J, He J, Ryota S, Hara Y, Wang Y, Lubet RA, You M. Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice. Pharm Res. 2010, 27:1066-71.
Yian Wang, Weidong Wen, Yijun Yi, Zhongqiu Zhang, Ronald A. Lubet and Ming You. Preventive Effects of Bexarotene and Budesonide in a Genetically Engineered Mouse Model of Small Cell Lung Cancer. Cancer Prev Res. 2009, 2:1059-64.
Lubet RA, Yao R, Grubbs CJ, You M, Wang Y. Induced Expression of Drug Metabolizing Enzymes By Preventive Agents: Role of the Antioxidant Response Element. Chem Biol Interact. 2009, 182:22-8.
Yian Wang, Zhongqiu Zhang, Joel R. Garbow, Doug J. Rowland, Ronald A Lubet, Daniel Sit, Frances Law, and Ming You. Chemoprevention of Lung Squamous Cell Carcinoma in Mice by a Mixture of Chinese Herbs. Cancer Prev Res. 2009; 2:634-40.
Michael A. James, Yan Lu, Yan Liu, Haris G. Vikis and Ming You. RGS17, an Overexpressed Gene in Human Lung and Prostate Cancer, Induces Tumor Cell Proliferation Through the cAMP-PKA-CREB Pathway. Cancer Res. 2009; 69:2108-16.
Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, Steinbach JH, Stitzel JA, Anderson MW, You M, Stevens VL, Bierut LJ, Goate AM. Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Hum Mol Genet. 2009; 18:3125-35.
Anderson MW, Goodin C, Zhang Y, Kim S, Estensen RD, Wiedmann TS, Sekar P, Buncher CR, Khoury JC, Garbow JR, You M, Tichelaar JW. Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice. Carcinogenesis. 2008, 29:1594-600.
Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst. 2008, 100:1326-30.
Garbow JR, Wang M, Wang Y, Lubet RA, You M. Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging. Clin Cancer Res. 2008, 14:1363-7.
Wang Y, Zhang Z, Lu Y, Yao R, Jia D, Wen W, LaRegina M, Crist K, Lubet R, and You M. Enhanced Susceptibility to Chemical Induction of Ovarian Tumors in Mice with a Germ Line p53 Mutation. Mol Cancer Res, 2008, 6:99-109.
Lu Y, Yi YJ, Liu PY, Wen WD, James M, Wang DL, You M. Common human cancer genes discovery by integrated gene-expression analysis. PLoS One, 11: e1149
Yan Y, Tan Q, Wang Y, Wang D, Jin M, Gordon T, Lubet RA, You M. Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient mice. Inhal Toxicol. 2007; 19 Suppl 1:183-7.
Liu Y, Vikis HG, Yi Y, Futamura M, Wang Y, You M. Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. Cancer Res. 2007; 67:10207-13.