Pharmacology and Toxicology

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Gilbert C. White, II, MD

Executive Vice President for Research
Director, Blood Research Institute
BloodCenter of Wisconsin
Professor
Department of Medicine, Biochemistry and Pharmacology and Toxicology
Phone: 414 937-3866
Fax: 414-937-6284
gcwhite@bcw.edu

Dr. White's Faculty Collaboration Database

Research Interests

The overall goal of the White lab is to understand the signaling pathways that mediate the hemostatic responses of blood platelets. Understanding these responses at a molecular level permits the development of methods to selectively and precisely manipulate those pathways, thereby controlling vascular diseases like heart attacks and strokes. A current focus is the role of rap1b, a low molecular weight GTP binding protein member of the ras superfamily, which is present in high concentrations in platelets and plays a role in the activation in platelets, including platelet aggregation, the integrin-mediated interaction of one platelet with another to form a platelet hemostatic plug. Rap1b also plays a role in the inhibition of platelets by cyclic AMP. Thus, rap1b appears to be positioned as a unique and critical bi-directional modulator of platelet activation. Using knock-out and transgenic mice combined with proteomic and genetic approaches like yeast two-hybrid screening, we are exploring the pathway(s) by which rap1b and other proteins mediate signals from G-protein coupled receptors such as P2Y12 to integrins like aIIbb3 that mediate platelet aggregation. We are also exploring the pathway(s) that link cyclic AMP and rap1b. Understanding the rap1b-dependent pathways that are involved in mediating platelet responses will provide new ways to control platelet in vascular diseases.

 

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