Radiation Oncology

X. Allen Li, PhD, DABMP, FAAPM Professor and Chief of Medical Physics Department of Radiation Oncology 8701 Watertown Plank Road Milwaukee, WI 53226 (414) 805-4362 phone (414) 805-4354 fax ali@mcw.edu

Curriculum Vitae

Research Interests

• Adaptive radiation therapy
• Biological modeling for radiation treatment planning
• Anatomical/biological/functional imaging guided radiotherapy planning and delivery
• Monte Carlo application to radiotherapy dosimetry

Education

• PhD, Electron Paramagnetic Resonance, Department of Physics, Concordia University, Montreal, Quebec, Canada (1989-1992).
• MS, Electron Optics and Electron Microscopy, Department of Physics, Yunnan University, Kunming, China (1983-1986).
• BS, Electron Physics, Department of Physics, Yunnan University, Kunming, China (1979-1983).

Training

• Clinical Physics Resident, Ottawa Regional Cancer Centre, Ottawa, Canada (1993-1994).
• Postdoctoral Fellow, Ionizing Radiation, National Research Council Canada, Ottawa, Canada (1992-1993).

Certifications

• Medical Physics-Radiation Oncology Physics, American Board of Medical Physicists (2001).
• Medical Physics-Radiation Oncology Physics, Canadian College of Physicists in Medicine (1994).

Representative Publications (last 5 years)

• Paulson ES, Bradley JA, Wang D, Ahunbay EE, Schultz C, Li XA. Internal margin assessment using cine MRI analysis of deglutition in head and neck cancer radiotherapy. Med Phys 38(4):1740-7, 2011.
• Peng C, Chen G, Ahunbay E, Wang D, Lawton C, Li XA. Validation of an online replanning technique for prostate adaptive radiotherapy. Phys Med Biol 56(12):3659-68, 2011.
• Ahunbay EE, Robbins J, Christian R, Godley A, White J, Li XA. Interfractional target variations for partial breast irradiation. Int J Radiat Oncol Biol Phys May 11 [Epub ahead of print], 2011.
• Qi XA, Hu A, Wang K, Crosby M, Hu B, White J, Li XA. Respiration induced heart motion and indications of gated delivery for left-sided breast irradiation. Int J Radiat Oncol Biol Phys Apr 12 [Epub ahead of print], 2011.
• Qi XS, White J, Li XA. Is α/β for breast cancer really low? Radiother Oncol Feb 28 [Epub ahead of print], 2011.
• Bradley JA, Paulson ES, Ahunbay E, Schultz C, Li XA, Wang D. Dynamic MRI analysis of tumor and organ motion duirng rest and deglutition and margin assessment for radiotherapy of head and neck cancer. Int J Radiat Oncol Biol Phys Feb 5 [Epub ahead of print], 2011.
• Cui Y, Galvin JM, Staube WL, Bosch WR, Purdy JA, Li XA, Xiao Y. Multisystem verification of registrations for image-guided radiotherapy in clinical trials. Int J Radiat Oncol Biol Phys Jan 13 [Epub ahead of print], 2011.
• Allozi R, Li XA, White J, Apte A, Tai A, Michalsi JM, Bosch WR, El Naqa I. Tools for consensus analysis of experts' contours for radiotherapy structure definitions. Radiother Oncol, 97(3):572-578, 2010.
• Qi XS, White J, Rabinovitch R, Merrell K, Sood A, Bauer A, Wilson JF, Miften M, Li XA. Respiratory organ motion and dosimetric impact on breast and nodal irradiation. Int J Radiat Oncol Biol Phys 78(2):609-17, 2010.
• Ahunbay EE, Peng C, Holmes S, Godley A, Lawton C, Li XA. Online adaptive replanning method for prostate radiotherapy. Int J Radiat Oncol Biol Phys 77(5):1561-72, 2010.
• Pan CC, Kavanagh BD, Dawson LA, Li XA, Das SK, Miften M, Ten Haken RK. Radiation-associated liver injury.Int J Radiat Oncol Biol Phys 76(3 Suppl):S94-100, 2010
• Lawrence YR, Li XA, el Naqa I, Hahn CA, Marks LB, Merchant TE, Dicker AP. Radiation dose-volume effects in the brain. Int J Radiat Oncol Biol Phys 76(3 Suppl):S20-7, 2010.
• Dawson LA, Kavanagh BD, Paulino AC, Das SK, Miften M, Li XA, Pan C Ten Haken RK, Schultheiss TE. Radiation-associated kidney injury Int J Radiat Oncol Biol Phys 76(3 Suppl):S108-15, 2010.
• Kavanagh BD, Pan CC, Dawson LA, Das SK, Li XA Ten Haken RK, Miften M. Radiation dose-volume effects in the stomach and small bowel. Int J Radiat Oncol Biol Phys 76(3 Suppl):S101-7, 2010.
• Tai A, Christensen JD, Gore E, Khamene A, Boettger T Li XA. Gated treatment delivery verification with on-line megavoltage fluoroscopy. Int J Radiat Oncol Biol Phys 75(5):1592-8, 2010.
• Zhu TC, Ahnesjo A, Lam KL, Li XA, Ma CM, Palta JR, Sharpe MB, Thomadsen B, Tailor RC; AAPM Therapy Physics Committe Task Group 74. Report of AAPM Therapy Physics Committee Task Group 74: In-air output ratio Sc. for megavoltage photon beams. Med Phys 36(11):5261-91, 2009.
• Ghosh SN, Zhang R, Fish BL, Semenenko VA, Li XA, Moulder JE, Jacobs ER, Medhora M. Renin-angiotensin system suppression meitgates experimental radiation pneumonitis. Int J Radiat Oncol Biol Phys 56(5):1528-36, 2009.
• Ahunbay EE, Peng C, Godley A, Schultz C, Li XA. An online replanning method for head and neck adaptive radiotherapy. Med Phys 36(10):4776-90.
• Qi XS, Semenenko VA, Li XA. Improved critical structure sparing with biologically based IMRT optimization.  Med Phys, 36(5):1790-9, 2009.  
• Godley A, Ahunbay E, Peng C, Li XA.  Automated registration of large deformations for adaptive radiation therapy of prostate cancer.  Med Phys, 36(4):1433-41, 2009. 
• Qi ZY, Den XW, Huang SM, Zhang L, He ZC, Li XA, Kwan I, Lerch M, Cutajar D, Metcalfe P, Rosenfeld A.  In vivo verification of superficial dose for head and neck treatments using intensity modulated techniques.  Med Phys, 36(1):2009. 
• Li XA, Tai A, Arthur D, Buchholz T, MacDonald S, Marks L, Pierce L, Taghian A, Vicini F, Woodward W, White J.  Variability of target and normal structure delineation for breast-cancer radiotherapy: a RTOG multi-institutional and multi-observer study. Int J Radiat Oncol Biol Phys, 73(3):944-51, 2009.
• Tai A, Erickson B, Li XA, Extrapolation of normal tissue complication probability for different fractionations in liver irradiation Int J Radiat Oncol Biol Phys, 74(1):283-9, 2009.
• Kainz K, White J, Herman J, Li XA, Investigation of helical TomoTherapy for partial-breast irradiation of prone-positioned patients. Int J Radiat Oncol Biol Phys, 74(1):275-82, 2009.
• Semenenko VA, Reitz B, Day E. Qi XS, Miften M, Li XA.  Evaluation of a commercial biologically based IMRT treatment planning system.  Med Phys, 35(12):5851-60, 2008. 
• Li XA, Wang JZ, Stewart RJ, DiBiase SJ, Wang D, Lawton C.  Designing equivalent treatment regimens for prostate radiotherapy using equivalent uniform dose. Br. J. Radiol. 81, 59-68, 2008.
• Das IJ, Cheng CW, Ahnesjö A, Gibbons J, LI XA, Lowenstein J, Mitra RK, Simon WE, Watts RJ. Zhu TC.  Report of AAPM Radiation Therapy Committee Task Group 106: Accelerator beam data commissioning equipment and procedures. Med. Phys. 35, 4186-4215, 2008.
• Tai A, Erickson B, Khater K, Li X.A. Estimate of radiobiological parameters from clinical data for biologically based treatment planning for liver irradiation. Int J Radiat Oncol Biol Phys, 70, 900-907, 2008.
• Wang JZ, Rhee JG, Shi P, Stewart RD, Li X.A.  In vitro Determination Radiation Sensitivity Parameters for DU-145 Prostate Cancer Cells. Int. J. Radiat. Biol., 84, 515–522, 2008.
• Semenenko VA, Li XA. Lyman NTCP model parameters for radiation pneumonitis and xerostomia based on combined analysis of published clinical data. Phys. Med. Biol., 53, 737-755, 2008.
• Semenenko VA, Molthen RC, Li C, Morrow NV, Li R, Ghosh SN, Medhora MM, Li XA.  Irradiation of varying volumes of rat lung to same mean lung dose: A little to a lot or a lot to a little? Int J Radiat Oncol Biol Phys. 71, 838-47, 2008.
• Hsiao Y, Stewart RD, Li, XA. A Monte-Carlo derived dual-source model for helical Tomotherapy treatment planning. Tech. Can. Res. & Tr. 7, 141, 2008.
• Chen G, Ahunbay E, Li XA. Automated computer optimization for 3D treatment planning of breast irradiation. Med. Phys. 35, 2253-58, 2008.
• Zhao L, Sandison G, Farr J, His W, Li XA. Dosimetric evaluation of MIP-based patient aperture and compensator designs to treat lung cancer using proton therapy under free breathing conditions. Phys. Med. Biol. 53, 3343-3364, 2008.
• Ahunbay E, Chen G, Peng C, Yu C, Narayanan S, Lawton C. Li XA, An on-line adaptive planning strategy for inter-fraction image guidance. Med. Phys. 35, 3607-3615, 2008.
• Yang Q, Feng Y, Schultz CJ, Li XA, Wu H, Wang D. Synergistic effect of 15-lipoxygenase 2 and radiation in killing head-and-neck cancer. Cancer Gene Ther. 15, 323-30, 2008.
• Semenenko VA, Reitz B, Day E, Qi XS, Miften M, Li XA.  Evaluation of a Commercial Biologically Based IMRT Treatment Planning System, Med. Phys, 35, 5851-5860, 2008.
• Peng C. Kainz K, Lawton C, Li X.A. A comparison of daily megavoltage ct and ultrasound image guided radiation therapy for prostate cancer. Med. Phys. 35, 5619-5628 2008.
• Qi, XS, Schultz, CJ, Li, XA.  Possible fractionation regimens for treatment of large size arteriovenous malformation using IG-IMRT. Phys. Med. Biol. 52, 5667-5682, 2007.
• Chen, GP, Ahunbay E, Schultz CJ, Li, XA. Development of an inverse optimization package to plan non-uniform dose distributions based on spatially inhomogeneous radiosensitivity extracted from biological images, Med. Phys. 34, 1198-1405, 2007.
• Ahunbay E, Chen GP, Jursinic,P, White J, Thatcher S, Albano K, Li XA. Direct aperture optimization based IMRT for whole breast irradiation.  Int J Radiat Oncol Biol Phys, 67, 1248-1258, 2007.
• Morrow, N.V., Stepaniak, C., White, J., Wilson, J.F., LI, X.A.:  Inter- and intra-fractional uncertainties for prone breast irradiation.  Int J Radiat Oncol Biol Phys, 69, 910-917, 2007.
• Li XA, Hendee RW.  Radiation Oncology physicists will need to better understand medical imaging. J. Am Coll Radiol, 4, 40-44, 2007.
• Li, XA, Qi,XS, Pitterle M, Kalakota K, Mueller K, Jursinic PA, Erickson BA, Wang D, Schultz CJ,  Firat SY, Wilson, JF:  Inter-fractional variations in patient setup and anatomic change assessed by daily CT from helical tomotherapy.  Int J Radiat Oncol Biol Phys, 68, 581-591, 2007.
• Bovi J, Qi SX, White J, Li XA. Comparison of three partial breast irradiation techniques: treatment effectiveness based upon biological models. Radiother. & Oncol, 84, 226-232, 2007.
• Ahunbay E, Li XA. Investigation of the reliability, accuracy and efficiency of gated IMRT delivery with a commercial linear accelerator. Med. Phys, 34, 2928-2938, 2007.
• Cohen EP, Fish BL, Sharma M, Li XA, Moulder JE.  Angiotensin II blockade in radiation nephropathy: the role of the AT₂ receptor.  Translational Research, 150, 106-115, 2007.