Radiation Oncology

Meetha M. Medhora, PhD Associate Professor of Medicine Director of Research, Division of Pulmonary and Critical Care      Department of Medicine Associate Director, Center for Countermeasures Against Radiation      Department of Radiation Oncology Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee, WI 53226 mmedhora@mcw.edu

Curriculum Vitae

Research Interests

• Mitigation of radiation injury to the lungs
• Vasoreactive and antiapoptotic actions of epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE, products of the essential fatty acid, arachidonic acid

Education

• PhD, Molecular Biology, Jawaharial Nehru University, New Dehli, Inda (1984).
• MS, Life Sciences, Jawaharlal Nehru University, New Dehli, India (1979).
• BS, Human Physiology, Physics and Chemistry, First Class Presidency College, University of Calcutta, India (1977).

Training

• Research Assoicate, Renal Division, Jewish Hospital at Washington University Medical Center, St. Louis, MO (1990-1994).
• Postdoctoral Fellow, Department of Genetics, Washington School of Medicine, St. Louis, MO (1984-1990).

Representative Publications (last 5 years)

• Kma L, Gao F, Fish BL, Moulder JE, Jacobs ER, Medhora M. Angiotensin Converting Enzyme Inhibitors Mitigate Collagen Synthesis Induced by a Single Dose of Radiation to the Whole Thorax. Journal of Radiation Research (Japan) (in press).
• Rosenthal RA, Fish B, Hill RP, Huffman KD, Lazarova Z, Mahmood J, Medhora M, Molthen R, Moulder JE, Sonis ST, Tofilon PJ, Doctrow SR. Salen mn complexes mitigate radiation injury in normal tissues. Anticancer Agents Med Chem. 11(4):359-72, 2011.
• Leverence JT, Medhora M, Konduri GG, Sampath V. Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCζ-mediated p47phox phosphorylation. Chem Biol Interact. 189(1-2):72-81, 2011. PMID: 20920494
• Pfister S, Somberg L, Lowry T, Gao Y, Medhora M, Jacobs ER. Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis. J Thorac Cardiovasc Surg. 141(2):425-31, 2011. PMID: 21075383.
• Liu Y, Wang R, Li J, Rao J, Li W, Falck JR, Manthati VL, Medhora M, Jacobs ER, Zhu D. Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs. Hypertens Res, 34(5):630-9, 2011. PMID: 21307870.
• Ma J, Zhang L, Li S, Liu S, Ma C, Li W, Falck JR, Manthati VL, Reddy DS, Medhora M, Jacobs ER, Zhu D. 8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway. Exp Cell Res. 316(14):2340-2353, 2010.
• Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM. Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. Connect Tissue Res, 52(2):139-46, 2010. PMID: 20604715.
• Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB, McBride WH. Animal models for medical countermeasures to radiation exposure.  Radiation Research 173(4):557-578, 2010.
• Ghosh SN, Wu Q, Mäder M, Fish BL, Moulder JE, Jacobs ER, Medhora M, Molthen RC. Vascular injury after whole thoracic x-ray irradiation in the rat.  International Journal of Radiation Biology Oncology Physics. 74(1):192-199, 2009.  PMID 19362237.
• Sharma M, McCarthy ET, Reddy DS, Patel PK, Savin VJ, Medhora M, Falck JR. 8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier.  Prostaglandins Other Lipid Mediat. 89(1-2):43-51, 2009. PMID 19480064.
• Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM. (2009).  Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. J Mol Cell Cardiol. 46(6):978-988.  PMCID: PMC2796716.
• Dhanasekaran A, Bodiga S, Gruenloh S, Gao Y, Dunn L, Falck JR, Buonaccorsi JN, Medhora M, Jacobs ER. 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. Am J Physiol Heart Circ Physiol. 296(3):H777-786, 2009. PMID 19136601.
• Zhang R, Mio Y, Pratt PF, Lohr N, Warltier DC, Whelan HT, Zhu D, Jacobs ER, Medhora M, Bienengraeber M. Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism. J Mol Cell Cardiol. 46(1):4-14, 2009. PMID 18930064.
• Ghosh SN, Zhang R, Fish BL, Semenenko VA, Li XA, Moulder JE, Jacobs ER, Medhora M. Renin-Angiotensin System Suppression Mitigates Experimental Radiation Pneumonitis.  Journal of Radiation Biology Oncology Physics. 75:1528-1536, 2009.
• Szabo S, Ghosh SN, Fish BL, Bodiga S, Tomic R, Kumar G, Morrow NV, Moulder JE, Jacobs ER, Medhora M. Cellular Inflammatory Infiltrate in Pneumonitis Induced by a Single Moderate Dose of Thoracic X-Irradiation in Rats.  Radiation Research. 173(4):545-556, 2009.
• Medhora M, Jacobs ER, Molthen R, Swarajit N. Ghosh, SN, Zhang R, Fish BL, Moulder JE. Radiation-induced lung injury: Mechanisms and countermeasure development.Indian Journal of Radiation Research, 6: 28-30, 2009.
• Dhanasekaran A, Gruenloh SK, Buonaccorsi JN, Zhang R, Gross GJ, Falck JR, Patel PK, Jacobs ER, Medhora MM. Multiple anti-apoptotic targets of the PI3K-Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. American Journal of Physiology 294(2):H724-H735, 2008. PMID 18055514.
• Medhora MM, Chen Y, Gruenloh SK, Harland D, Bodiga S, Zielonka J, Gebremedhin D, Gao Y, Falck JR, Anjaiah S, Jacobs ER. 20-HETE increases superoxide production and NADPH oxidase in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 294(5):L902-L911, 2008. PMID 18296498.
• Semenenko VA, Molthen RC, Li C, Morrow NV, Li R, Ghosh SN,  Medhora M, Li XA. Irradiation of varied volumes of rat lung to the same mean lung dose: a little to a lot or a lot to a little? International Journal of Radiation Biology Oncology Physics. 71(3):838-847, 2008. PMID 18439765.
• Zhang R, Ghosh SN, Zhu D, North PE, Fish BL, Morrow NV, Lowry T, Nanchal R, Jacobs ER, Moulder JE, Medhora M. Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: injury and recovery. International Journal of Radiation Biology. 84(6):487-497, 2008. PMID 18470747.
• Ionova IA, Vásquez-Vivar J, Whitsett J, Herrnreiter A, Medhora M, Cooley BC, Pieper GM. Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. Am J Physiol Heart Circ Physiol. 295(5):H2178-H2187, 2008. PMID 18835915.
• Medhora M, Dhanasekaran A, Pratt PF Jr, Cook CR, Dunn LK, Gruenloh SK, Jacobs ER. Role of JNK in network formation of human lung microvascular endothelial cells. American Journal of Physiology, Lung Cell Molecular Physiology. 294(4):L676-L 685, 2008. PMID: 18263671
• Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, FalckJR, Jacobs ER, Pratt PF. Emerging Mechanisms for Growth and Protection of Cardiovascular Tissue by Cytochrome P450-Derived Products of Arachidonic Acid and Other Eicosanoids.  Prostaglandins and Other Lipid Mediators 82 :19-29, 2007.