Radiation Oncology

EmailEmail    |   Bookmark Page Bookmark  |   RSS Feeds RSS  |   Print Page Print  

Static Electric and Magnetic Fields and Human Health


Last complete update: 13-Aug-2006
Version: 4
Author: John Moulder, Professor of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisc, U.S.A.
Address: jmoulder at mcw dot edu



  • This document reviews the laboratory and epidemiological evidence relevant to the issue of whether static (direct current, DC) magnetic or electric fields cause or contribute to cancer (or any other health problems) in humans.
  • This FAQ was designed for Netscape v7.2 and HTML version 4 transitional.
  • This FAQ is derived from an FAQ of the same name that was developed in the sci.med.physics newsgroup of USENET.

GO TO: Questions and Answers | Bibliography | HOME


WARNING:
This document is no longer being actively maintained.


Table of Contents

  1. Does anyone think that static electric or magnetic fields cause cancer or any other human health problems?
  2. Are all electromagnetic fields the same?
  3. Do we have to consider electromagnetic radiation as well as electromagnetic fields?
  4. Do we have to consider the electric as well as the magnetic component of the field?
  5. What units are used to measure static magnetic fields?
  6. What sort of static magnetic fields are common in residences?
  7. What sort of static magnetic fields are common in workplaces?
  8. What is known about the relationship between occupational exposure to static magnetic fields and cancer?
  9. How do scientists determine whether an environmental agent, such as a static electric or magnetic field causes or contributes to the development of cancer?
  10. How strong is the epidemiological evidence for a causal association between static fields and cancer?
  11. How could laboratory studies be used to help evaluate the possible relationship between static magnetic fields and cancer?
  12. Are static magnetic fields genotoxic?
  13. Do static magnetic fields enhance the effects of other genotoxic agents?
  14. Do laboratory studies indicate that static magnetic fields have any biological effects that might be relevant to cancer or other human health hazards?
  15. Do static magnetic fields show any reproducible biological effects in laboratory studies?
  16. Do static magnetic fields of the intensity encountered in occupational settings show reproducible biological effects?
  17. Are there known mechanisms that would explain how static magnetic fields of the intensity encountered in occupational settings could cause biological effects in humans?
  18. How does the sum of the laboratory and epidemiological evidence relevant to a connection between static magnetic fields and cancer stand up to the Hill criteria?
  19. Have any independent bodies reviewed the research on static electric and magnetic fields and possible human health effects?
  20. Do exposure standards for static electric and magnetic fields exist?
  21. What is the basis for the safety standards set by ACGIH, ICNIRP and the European Union?
  22. Do static fields affect cardiac pacemakers?
  23. Do static fields decrease fertility, cause birth defects or increase miscarriage rates?
  24. Could static field sources (like DC powerlines) cause health effects by creating or attracting ionized particles or chemicals?
  25. Bibliography

Source: http://www.mcw.edu/gcrc/cop/static-fields-cancer-faq/toc.html


What's New

This section summarizes material published since the last complete update.

  • There have been no updates

Acknowledgments:

Initial conversion of the FAQ into html was done by Bob Mueller and Dennis Taylor of the General Clinical Research Center at the Medical College of Wisconsin.


Questions and Answers


GO TO: Table of Contents | Bibliography | HOME


1) Does anyone think that static electric or magnetic fields cause cancer or any other human health problems?

While most public concern about electromagnetic (EM) fields and cancer has concentrated on power-frequency, microwave (MW) and radiofrequency (RF) fields, claims have been made that static magnetic fields cause or contribute to cancer.

There is very little theoretical reason to suspect that static fields might cause or contribute to cancer or any other human health problems (Q17), and there is very little laboratory (Q11-Q16, Q23) or epidemiological evidence (Q8-Q10, Q23) for a connection between static fields and human health hazards.

However, a workshop held by the World Health Organization (WHO) in 2004 [131] concluded that:

"...scientific research can provide some measure of confidence that short-term, acute exposures up to about 1-2 T [1000-2000 milliT] should be safe... However, it is not possible to determine whether there are any long-term health consequences even from exposure in the milliT range because, to date, there are no well-conducted epidemiological studies with sufficient power to be able to come to any conclusion on this, and there are no good long-term animal studies."
"While there are huge benefits to be gained from use of static magnetic fields, particularly in medicine, possible adverse health effects from exposure to them must be properly evaluated so that the true risks and benefits can be assessed. This said, WHO does not want to imply that all use of these fields should be unnecessarily restricted until appropriate research has been conducted and safety assured. An analysis of the interaction mechanisms suggests that short-term health effects can be predicted and so avoided. Further, there is no currently understood mechanism that would appear to lead to any long-term adverse health consequence."

2) Are all electromagnetic fields the same?

No. The nature of the interaction of biological material with an electromagnetic source with depends on the frequency of the source, so that different types of electromagnetic sources must be evaluated separately.

X-rays, ultraviolet (UV) light, visible light, radiofrequency (RF) energy, microwaves, magnetic fields from electrical power systems (power-frequency fields), and static magnetic fields are all electromagnetic energy; but they have different frequencies.

The frequency of an electromagnetic source is the rate at which the electromagnetic field changes direction and/or amplitude and is usually given in Hertz (Hz) where 1 Hz is one change (cycle) per second. The frequency and wavelength are related, and as the frequency rises the wavelength gets shorter. Power-frequency fields are 50 or 60 Hz and have a wavelength of about 5000 km. By contrast, microwave ovens have a frequency of 2.54 billion Hz and a wavelength of about 10 cm, and X-rays have frequencies of 10^15 Hz and, and wavelengths of much less than 100 nm. Static fields, or direct current (DC) fields do not vary regularly with time, and can be said to have a frequency of 0 Hz and an infinitely long wavelength.

We usually talk about the electromagnetic sources as though they produced waves of energy. This is not strictly correct, because sometimes electromagnetic energy acts like particles rather than waves; this is particularly true at high frequencies. The particle nature of electromagnetic energy is important because the energy per particle (or photons, as these particles are called) is important for determining what biological effects electromagnetic energy will have [62].

At the very high frequencies characteristic of hard UV and X-rays, electromagnetic particles (photons) have sufficient energy to break chemical bonds. This breaking of bonds is termed ionization, and this part of the electromagnetic spectrum is termed ionizing. The well-known biological effects of X-rays are associated with the ionization of molecules. At lower frequencies, such as those characteristic of visible light, RF energy, and microwaves, the energy of a photon is very much below those needed to disrupt chemical bonds. This part of the electromagnetic spectrum is termed non-ionizing. Because non-ionizing electromagnetic energy cannot break chemical bonds there is no analogy between the biological effects of ionizing and nonionizing electromagnetic energy [62].

Non-ionizing electromagnetic sources can still produce biological effects. Many of the biological effects of soft UV, visible, and IR frequencies also depend on the photon energy, but they involve electronic excitation rather than ionization, and do not occur at frequencies below that of IR (below 3 x 10^11 Hz). RF and MW sources can cause effects by inducing electric currents in tissues, which cause heating. The efficiency with which an electromagnetic source can induce electric currents, and thus produce heating, depends on the frequency of the energy, and the size and orientation of the object being heated. At frequencies below that used for broadcast AM radio (about 10^6 Hz), electromagnetic sources couple poorly with the bodies of humans and animals, and thus are very inefficient at inducing electric currents and causing heating [62].

Thus in terms of potential biological effects the electromagnetic spectrum can be divided into four portions:

  1. The ionizing radiation portion, where direct chemical damage can occur (X-rays).
  2. The non-ionizing portion of the spectrum, which can be subdivided into:
    1. The optical radiation portion, were electron excitation can occur (visible light, infrared light)
    2. The portion where the wavelength is smaller than the body, and heating via induced currents can occur (MW and higher-frequency RF).
    3. The portion where the wavelength is much larger than the body, and heating via induced currents seldom occurs (lower-frequency RF, power frequencies, static fields).

3) Do we have to consider electromagnetic radiation as well as electromagnetic fields?

No. Static electromagnetic sources do not produce radiation.

In general, electromagnetic sources produce both radiant energy (radiation) and non-radiant energy (fields). Radiated energy exists apart from its source, travels away from the source, and continues to exist even if the source is turned off. Fields are not projected away into space, and cease to exist when the energy source is turned off. For static electromagnetic fields there is no radiative component.


4) Do we have to consider the electric as well as the magnetic component of the field?

Probably not. The magnetic field component appears to be much more relevant to possible health effects.

Magnetic fields are difficult to shield, and easily penetrate buildings and people. In contrast to magnetic fields, electrical fields have very little ability to penetrate skin or buildings. Because static electric fields do not penetrate the body, it is generally assumed that any biologic effect from routine exposure to static fields must be due to the magnetic component of the field, or to the electric fields and currents that these magnetic fields induce in the body [1, 54].


5) What units are used to measure static magnetic fields?

Static magnetic fields are generally measured in Tesla (T), milliTesla (mT), and microTesla (microT, µT) where:

1000 mT = 1 T
1000 (µT) = 1 mT.

In the US, fields are sometimes still measured in Gauss (G) and milliGauss (mG), where:

10,000 G equals 1 T
1 G = 100 microT
1 microT (µT) = 10 mG.

In the FAQ, mT (millitesla) will be the preferred term.

Magnetic fields can be measured either as magnetic flux density or as magnetic field strength. In the US and Western Europe field strengths are usually specified in units of magnetic flux density (Tesla or Gauss). In some of the Eastern European literature, however, magnetic fields are specified in Oersteds (Oe), which are units of magnetic field strength. When dealing with exposure of non-ferromagnetic material, such as animals or cells, magnetic flux density and magnetic field strength can be assumed to be equal, so:

1 Oersted = 1 Gauss = 100 microT = 0.1 mT

6) What sort of static magnetic fields are common in residences?

Residential and environmental exposure to static magnetic fields is dominated by the Earth's natural field, which ranges from 0.03 to 0.07 milliT, depending on location. Static magnetic fields under direct current (DC) transmission lines are about 0.02 milliT. Small artificial sources of static fields (permanent magnets) are common, ranging from the specialized (audio speakers components, battery-operated motors, microwave ovens) to trivial (refrigerator magnets). These small magnets can produce fields of 1-10 milliT within a cm or so of their magnetic poles. The highest static magnetic field exposures to the general public are from magnetic resonance imaging (MRI), where the fields range from 150-4000 milliT [1, 2].

Direct effects on ferromagnetic objects and electronic equipment are the only things that most people would notice below about 1000 milliT. There is really no threshold for effects on ferromagnetic objects; a good compass will twitch at fields as low as 0.01 milliT, but it takes a much larger field (above 1 milliT) to make ferromagnetic objects move in a dangerous way. Electronics can be affected by quite low fields; a high resolution color monitor, for example, can show color distortions at static fields as low as 0.1 milliT.

A source of exposure to static fields that blurs the distinction between residential and occupational exposure is electric trains. Static fields in electric trains can be as high as 0.2 milliT [80].


7) What sort of static magnetic fields are common in work places?

Persons with occupational exposures to static fields include operators of magnetic resonance imaging (MRI) units, personnel in specialized physics and biomedical facilities (for example, those working with particle accelerators), and workers involved in electrolytic processes such as aluminum production. Some aluminum manufacturing workers are reported to be exposed to fields of 5-15 milliT for long periods of time, with maximum exposures up to 60 milliT [2, 3]; but another study reports average fields of only 2-4 milliT [4]. Workers in plants using electrolytic cells are reported to be exposed to fields of 4-10 milliT for long periods of time, with maximum exposures up to 30 milliT [5, 6]. Individuals working with particle accelerators are exposed to fields above 0.5 milliT for long periods of time, with exposures above 300 milliT for many hours, and maximum exposures of up to 2,000 milliT [7].

Another source of exposure to static magnetic fields is the residual fields that can remain after strong static magnets are removed. For example, after a clinical MRI unit is removed from a room, a residual field of as high as 2 milliT may remain from steel in the structure that has been permanently magnetized. Such fields are not sufficiently strong to be a concern for human health, but they may be strong enough to interfere with the operation of sensitive electronic equipment. These residual fields can be reduced (although not always eliminated) by professional "degaussing".


8) What is known about the relationship between occupational exposure to static magnetic fields and cancer?

There have been relatively few studies of cancer incidence in workers exposed to static magnetic fields. Budinger et al [7] found no excess cancer in workers exposed to 300 milliT fields from particle accelerators, and Barregard et al [6] found no excess cancer in workers exposed to 10 milliT fields in a chlorine production plant.

There are also studies of aluminum reduction plant workers [8, 9, 10, 61]. In general the studies of aluminum reduction plant workers were not designed to analyzed the effects of static fields, but these workers are exposed to static fields of 5-15 milliT [2, 3, 4]. In the aluminum reduction plant studies, the only excess cancer reported was lymphoreticular tumors, and this was seen in one study [8]. The only aluminum reduction plant study to look specifically at static field exposure and cancer reported no excess of nervous system or hematopoietic cancers [61].


9) How do scientists determine whether an environmental agent, such as a static electric or magnetic field causes or contributes to the development of cancer?

There are certain widely accepted criteria [11, 63, 64], often called the "Hill criteria" [11], that are weighed when assessing epidemiological and laboratory studies of agents that may cause human cancer. Under these criteria one examines the strength, consistency, and specificity of the association between exposure and the incidence of cancer, the evidence for a dose-response relationship, the laboratory evidence, the biological plausibility of the association, and the coherence of the proposed association with what is known about the agent and about cancer.

  1. Strength of association: whether there a clear increase in cancer incidence associated with exposure. The excess cancer found in epidemiological studies is usually quantified in a number called the relative risk (RR). This is the incidence of cancer in an "exposed" population divided by the incidence of cancer of an "unexposed" population. Since no one is unexposed to static fields, the comparison is actually "high exposure" versus "low exposure". A RR of 1.0 means no effect, a RR of less than 1.0 means a decreased incidence of cancer in the exposed group, and a RR of greater than 1.0 means an increased incidence of cancer in the exposed group. A strong association is one with a RR of 5 or more. Tobacco smoking, for example, shows a RR for lung cancer 10-30 times that of non-smokers.
  2. Consistency: whether most studies show about the same increased incidence of the same type of cancer. Using the smoking example, essentially all studies of smoking and cancer have shown an increased incidence of lung and head-and-neck cancers.
  3. Exposure-response relationship: whether cancer incidence increases when the exposure increases. Again, the more a person smokes, the higher the increased incidence of lung cancer.
  4. Laboratory evidence: whether there is there experimental evidence suggesting that the cancer is associated with exposure. Epidemiological associations are greatly strengthened when there is laboratory evidence to support such an association.
  5. Plausible biological mechanisms: whether there are any biological data or biophysical mechanisms that suggests that there should be an association between the agent and cancer. When it is understood how something causes disease, it is much easier to interpret ambiguous epidemiology. For smoking, while the direct laboratory evidence connecting smoking and cancer was weak at the time of the Surgeon General's report, the association was highly plausible because there were known cancer-causing agents in tobacco smoke.
  6. Coherence: whether the association between exposure to an agent and cancer is consistent with other things that we know about the biophysics of the agent and the biology of cancer.

These criteria must be applied with caution [11, 63, 64]:

  • It is necessary to examine the entire published literature; it is not acceptable to pick out only those reports that support the existence of a health hazard.
  • It is necessary to directly review the important source documents; it is not acceptable to base judgments solely on academic or regulatory reviews.
  • Satisfying the individual criteria is not a yes-no matter; support for a criterion can be strong, moderate, weak, or non-existent.
  • The criteria must be viewed as a whole; no individual criterion is either necessary or sufficient for concluding that there is a causal relationship between exposure to an agent and a disease.

10) How strong is the epidemiological evidence for a causal association between static fields and cancer?

Application of the Hill criteria (see Q9) shows that the current epidemiological evidence for a connection between static magnetic fields and cancer is weak to non-existent.

  1. There is only a weak association between static magnetic fields and cancer. There is only one study that shows any indication of an association of static fields with cancer [8], and that association is not large, and is seen for only one type of cancer.
  2. The association between static magnetic fields and cancer is not consistent. The studies of workers exposed to static magnetic fields in industries other than aluminum reduction plants [6, 7] show no association between exposure to static fields and cancer; and all but one of the studies in the aluminum industry show no association between exposure to static magnetic fields and cancer.
  3. Since only one study reports an association between exposure to static fields and cancer, the issue of specificity is moot.
  4. There is no evidence for a dose-response relationship between exposure to static fields and the incidence of cancer. The only study reporting an association between exposure to static fields and cancer shows no evidence of a dose-response relationship.

Thus the epidemiological evidence for an association between static magnetic fields and cancer is weak and inconsistent, and fails to show a dose-response relationship.

In a 2004 review of the epidemiological studies of occupation exposure to static magnetic fields Feychting [133] concluded:

"There are only a few epidemiological studies available [about static magnetic field exposure and long-term health effects], and the majority of these have focused on cancer risks... Overall, few occupational studies have focused specifically on effects of static magnetic field exposure, and exposure assessment have consequently been poor or non-existent. Results from studies that have estimated static magnetic field exposure have not indicated any increased cancer risks, but they are generally based on small numbers of cases and crude exposure assessment. Control of confounding has been limited, and it is likely that the "healthy worker" effect have influenced the results... A problem in epidemiological studies of static magnetic fields is that workers in exposed occupations are also exposed to a wide variety of other potentially harmful agents, including some known carcinogens. In conclusion, the available evidence from epidemiological studies is not sufficient to draw any conclusions about potential health effects of static magnetic field exposure."

11) How could laboratory studies be used to help evaluate the possible relationship between static magnetic fields and cancer?

When epidemiological evidence for a causal relationship is weak to non-existent, as in the case of static magnetic fields and cancer, laboratory studies would have to provide strong evidence for carcinogenicity in order to tip the balance.

Carcinogens, agents that cause cancer, can be either genotoxic or epigenetic (in older terminology these were initiators and promoters). Genotoxic agents (genotoxins) can directly damage the genetic material of cells. Genotoxins often affect many types of cells, and may cause more than one kind of cancer. Genotoxins may not have thresholds for their effect; so as the dose of the genotoxin is lowered the risk gets smaller, but it may never go away. Thus evidence for genotoxicity at any field intensity would be relevant to assessing carcinogenic potential [62, 75].

An epigenetic agent is something that increases the probability that a genotoxin will damage the genetic material of cells or that a genotoxin will cause cancer. Promoters are a particular kind of epigenetic agent that increase the cancer risk in animals already exposed to a genotoxic carcinogen. Epigenetic agents (including promoters) may affect only certain types of cancer. Epigenetic agents generally have thresholds for their effect; so as the dose of an epigenetic agent is lowered a level is reached at which there is no risk. Thus evidence for epigenetic activity at field intensities far above those actually encountered in residential and occupation settings would not be clearly relevant to assessing carcinogenic potential [62, 75].


12) Are static magnetic fields genotoxic?

A broad range of whole organism and cellular genotoxicity studies of static fields have been carried out. Together these studies offer no consistent evidence that static magnetic fields are genotoxic.

Whole organism genotoxicity studies with static magnetic fields have been rather limited [135]. Beniashvili et al [12] found no increase in mammary cancer in mice exposed to a 0.02 milliT field. Mahlum et al [13] found that exposure of mice to a 1000 milliT field did not cause mutations, and other investigators found a similar lack of mutagenesis in fruit flies exposed to 1000-3700 milliT fields [14, 15, 16].

There have been two whole organism reports of possible genotoxicity. In 1995, Koana et al [65] found evidence for increased mutations in fruit flies exposed to a 600 milliT field for 24 hours, but only if they were deficient in the ability to repair DNA damage. No effects was seen in fruit flies that had normal DNA repair capacity. In 2001, Suzuki et al [103] reported that exposure of mice to a 3000 or 4700 milliT static field for 24-72 hours caused chromosome damage in their bone marrow cells [103].

Cellular genotoxicity studies have been more extensive. Published laboratory studies have reported that static magnetic fields do not cause any of the effects that indicate genotoxicity. Static magnetic fields do not cause DNA strand breaks [76], chromosome aberrations [18, 19, 20, 21, 22, 23, 79], sister chromatid exchanges [18, 20, 22, 24], cell transformation [19, 25], mutations [26, 27, 28, 94], or micronucleus formation [78, 102].

In 2000 Teichman et al [101] reported that 1500 and 7000 milliT static fields did not cause mutations in bacteria (the Ames assay); and in 2002, Scheriber et al [104] reported a similar absence of mutagenic activity after exposure to a 1599 milliT field. However, in 2003, Zhang et al [117] reported that while a 9000 milliT static field did not cause mutations in normal (wild-type) bacteria or in bacteria that were defective in DNA repair, it did cause mutations in bacteria that were deficient in their ability to handle oxidative stress (that is, bacteria that could not detoxify certain types of reactive free radicals).

In 2004, Potenza et al [123] reported that exposure to a 200-250 milliT static field for several hours altered isolated bacterial DNA, but had no effects on the DNA of whole bacteria.

Some studies of static electrical fields have also been conducted. These have been reviewed by McCann et al [29], who concluded that while there were some reports of genotoxicity for static electrical fields, "all reports of positive results have utilized exposure conditions likely to have been accompanied by auxiliary phenomena such as corona, spark discharge, and transient electrical shocks, whereas negative reports have not."

In a 2004 review of the effects of static magnetic fields on animals, Saunders [135] concluded that:

"Various experimental studies carried out over the last 30-40 years have examined the effects of the chronic or acute exposure of laboratory animals to static magnetic fields... No adverse effects of such fields on the growth and development of tumours have been firmly established. Overall, however, far too few animal studies have been carried out to reach any firm conclusions."

In a 2004 review of the effects of static magnetic fields on cells, Miyakoshi [134] concluded that:

"A further area of interest is whether static magnetic fields cause DNA damage, which can be evaluated by determination of the frequency of micronucleus formation... This method has been used to confirm that a static magnetic field alone has no such effect. However, the frequency of micronucleus formation increases significantly when certain treatments (e.g., X-irradiation) are given prior to exposure to a 10 T [10,000 milliT] static magnetic field. It has also been reported that treatment with trace amounts of ferrous ions in the cell culture medium and exposure to a static magnetic field increases DNA damage, which is detected using the comet assay..."

13) Do static magnetic fields enhance the effects of other genotoxic agents?

Probably not. In general, static magnetic fields do not appear to have this type of epigenetic activity; but here are a few studies that suggest that intense static magnetic fields might enhance the effects of other genotoxic agents.

Three studies [14, 30, 31] found that 140-3700 milliT static fields did not enhance the mutagenic effects of ionizing radiation. Three other studies have reported some evidence hat strong static magnetic fields can enhance genotoxic injury produced by ionizing radiation:

  • Takatsujiet al [32] reported that 1100-1400 milliT static fields caused a slight increase the chromosome injury caused by high doses of ionizing radiation.
  • Norimura et al [33] reported that a 4000 milliT field slightly increased radiation-induced cell killing.
  • Nakahara et al [107] reported that at 10,000 milliT static field enhanced the chromosome injury caused by high doses of ionizing radiation, but that a 1000 milliT static field had no such effect.

Three studies [94, 101, 104] have found that 1500-7200 milliT static fields did not enhance the mutagenic effects of chemical carcinogens.

Repair of radiation-damage was reported not be affected by a 140 milliT field [31], but was inhibited at 4000 milliT [33]. Two studies [34, 78] reported that 1300-4700 milliT static fields did not enhance the mutagenic effects of a known chemical genotoxins, and might even inhibit such activity.

Two studies [35, 36] found that 150-800 milliT static fields did not enhance the development of chemically-induced mammary tumors, but a third study [12] reported that a 0.02 milliT static field did enhance the development of chemically-induced mammary tumors.


14) Do laboratory studies indicate that static magnetic fields have any biological effects that might be relevant to cancer or other human health hazards?

No. Laboratory studies of the effects of static magnetic fields show that these fields do not have any consistent effects on tumor growth, cell growth, immune system function, or hormonal balance.

Tumor growth: In general, static magnetic fields of 13-1150 milliT appear to have no effect on the growth of either chemically-induced [36] or transplanted [37, 38, 39] tumors. However, there is one report that suggests that a 15 milliT static field increases the growth rate of chemically-induced tumors [35].

Cell growth: In general, static magnetic fields of 45-2000 milliT have no effect on the growth of human [20, 33, 39, 67, 97, 113], animal [25, 31, 39, 42, 72, 74, 100, 102, 113] or yeast [66, 125] cells. However, there are some reports of static fields effects on cell growth:

  • Norimura et al, 1993 [33]: inhibition of human lymphocyte growth at 4000-6300 milliT
  • Balyasnikova et al, 1994 [67]: stimulation of mammalian cell growth at 140 milliT
  • McDonald, 1993 [72]: both stimulation and inhibition of DNA synthesis in fibroblasts at 610 milliT
  • Raylman et al, 1996 [76]: inhibition of tumor cell growth at 7000 milliT
  • Aldinucci, 2003 [112]: decreased proliferation of human leukemia cells at 4275 milliT, but no effect on normal lymphocytes
  • Potenza et al, 2004 [123]: increased bacterial cell growth at 300 milliT

Immune system effects: In most studies, static magnetic fields of 13-2000 milliT appear to have no effect on the immune system of animals [38, 40, 41, 42], although one study reports that the implantation of small magnets into the brains of rats enhanced their immune response [43]. Two studies of humans [5, 44] have reported that workers in aluminum reduction plants, where exposure to static magnetic fields is common, have minor alterations in the numbers of some types of immune cells; but these minor changes in cell number are of no known clinical significance, and may not even be related to magnetic field exposure. A study of human white blood cells found no effect of a 4275 milliT field on the inflammatory response of normal or leukemic cells [112]. In 2003, Onodera et al [116] reported that exposure of immune system cells to 10,000 milliT field caused the loss of some cell types if the cells has been stimulated to divide, but no effect if the cells had not been stimulated into division.

Hormonal effects: There are some reports that static magnetic fields of the order of the natural earth field (about 0.05 milliT) can affect melatonin production in rats [45, 46, 47], although other studies with stronger (e.g., 2000 milliT fields [68]) have not seen such effects. The one study with human volunteers showed no effects on melatonin production of overnight exposure to a 2-7 milliT static field [99]. While it has been suggested that melatonin might have "cancer-preventive" activity [48, 49], there is no evidence that static magnetic fields affect melatonin levels in humans, or that melatonin has anti-cancer activity in humans.

A wide range of other possible biological effects have been assessed. Recent reports include:

  • 2002: Teodori et al [111] reported that a 4000 milliT static field had no effect on apoptosis in brain tumor cells, but inhibited apoptosis induced by heat or cytotoxic drugs. They also reported that this field increased intracellular calcium.
  • 2003: Aldinucci et al [112] reported that a 4275 milliT field decreased intracellular calcium levels in human leukemia cells, but not in normal human lymphocytes. Note that this calcium effect is opposite that reported by Teodori et al [111].
  • 2003: Sonnier et al [114] reported that exposure of tumor cells to 0.1-7.5 milliT fields had no effect on the action potential of their cell membranes (this is a measure of membrane function).
  • 2003: Houpt et al [115] reported that exposure of rats to 7000 or 14,000 milliT fields caused behavioral changes after 5-30 minutes, but not after just 1 minute. The same group [118] also found similar behavioral changes in mice exposed to a 14,100 milliT field for 30 minutes.
  • 2003: Rosen [119] reported that exposure of cells to a 125 milliT static field had an effect on the function of their cell membranes.
  • 2003: Madec et al [120] reported that a 1 milliT static field had no effect on intracellular calcium.
  • 2004: Veliks et al [122] reported that 15 minutes of exposure of rats to DC magnets that caused a field of 100 milliT on the surface of their heads caused changes in their heart rate.
  • 2004: Potenza et al [124] reported changes in gene expression in bacteria at 300 milliT.

In a 2004 review of the cellular effects of static magnetic fields, Miyakoshi [134] concluded that:

"Studies have shown that a static magnetic field alone does not have a lethal effect on the basic properties of cell growth and survival under normal culture conditions, regardless of the magnetic density. Most but not all studies have also suggested that a static magnetic field has no effect on changes in cell growth rate [or] cell cycle distribution...Many studies have found a strong magnetic field that can induce orientation phenomena in cell culture."

In a 2004 review of the effects of static magnetic fields on animals, Saunders [135] concluded that:

"Various experimental studies carried out over the last 30-40 years have examined the effects of the chronic or acute exposure of laboratory animals to static magnetic fields... few adverse effects were identified... Generally, the acute responses found during exposure to static fields above about 4 T [4000 milliT] are consistent with those found in volunteer studies, namely the induction of flow potentials around the heart and the development of aversive/avoidance behavior resulting from body movement in such fields. No consistently demonstrable effects of exposure to fields of approximately 1T [1000 milliT] and above have been seen on other behavioral or cardiovascular endpoints... Overall, however, far too few animal studies have been carried out to reach any firm conclusions."

In a 2004 review of the physiological effects of exposure of human to high-field [1500-8000 milliT] MRI units, Chakeres and Vocht [132] concluded:

"There were no clinically significant changes in the subjects' physiologic measurements at 8 T [8000 milliT]. There was a slight increase in the systolic blood pressure with increasing magnetic field strength. There did not appear to be any adverse effect on the cognitive performance of the subjects at 8 T [8000 milliT]. A few subjects commented at the time of initial exposure on dizziness, metallic taste in the mouth, or discomfort related to the measurement instruments or the head coil. There were no adverse comments at 3 months. The 1.5 T [1500 milliT] study had two of the four neuro-behavioral domains exhibiting adverse effects (sensory and cognitive-motor). These studies did not demonstrate any clinically relevant adverse effects on neuro-cognitive testing or vital sign changes. One short-term memory, one sensory, and one cognitive-motor test demonstrated adverse effects, but the significance is not clear."

15) Do static magnetic fields show any reproducible biological effects in laboratory studies?

Yes. While the laboratory evidence does not suggest a link between static magnetic fields and cancer, studies have reported that static magnetic fields do have "bioeffects", particularly at field strengths above 2000 milliT [1, 50, 51, 52, 53, 54, 55]. These "bioeffects" have no obvious connection to cancer.


16) Do static magnetic fields of the intensity encountered in occupational settings show reproducible biological effects?

Possibly. A few biological effects have been reported in laboratory systems for fields as low as 8 milliT [130], and some organisms appear to be able to detect changes in the strength and/or orientation of the Earth's static magnetic field (0.03-0.05 milliT) [1, 54]. In addition, the rates of some chemical reactions can be affected by magnetic fields as low as 1 milliT [56, 57, 71, 98, 129].

In 2004, Ye et al [130] reported that they could affect nerve conduction in crayfish with a field as low as 8 milliT.


17) Are there known mechanisms that would explain how static magnetic fields of the intensity encountered in occupational settings could cause biological effects in humans?

There are known biological mechanisms through which strong (greater than 2000 milliT) static magnetic fields could cause biological effects [1, 50], but these mechanisms could not account for biological effects of static fields with intensities of less than about 200 milliT [1, 50, 136].

Biological effects could be mediated through effects on free radical reaction rates at field strengths as low as 1 milliT [56, 57, 71, 98, 129]; but there is no current evidence that such effects have any significance for human health [71, 77].


18) How does the sum of the laboratory and epidemiological evidence relevant to a connection between static magnetic fields and cancer stand up to the Hill criteria?

Application of the Hill criteria [Q9] shows that the evidence for a causal association between exposure to static fields and the incidence of cancer is weak to nonexistent.

  1. A review of the epidemiological evidence shows a weak to nonexistent association between exposure to static magnetic fields and cancer [Q9].
  2. There is no laboratory evidence that static fields cause the type of effects on cells, tissues or animals that point towards static fields causing, or contributing to, cancer [Q12, Q13, Q14].
  3. From what is known about the biophysics of static magnetic fields and the effects of static magnetic fields on biological systems, the hypothesis that static fields would cause or contribute to cancer has no biophysical plausibility [Q17].

19) Have any independent bodies reviewed the research on static electric and magnetic fields and possible human health effects?

Yes. There have been a number of such reviews of the epidemiological and laboratory literature. None of these reviews have concluded that static magnetic or electrical fields of the intensity encountered in residential and occupational settings are human health hazards.

In 2002, the International Agency for Research on Cancer(IARC) [109] concluded that:

  • "There is inadequate evidence in humans for the carcinogenicity of static electric or magnetic fields..."
  • "No data relevant to the carcinogenicity of static electric or magnetic fields in experimental animals were available."
  • "Static electric and magnetic fields and extremely low-frequency electric fields are not classifiable as to their carcinogenicity to humans."
  • Note that inadequate evidence and not classifiable have special meanings in the IARC classification system. The IARC carcinogen classification system is discussed in detail in Q17F of Powerlines and Cancer FAQs.

A 2004 review by the United Kingdom (British) National Radiological Protection Board (NRPB) [121] concluded that for static electric fields:

"The most plausible and coherent set of data from which guidance can be developed concerns perceptual and annoying responses in static electric fields... Any annoying or other stressful effects should be avoided if exposure is below the threshold for cutaneous perception of around 20 kV/m.... There is insufficient evidence from animal and cellular studies to enable the thresholds for long term effects from chronic exposure to static electric fields to be determined."

For static magnetic fields the NRPB [121] concluded that:

"Studies of workers exposed to strong static magnetic fields of up to several tens of milliT do not overall demonstrate increased health risks... Acute effects on the heart or nervous system associated with flow potential induced during movement in the field should not occur if exposures are below 2 T [2000 milliT]. Particular caution should be applied with exposure to fields in excess of about 5-8 T [5000-8000 milliT]. There is insufficient evidence from animal and cellular studies to enable the thresholds for long term effects from chronic exposure to static magnetic fields to be determined."

A workshop held by the World Health Organization (WHO) in 2004 [131] concluded that:

"...scientific research can provide some measure of confidence that short-term, acute exposures up to about 1-2 T [1000-2000 milliT] should be safe. With regard to patient and volunteer exposure, a few studies report the absence of acute physiological responses at 8 T [8000 milliT] in healthy volunteers, but care must be taken moving in and out of such a field. For occupational exposure, present limits are based on avoiding the sensations of vertigo and nausea induced by such movement. However, it is not possible to determine whether there are any long-term health consequences even from exposure in the [milliT] range because, to date, there are no well-conducted epidemiological studies with sufficient power to be able to come to any conclusion on this, and there are no good long-term animal studies."
"While there are huge benefits to be gained from use of static magnetic fields, particularly in medicine, possible adverse health effects from exposure to them must be properly evaluated so that the true risks and benefits can be assessed. This said, WHO does not want to imply that all use of these fields should be unnecessarily restricted until appropriate research has been conducted and safety assured. An analysis of the interaction mechanisms suggests that short-term health effects can be predicted and so avoided. Further, there is no currently understood mechanism that would appear to lead to any long-term adverse health consequence. However, given the widespread and rapidly expanding use of static magnetic fields, priority should be given to key studies that could give sound scientifically based assurance that these assumptions are correct."

20) Do exposure standards for static electric and magnetic fields exist?

Yes. A number of governmental and professional organizations have developed exposure standards, or have modified or reaffirmed their previous standards. For pacemakers and implanted medical device standards also see Q22.

  • 1994: the American Conference of Governmental Industrial Hygienists (ACGIH) issued a standard for exposure to static magnetic fields [59]. The ACGIH static magnetic field limit is 0.5 milliT for pacemaker users, and for everyone else the time-weighted limit is 60 milliT for whole body exposure and 600 milliT for exposure of the extremities. Because of the nature of ACGIH this standard is applied only to occupational settings.
  • 1994: the International Commission on Non-Ionizing Radiation Protection (ICNIRP) published guidelines for exposure to static magnetic fields [50]. For the general public the magnetic field exposure standard is 40 milliT for continuous exposure, except for persons with cardiac pacemakers and other implanted electronic devices, where the standard is lower (0.5 milliT). For occupational exposure, the standard is 200 milliT for continuous exposure, 2000 milliT for short-term whole-body exposure, and 5000 milliT for exposure to arms and legs.
  • 2004: A draft of new occupational exposure guidelines from the European Union [126] which appear to be nearly identical to the ICNIRP [50] exposure guidelines.

21) What is the basis for the safety standards set by ACGIH, ICNIRP and the European Union?

The standards are based on several considerations.

  • One objective is to keep the electrical currents induced by movement through the static magnetic field to a level less than those that occur naturally in the body.
  • A second objective is to keep the electrical currents induced in large blood vessels by blood flow to a level that will not produce hemodynamic or cardiovascular effects.
  • The pacemaker and prosthetic device restrictions are considered in Q22.

22) Do static fields affect cardiac pacemakers?

Effects on cardiac pacemakers have been reported for fields as low as 1.7 milliT [73]. The most common effect was triggering of the asynchronous mode; the effect is very model and orientation dependent, and in the models tested normal operation resumed when the pacemaker was removed from the field [73]. Some pacemakers also exhibited significant torque when exposed [73]. For this reason current static field guidelines restrict exposures for wearers of cardiac pacemakers to 0.5 milliT [50, 59]. It would be prudent to apply this restriction to other implanted electronic devices, and to prosthetic devices as well, although not all standards are explicit on this point.

In contrast to the above, a 2000 study [96] found that MR imaging could be safely performed at 500 milliT in patients with cardiac pacemakers.

A 2002 study [110] reports that static fields from MRI units can cause unpredictable effects on the reed switches of some pacemakers at field strengths as low as 500 milliT.


23) Do static fields decrease fertility, cause birth defects or increase miscarriage rates?

There is no consistent evidence for such effects.

Fertility: Mur et al [82] found no significant effects on the fertility in men exposed to 4-30 milliT static fields in the aluminum industry; and Evans et al [87] found no effect of fertility in female MRI operators. One animal study reported evidence for decreased male fertility at 1500 milliT [83], but two other studies at 500-700 milliT found no such effect [84, 95]. A fourth animal study reported decreased female fertility at 80 milliT, but not at 30 milliT [93].

Miscarriages: Baker et al [85] found that MRIs done at 1500 milliT in the second and third trimester did not increase the miscarriage rate; and Evans et al [87] found no significant effect on miscarriage rates in female MRI operators. Two animal study reported decreased fetal viability at 30 milliT [86, 93] and 80 milliT [93], but other studies at 500-1000 milliT [90, 95] and 6300 milliT [89] found no such effect.

Birth defects: Baker et al [85] found that MRIs done at 1500 milliT in the second and third trimester did not produce birth defects in humans; and Evans et al [87] found no increase in birth defects in children of female MRI operators. One animal study reported adverse effects on fetal development at 1500 milliT [83]; but other studies found no increase in birth defects at 30 [86], 500-1000 milliT [13, 90, 92, 95] , 4700 milliT [128] or 6300 milliT [89]. Three animal MRI studies done at 1500-4700 milliT [88a, 88b, 127] reported increases in birth defects, but heating due to the radiofrequency (RF) radiation used in MRI cannot be ruled out as a factor. Two other animal MRI studies at 1500-4700 milliT found no increases in birth defects [91, 103].

In a 2004 review of the effects of static magnetic fields on animals, Saunders [135] concluded that:

"Various experimental studies carried out over the last 30-40 years have examined the effects of the chronic or acute exposure of laboratory animals to static magnetic fields... No adverse effects of such fields on reproduction and development... have been firmly established. Overall, however, far too few animal studies have been carried out to reach any firm conclusions."

In a 2004 review of the epidemiological studies of occupation exposure to static magnetic fields Feychting [133] concluded:

"There are only a few epidemiological studies available [about static magnetic field exposure and long-term health effects]... There are some reports on reproductive outcomes... Overall, few occupational studies have focused specifically on effects of static magnetic field exposure, and exposure assessment have consequently been poor or non-existent... A few studies have reported results on reproductive outcomes among aluminum workers and MRI operators, but limitations in study designs prevent conclusions... In conclusion, the available evidence from epidemiological studies is not sufficient to draw any conclusions about potential health effects of static magnetic field exposure."

24) Could static field sources (like DC powerlines) cause health effects by creating or attracting ionized particles or chemicals?

There is no consistent evidence for such effects.

Ozone and nitrogen oxides: It has been suggested that ozone and nitrogen oxides created when high voltage lines (AC or DC) arc might be a health hazard. Both compounds could be produced, but there is no evidence that either are produced at levels high enough to be a health hazard. This is discussed in some additional detail in the Q21B of the Powerline FAQ.

Radon and ionized airborne pollutants: Henshaw and Fews [105] have speculated that the radioactive decay products of radon, and other potentially-carcinogenic airborne particles, might be attracted to strong electric field sources, and that there could be enhanced exposure to such carcinogenic agents near high-voltage power lines. They went on to theorize that this provided a mechanism for an association between AC power lines and childhood leukemia. In 1999, Henshaw and Fews [106] amended their hypothesis to suggest that ions produced by corona from high voltage power lines might attach to aerosol pollutants (for example, motor vehicle exhaust) and increase the probability that these pollutants would be deposited in the lung. They directed their theories to AC sources, but they could also be applied to DC sources. The authors have so far presented no evidence that this increased pollutant exposure actually occurs.

The basic observation of increased deposition of radon daughter aerosols on very strong electric (not magnetic) field sources is plausible. However, there are major theoretical problems with the Henshaw/Fews hypotheses which indicate that the postulated mechanisms are extremely unlikely to produce adverse human health effects under real-world exposure conditions. The problems with the theory are is discussed in considerable detail in the Q32 of the Powerline FAQ.


Bibliography

1) CI Kowalczuk et al: Biological Effects of Exposure to Non-ionizing Electromagnetic Fields and Radiation. I. Static Electric and Magnetic Fields (NRPB-R238). Natl Radiat Protec Board, Chilton, (1991).

2) MA Stuchly: Human exposure to static and time-varying magnetic fields. Health Phys 51:215-225 (1986).

3) NIOSH Health Hazard Evaluation Report: Alumax of South Carolina. Cent Disease Control Prevention, NIOSH, (1994).

4) R VonKaenel et al: The determination of the exposure to electromagnetic fields in aluminum electrolysis. In: "Light Metals 1994", U Mannweiler., ed., The Minerals, Metals and Materials Society, pp. 253-260 (1994).

5) JL Marsh et al: Health effect of occupational exposure to steady magnetic fields. Amer Indust Hygiene Assoc J 43:387-394 (1982).

6) L Barregard et al: Cancer among workers exposed to strong static magnetic fields (letter). Lancet October 19, 1985:892 (1985).

7) TF Budinger et al: Biological effects of static magnetic fields. In: "Proc 3rd Annual Soc Magnet Reson Med", Berkeley, pp. 113-114 (1984).

8) S Milham: Mortality in aluminum reduction plant workers. J Occup Med 21:475-480 (1979).

9) HE Rockette and VC Arena: Mortality studies of aluminum reduction plant workers: Potroom and carbon department. J Occup Med 25:549-557 (1983).

10) JM Mur et al: Mortality of aluminum reduction plant workers in France. Int J Epidem 18:257-264 (1987).

11) AB Hill: The environment and disease: Association or causation? Proc Royal Soc Med 58:295-300 (1965).

12) DS Beniashvili et al: Low-frequency electromagnetic radiation enhances the induction of rat mammary tumors by nitrosomethyl urea. Cancer Let 61:75-79 (1991).

13) DD Mahlum et al: Dominant lethal studies in mice exposed to direct-current magnetic fields. In: "Biological effects of extremely low frequency electromagnetic fields". RD Phillips et al., eds., Battelle Pacific Northwest Laboratory, Richland, WA, pp. 474-484 (1979).

14) S Mittler: Failure of magnetism to influence production of X-ray induced sex-linked recessive lethals. Mutat Res 13:287-288 (1971).

15) JR Diebolt: The influence of electrostatic and magnetic fields on mutation in Drosophila melanogaster spermatozoa. Mutat Res 57:169-174 (1978).

16) PG Kale and JW Baum: Genetic effects of strong magnetic fields in Drosophila melanogaster, I. Homogeneous fields ranging from 13,000 to 37,000 Gauss. Mutat Res 1:371-374 (1979).

18) P Cooke and PG Morris: The effects of NMR exposure on living organisms. II. A genetic study of human lymphocytes. Br J Radiol 54:622-625 (1981).

19) CR Geard et al: Magnetic resonance and ionizing radiation: A comparative evaluation in vitro of oncogenic and genotoxic potential. Radiology 152:199-202 (1984).

20) FJ Peteiro-Cartelle and J Cabezas-Cerrato: Absence of kinetic and cytogenetic effects on human lymphocytes exposed to static magnetic fields. J Bioelec 8:11-19 (1989).

21) VV Shevchenko et al: [On the problem of induction of chromosome aberrations in plants by a constant magnetic field]. Genetika 14:1101-1103 (1978).

22) S Wolff et al: Magnetic resonance imaging: Absence of in vitro cytogenetic damage. Radiology 155:163-165 (1985).

23) S Wolff et al: Tests for DNA and chromosomal damage induced by nuclear magnetic resonance imaging. Radiology 136:707-710 (1980).

24) E Yamazaki et al: Effect of Gd-DTPA and/or magnetic field and radiofrequency exposure on sister chromatid exchange in human peripheral lymphocytes. Acta Radiol 34:607-611 (1993).

25) ME Frazier et al: In vitro evaluations of static magnetic fields. In: "Biological effects of extremely low frequency electromagnetic fields", RD Phillips et al., eds., Technical Information Center, US Department of Energy, Springfield, pp. 417-435 (1979).

26) RL Moore: Biological effects of magnetic fields: studies with microorganisms. Can J Microbiol 25:1145-1151 (1979).

27) JL Schwartz and LE Crooks: NMR imaging produces no observable mutations or cytotoxicity in mammalian cells. Amer J Roent 139:583-585 (1982).

28) A Thomas and PG Morris: The effects of NMR exposure on living organisms. I. A microbial assay. Br J Radiol 54:615-621 (1981).

29) J McCann et al: The genotoxic potential of electric and magnetic fields: an update. Mutat Res 411:45-86, 1998.

30) PG Kale and JW Baum: Genetic effects of strong magnetic fields in Drosophila melanogaster, II. Lack of interaction between homogeneous fields and fission neutron-plus-gamma radiation. Environ Mutagen 2:179-186 (1980).

31) S Rockwell: Influence of a 1400-gauss magnetic fields on the radiosensitivity and recovery of EMT6 cells in vitro. Int J Rad Biol 31:153-160 (1977).

32) T Takatsujiet al: Effect of static magnetic fields on the induction of chromosome aberrations by 4.9 MeV protons and 23 MeV alpha particles. J Rad Res 30:238-246 (1989).

33) T Norimura et al: Effects of strong magnetic fields on cell growth and radiation response of human T-lymphocytes in culture. Sangyo Ika Diagaku Zasshi 15:103-112 (1993).

34) PG Kale and JW Baum: Genetic effects of strong magnetic fields in Drosophila melanogaster. III. Combined treatment with homogeneous fields and gaseous DBCP. Mutat Res 105:79-83 (1982).

35) M Mevissen et al: Effects of magnetic fields on mammary tumor development induced by 7,12-dimethylbenz(a)anthracene in rats. Bioelectromag 14:131-143 (1993).

36) A Bellossi: The effect of a static uniform magnetic field on mice a study of methylcholanthrene carcinogenesis. Rad Environ Biophys 23:107-109 (1984).

37) A Bellossi: The effect of a static non-uniform magnetic field on mice a study of Lewis tumour graft. Rad Environ Biophys 25:231-234 (1986).

38) A Bellossi and L Toujas: The effect of a static uniform magnetic field on mice: A study of a Lewis tumor graft. Rad Environ Biophys 20:153-157 (1982).

39) S Chandra and S Stefani: Effect of constant and alternating magnetic fields on tumor cells in vivo and in vitro. In: "Biological Effects of Extremely Low Frequency Electromagnetic Fields, Proceedings of the 18th Hanford Life Symposium ", RD Phillips et al., eds., Technical Information Center, U. S. DoE, Springfield, pp. 436-446 (1979).

40) JH Battocletti et al: Exposure of rhesus monkeys to 20,000 G steady magnetic field: Effect on blood parameters. Med Phys 8:115-118 (1981).

41) M Osbakken et al: A gross morphologic, histologic, hematologic, and blood chemistry study of adult and neonatal mice chronically exposed to high magnetic fields. Magnet Reson Med 3:502-517 (1986).

42) TS Tenforde and M Shifrine: Assessment of the immune responsiveness of mice exposed to a 1.5-Tesla stationary magnetic field. Bioelectromag 5:443-446 (1984).

43) BD Jankovic et al: Potentiation of immune responsiveness in aging by static magnetic fields applied to the brain. Role of the pineal gland. Ann NY Acad Sc. 719:410-418 (1994).

44) RL Davis and S Milham: Altered immune status in aluminum reduction plant workers. Amer J Indust Med 18:79-85 (1990).

45) A Lerchl et al: Marked rapid alterations in nocturnal pineal seratonin metabolism in mice and rats exposed to weak intermittent magnetic fields. Biochem Biophys Res Commun 169:102-108 (1990).

46) K Yaga et al: Pineal sensitivity to pulsed static magnetic fields changes during the photoperiod. Brain Res Bul 30:153-156 (1993).

47) J Olcese et al: Evidence for the involvement of the visual system in mediating magnetic field effects on pineal melatonin synthesis in the rat. Brain Res 333:382-384 (1985).

48) RJ Reiter and BA Richardson: Magnetic field effects on pineal indoleamine metabolism and possible biological consequences. FASEB J. 6:2283-2287 (1992).

49) RJ Reiter: Electromagnetic fields and melatonin production. Biomed Pharmacother 47:439-444 (1993).

50) MH Repacholi et al: Guidelines on limits of exposure to static magnetic fields. Health Phys 66:100-106 (1994).

51) E Kanal et al: Safety considerations in MR imaging. Radiology 176:593-606 (1990).

52) International Non-Ionizing Radiation Committee: Protection of the patient undergoing a magnetic resonance examination. Health Phys 61:923-928 (1991).

53) JF Schenck: Health and physiological effects of human exposure to whole-body four-Tesla magnetic fields during MRI. Ann. NY Acad Sci 649:285-301 (1992).

54) G Miller: Exposure guidelines for magnetic fields. Amer Indust Hygiene Assoc J 48:957-968 (1987).

55) FS Prato et al: Blood-brain barrier permeability in rats is altered by exposure to magnetic fields associated with magnetic resonance imaging at 1.5 T. Micro Res. Tech 27:528-534 (1994).

56) K Schulten: Magnetic field effects in chemistry and biology. Adv Solid State Phys 22:61-83 (1982).

57) JC Scaiano et al: Model for the rationalization of magnetic field effects in vivo. Application of the radical-pair mechanism to biological systems, Photochem Photobiol 59:585-589 (1994).

59) Documentation of Threshold Limit Values, American Conference of Government Industrial Hygienists, Cincinnati, OH, (1994).

61) A Ronneberg and A Andersen: Mortality and cancer morbidity in workers from an aluminum smelter with prebaked carbon anodes -- part II: cancer morbidity. Occup Environ Med 52:250-254, 1995.

62) JE Moulder and KR Foster: Biological effects of power-frequency fields as they relate to carcinogenesis. Proc Soc Exp Biol Med 209:309-324, 1995.

63) G Taubes: Epidemiology faces its limits. Science 269:164-169, 1995.

64) JJ Schlesselman: "Proof" of cause and effect in epidemiologic studies: Criteria for judgment. Prev Med 16:195-210, 1987.

65) T Koana et al: Estimation of genetic effects of a static magnetic field by a somatic cell test using mutagen-sensitive mutants of Drosophila melanogaster. Bioelectrochem Bioenerg 36:95-100, 1995.

66) JA Malko et al: Search for influence of 1.5 Tesla magnetic field on growth of yeast cells. Bioelectromag 15:495-501, 1994.

67) IV Balyasnikova et al: Effect of a static magnetic field on the growth rate and in vitro angiogenesis of endothelial cells. Bul Exper Biol Med 117:110-113, 1994.

68) RL Levine et al: Magnetic field effects on spatial discrimination and melatonin levels in mice. Physiol Behav 58:535-537, 1995.

71) B Brocklehurst and KA McLauchlan: Free radical mechanism for the effects of environmental electromagnetic fields on biological systems. Int J Rad Biol 69:3-24, 1996.

72) F McDonald: Effect of static magnetic fields on osteoblasts and fibroblasts in vitro. Bioelectromag 14:187-196, 1993.

73) W Pavlicek et al: The effects of nuclear magnetic resonance on patients with cardiac pacemakers. Radiology 147:149-153, 1983.

74) B Kula and M Drozdz: A study of magnetic field effects on fibroblast cultures: The evaluation of the effects of static and extremely low frequency (ELF) magnetic fields on vital functions of fibroblasts. Bioelectrochem Bioenerg 39:21-26, 1996.

75) R Kavet: EMF and current cancer concepts. Bioelectromag 17:339-357, 1996.

76) RR Raylman et al: Exposure to strong static magnetic field slows the growth of human cancer cells in vitro. Bioelectromag 17:358-363, 1996.

77) N Mohtat et al: Magnetic field effects on the behavior of radicals in protein and DNA environments. Photochem Photobiol 67:111-118, 1998.

78) H Okonogi et al: The effects of a 4.7 tesla static magnetic field on the frequency of micronucleated cells induced by mitomycin C. Tohoku J Exp Med 180:209-215, 1996.

79) BI Rapley et al: Influence of extremely low frequency magnetic fields on chromosomes and the mitotic cycle in Vicia faba L, the broad bean. Bioelectromag 19:152-161, 1998.

80) P Chadwick et al: Magnetic fields on British trains. Ann Occup Hyg 5:331-335, 1998.

82) JM Mur et al: Demographic evaluation of the fertility of aluminum industry workers: influence of exposure to heat and static magnetic fields. Human Repro 13:2016-2019, 1998.

83) VR Narra et al: Effects of a 1.5-Tesla static magnetic field on spermatogenesis and embryogenesis in mice. Invest Radiol 31:586-590, 1996.

84) L Tablado et al: Is sperm motility maturation affected by static magnetic fields? Environ Health Perspect 104:1212-1216, 1996.

85) PN Baker et al: A three-year follow-up of children imaged in utero with echo-planar magnetic resonance imaging. Amer J Obstet Gynecol 170:32-33, 1994.

86) M Mevissen et al: Effects of static and time-varying (50-Hz) magnetic fields and reproduction and fetal development in rats. Teratology 50:229-237, 1994.

87) JA Evans et al: Infertility and pregnancy outcome among magnetic resonance imaging workers. J Occup Med 35:1191-1195, 1993.

88a) DA Tyndall: MRI effects on craniofacial size and crown-rump length in C57BL/6J mice in 1.5T fields. Oral Surg Oral Med Oral Pathol 76:655-660, 1993.

88b) DA Tyndall et al: Effects of magnetic resonance imaging on eye development in the C57BL/6J mouse. Teratology 43:263-275, 1991.

89) J Murakami et al: Fetal development of mice following intrauterine exposure to a static magnetic field of 6.3 T. Magn Reson Imaging 10:433-437, 1992.

90) G Konermann et al: Untersuchungen über den einfluss staticher magnetfelder uaf die pränatale entwicklung der maus [Studies of the influence of a static magnetic field on prenatal development in mice]. Radiologe 26:490-497, 1986.

91) D McRobbie et al: Pulsed magnetic field exposure during pregnancy and implications for NMR foetal imaging: a study with mice. Magn Reson Imaging 3:231-234, 1985.

92) MR Sikov et al: Development of mice after intrauterine exposure to direct-current magnetic fields, In: "Biological effects of extremely low frequency electromagnetic fields", RD Phillips et al., eds., Battelle Pacific Northwest Laboratory, Richland, WA, pp. 462-473 (1979).

93) M Nakagawa: Effects of magnetic fields on fertility, general reproductive performance and growth of mice. Nippon Eiseigaku Zasshi 34:488-495 (1979).

94) M Ikehata, T Koana et al: Mutagenicity and co-mutagenicity of static magnetic fields detected by bacterial mutation assay. Mutat Res 427:147-156 (1999).

95) L Tablado, C Soler et al: Development of mouse testis and epididymis following intrauterine exposure to a static magnetic field. Bioelectromag 21:19-24 (2000).

96) T Sommer, C Vahlhaus et al: MR imaging and cardiac pacemakers: In vitro evaluation and in vivo studies in 51 patients at 0.5 T. Radiology 215:869-879 (2000).

97) J Wiskirchen, EF Grönewäller et al: Human fetal lung fibroblasts: In vitro study of repetitive magnetic field exposure to 0.2, 1.0, and 1.5 T. Radiology 215:858-862 (2000).

98) RW Eveson, CR Timmel et al: The effects of weak magnetic fields on radical recombination reactions in micelles. Int J Radiat Biol 76:1509-1522 (2000).

99) B Haugsdal, T Tynes et al: A single nocturnal exposure to 2-7 millitesla static magnetic fields does not inhibit the excretion of 6-sulfatoxymelatonin in healthy young men. Bioelectromag 22:1-6 (2001).

100) H Sakurai, K Okuno et al: Effect of a 7-tesla homogeneous magnetic field on mammalian cells. Bioelectrochem Bioenerg 49:57-63 (1999).

101) EM Teichmann, JG Hengstler et al: Untersuchung eines möglichem mutagenen potenzials van magnetfeldren [Possible mutagenic effects of magnetic fields]. Fortschr Röntgenstr 172:934-939, 2000.

102) Y Suzuki, M Ikehata et al: Induction of micronuclei in mice exposed to static magnetic fields. Mutagenesis 16:499-501, 2001.

103) R Okazaki, A Ootsuyama et al: Effects of a 4.7 T static magnetic field on fetal development in ICR mice. J Radiat Res 42:273-283, 2001.

104) WG Schreiber, EM Teichmann et al: Lack of mutagenic and co-mutagenic effects of magnetic fields during magnetic resonance imaging. J Mag Res Imaging 14:779-788, 2001.

105) AP Fews, DL Henshaw et al: Increased exposure to pollutant aerosols under high voltage power lines. Int J Radiat Biol 75:1505-1521, 1999.

106) AP Fews, DL Henshaw et al: Corona ions from powerlines and increased exposure to pollutant aerosols. Int J Radiat Biol 75:1523-1531, 1999.

107) T Nakahara, H Yaguchi et al: Effects of exposure of CHO-K1 cells to a 10-T static magnetic field. Radiology 224:817-822, 2002.

109) International Agency for Research on Cancer(IARC): Static and extremely low-frequency (ELF) electric and magnetic fields. Report No. 80, 2002.

110) R Luechinger, F Duru et al: Pacemaker reed switch behavior in 0.5, 1.5, and 3.0 tesla magnetic resonance imaging units: Are reed switches always closed in strong magnetic fields? J Pag Clin Electrophys 25:1419-1423, 2002.

111) L Teodori, W Göhde et al: Static magnetic fields affect calcium fluxes and inhibit stress-induced apoptosis in human glioblastoma cells. Cytometry 49:143-149, 2002.

112) C Aldinucci, JB Garcia et al: The effect of strong static magnetic field on lymphocytes. Bioelectromag 24:109-117, 2003.

113) IB Schiffer, WG Schreiber et al: No influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRI. Bioelectromag 24:241-250, 2003.

114) H Sonnier, O Kolomytkin et al: Action potentials from human neuroblastoma cells in magnetic fields. Neurosci Let 337:163-166, 2003.

115) TA Houpt, DW Pittman et al: Behavioral effects of high-strength static magnetic fields on rats. J Neurosci 23:1498-1505, 2003.

116) H Onodera, S Chidaet al: Effects of 10-T static magnetic field on human peripheral blood immune cells. Radiat Res 159:775-779, 2003.

117) QM Zhang, M Tokiwa et al: Strong static magnetic field and the induction of mutations through elevated production of reactive oxygen species in Escherichia coli soxR. Int J Rad Biol 79:281-286, 2003.

118) DR Lockwood, B Kwon et al; Behavioral effects of static high magnetic fields on unrestrained and restrained mice. Physiol Behavior 78:635-640, 2003.

119) AD Rosen: Effect of a 125 milliT static magnetic field on the kinetics of voltage activated Na+ channels in GH3 cells. Bioelectromagnetics 24:517-523, 2003.

120) F Madec, B Billaudel et al: Effects of ELF and static magnetic fields on calcium oscillations in islets of Langerhans. Bioelectrochem 60:73-80, 2003.

121) AF McKinlay, SG Allen et al: Review of the scientific evidence for limiting exposure to electromagnetic fields (0-300 GHz). Doc NRPB 15:1-215, 2004.
On-line at: www.nrpb.org/publications/documents_of_nrpb/abstracts/absd15-3.htm

122) V Veliks, E Ceihnere et al: Static magnetic field influence on rat brain function detected by heart rate monitoring. Bioelectromag 25:211-215, 2004.

123) L Potenza, L Cucchiarini et al: Effects of high static magnetic field exposure on different DNAs. Bioelectromag 25:352-355, 2004.

124) L Potenza, L Ubaldi et al: Effects of a static magnetic field on cell growth and gene expression in Escherichia coli. Mut Res 561:53-62, 2004.

125) MJ Ruiz-Gomez, MI Prieto-Barcia et al: Static and 50 Hz magnetic fields of 0.35 and 2.45 mT have no effect on the growth of Saccharomyces cerevisiae. Bioelectrochem 64:151-155, 2004.

126) Directive 2004/40/EC of the European Parliament and of the Council of 29 April 2004 on the minimum health and safety requirements regarding the exposure of workers to the risks arising from physical agents (electromagnetic fields). Official J Europ Union L159:1-26, 2004.

127) KI Carnes and RL Magin: Effects of in utero exposure to 4.7 T MR imaging conditions on fetal growth and testicular development in the mouse. Magnet Res Imag 14:263-274, 1996.

128) WB High, J Sikora et al: Subchronic in vivo effects of a high static magnetic field (9.4 T) in rats. J Magnet Res Imag 12:122-139, 2000.

129) CB Vink and JR Woodward: Effect of a weak magnetic field on the reaction between neutral free radicals in isotropic solution. J Amer Chem Soc 126:16730-16731, 2004.

130) SR Ye, JW Yang et al: Effect of static magnetic fields on the amplitude of action potential in the lateral giant neuron of crayfish. Int J Rad Biol 80:699-708, 2004.

131) AF McKinlay and MH Repacholi: More research is needed to determine the safety of static magnetic fields. Prog Biophys Molec Biol 87:173-174, 2005.

132) DW Chakeres and F de Vocht: Static magnetic field effects on human subjects related to magnetic resonance imaging systems. Prog Biophys Molec Biol 87:255-265, 2005.

133) M Feychting: Health effects of static magnetic fields--a review of the epidemiological evidence. Prog Biophys Molec Biol 87:241-246, 2005.

134) J Miyakoshi: Effects of static magnetic fields at the cellular level. Prog Biophys Molec Biol 87:213-223, 2005.

135) R Saunders: Static magnetic fields: animal studies. Prog Biophys Molec Biol 87:225-239, 2005.

136) JF Schenck: Physical interactions of static magnetic fields with living tissues. Prog Biophys Molec Biol 87:185-204, 2005.


Notice:

This FAQ is Copyright©, 1996-2012, by John Moulder, Ph.D. and the Medical College of Wisconsin, and is made available as a service to the Internet community. Portions of this FAQ were derived from the following four articles, and are covered by the Copyrights on those articles:

  • JE Moulder and KR Foster: Biological effects of power-frequency fields as they relate to carcinogenesis. Proc Soc Exp Med Biol 209:309-324, 1995.
  • JE Moulder: Biological studies of power-frequency fields and carcinogenesis. IEEE Eng Med Biol 15 (Jul/Aug):31-49, 1996.
  • KR Foster, LS Erdreich, JE Moulder: Weak electromagnetic fields and cancer in the context of risk assessment. Proc IEEE 85:733-746,1997.
  • JE Moulder: Power-frequency fields and cancer. Crit Rev Biomed Engineering 26:1-116, 1998.

Permission is granted to copy and redistribute this document electronically or in printed form as long as it is unmodified. This FAQ may not be sold in any medium, including electronic, CD-ROM, or database, or published in print, without the explicit, written permission of John Moulder.


GO TO: Table of Contents | Bibliography | HOME


 

webmaster@mcw.edu
© 2014 Medical College of Wisconsin
Page Updated 05/28/2014