Dr. Amanda L. Kong is the primary investigator for a new randomized controlled trial that will determine the optimal way of managing post-operative pain in breast cancer patients undergoing a mastectomy with or without reconstruction. The study is a collaborative effort between the Departments of Surgery, Anesthesia, and Plastic and Reconstructive Surgery at Froedtert and The Medical College of Wisconsin. Patients will be eligible for the study if they are undergoing a mastectomy with or without a tissue expander. Those patients undergoing a sentinel node biopsy or axillary dissection in conjunction with their mastectomy are eligible as well. The study will accrue approximately 150 patients who will be randomly assigned to one of three groups. One group will receive a single dose of anesthetic into the paravertebral space next to the spine, another group will receive pain medication continuously through a catheter located in this space, and the third group will receive pain medication directly in a continuous manner into their wound. The patients will be followed post-operatively to see how well their pain is controlled and how satisfied they are with their post-operative pain management. For patients or physicians who are interested or have any questions regarding the study, Dr. Kong may be contacted at 414-805-5815.