Interdisciplinary Program Faculty
EPR spectroscopy to determine the ligation of metals in (primarily, copper) proteins and complex biological systems
Cardiovascular and Radiation Effects
Transcriptional control of liver and gut development and physiology
General cardiology, inheritable cardiac failure and myocardial infarction
Cellular and molecular basis of circadian rhythmicity in peripheral oscillators; molecular/cellular basis of trafficking...
The genetics of bone biomechanical performance and of vertebral development
Breast Cancer Research, Imaging Studies
Regulation of vascular tone and adrenal steroidogenesis by endothelial factors
High-resolution retinal imaging & structure-function relationships in the human retina
Immunogenetics of Type 1 Diabetes
Cell and Cardiovascular Biology
Molecular mechanisms underlying liver development and function, with a particular focus on the role played chromatin...
Diabetes, beta-cell biology, inflammation innate immunity, cell signaling, cell fate decisions
Effector and memory T cell differentiation
Glycobiology, lysosome biogenesis, lysosomal storage disorders, regulation of growth factor and protease activation
Immune regulation and homeostasis
Immunobiology of bone marrow transplantation
Cancer Metastasis, Tumor Microenvironment, Mucosal Inflammation
Neurodegenerative diseases, both understanding the molecular basis for the disease progression and finding...
The physical health effects of sleep deprivation with a focus on neuroendocrine and immune systems
Deciphering the cellular mechanisms and proteins regulating normal and abnormal blood platelet production and function
Biological and biochemical characterization of antimicrobial peptides, EPR site-directed spin labeling...
Genetic regulation of exotoxin synthesis
Mechanistic study of gene transcription and its regulation in eukaryotic cells using structural and biochemical methods
Cellular and molecular mechanisms of synaptic plasticity
Elucidation of pro-survival vs. pro-death signaling cascades in tumor cells and other mammalian cells exposed...
Interface of stem cell biology and analytical protein biochemistry to better understand pluripotent stem cells...
Druggability of proteins involved in mitochondrial homeostasis in healthy and diseased cells to identify molecular...
Mechanisms by which nitric oxide affects cellular functions at the level of individual protein modifications
Cardiovascular, Obesity, Diabetes and Hypertension
Transcription within a eukaryotic cell is not process in which RNA polymerase can freely access the DNA for either...
Cancer immunology and immunotherapy
Application of EPR in free radical biology and understanding the role of free radicals...
Structure-function relationships of enzymes and receptors by X-ray crystallography combined with various biochemical methods
Bacterial Signal Transduction, Microbial Communities, Predator-Prey Dynamics, Xenobiotic Disruption of Microbiomes
Site-directed spin labeling EPR spectroscopy technique to study the functional dynamics of bacterial membrane...
Signal transduction and antibiotic resistance in gram-positive bacteria
Genetics and cell biology of ocular development and disease
Gene and cell therapies for ocular and vascular disease
RNA localization in yeast
Cell and molecular biology of early heart development
Molecular mechanisms of integrin activation
NK cell development and function
Understanding the molecular mechanisms governing G protein-coupled receptor signaling
RNA processing (splicing and polyadenylation) in cells and viruses
Gene Therapy for Inherited and Acquired Disorders; Lysosomal Storage Disorders; Cancer
Vasculogenesis and Angiogenesis
Transcriptional control and signaling during epicardial and early coronary vascular development
Prostate Cancer, Jak-Stat signaling
Thrombosis and Hemostasis, Immunology
Neuroscience, Addictive Behavior and Novelty Seeking
We investigate the signaling pathways and metabolic processes that are reprogrammed to facilitate tumorigenesis...
Vascular Disease Research
Blood vessel patterning in vertebrates and its application to human disease
Transcriptional Regulation of Stem Cells
TCR signal transduction and application to tumor immunology
Understanding vibration injury of neural and vascular tissues from hand-held powered tools and the effects of actual...
Cellular responses to M tuberculosis
Understanding HDL functionality, mechanisms that regulate the selective uptake of HDL-cholesterol...
Antimicrobial Peptides, host-microbe interactions in the GI tract, microbiota in health and disease
Elucidation of the neuroprotective mechanisms of ubiquitin and chaperone pathways in neurodegenerative diseases
Discovery of genes underlying complex developmental disorders with an emphasis on developmental glaucoma
Gene and cell therapy of hemophilia A
We study the molecular and cellular pathogenesis of common vascular disorders, including thrombosis...
Epigenetic and redox control of protein function through post-translational modifications
Vascular bed of the placenta and the mechanism of pregnancy-related cardiovascular disorders
Atherosclerosis and HTL in heart disease
Cell signaling as related to pathobiology of kidney diseases
Using induced pluripotent stem cells to study dystrophic cardiomyopathy
Molecules that sense touch and pain
Formation of raft domains in model and biological membranes
Virus-associated Tumorigenesis and Virus-host Interactions
Human cytomegalovirus-host cell protein interactions during infection
Oncology drug development and in the treatment of gastrointestinal cancers.
Elucidation of the role of proteinases and proteinase inhibitors in corneal wound healing...
Superoxide generation from eNOS, regulation of NO production...
Immune regulation, T regulatory cells, role of IL-2 and IL-10 in immune regulation, mechanisms of suppression of immune responses by T regulatory cells
NMR and crystallographic analysis of ligand binding and conformational dynamics in chemokines...
Signal Regulation of B Lymphopoiesis
Immune Regulation Mediated by Negative Checkpoint Regulators and Cancer Immunotherapy
Cancer Genetics and Biomarkers
Coronary collateral growth and impaired angiogenesis in diabetes
T cell development, Regulatory T cell biology, Mucosal tolerance
Cardiovascular and Cancer Research
Molecular mechanisms of a tight coupling between energy metabolism and neuronal activity
Lung Cancer Chemoprevention, Susceptibility Genes, Molecular Pathogenesis of Lung Cancer
Bacterial pathogenesis and host-cell interactions
Transient Receptor Potential (TRP) Channels in Vascular Signaling
Study the mechanism of receptor transmembrane signaling using structural, biochemical, and cell biology methods..
Epigenetic regulation of stem cells and how dysregulation of these pathways contributes to cancer development