The National Biomedical EPR Center at MCW is one of the largest EPR facilities in the nation. It is a national P41 research resource supported by NCRR/NIH. Spectrometers are available for S-, X-, L-, Q- , and W-band EPR, many with ENDOR, ELDOR, saturation transfer, saturation recovery, and multiquantum capabilities. Numerous collaborations and many projects are underway in the EPR Center, including research on
- Free radicals,
- Spin labels,
- Metalloproteins, and
- EPR methodology and instrumentation.
Brain Imaging and Informatics
Scientists in the Department of Biophysics have been engaged in MRI research for more than 20 years, beginning with the installation of one of the first 1.5 Tesla scanners produced by GE Healthcare. Early papers were concerned mostly with the development of surface coils tailored to nearly every body part in the context of musculoskeletal radiology. In 1992, MCW students and faculty published the first paper on fMRI, and available resources became focused on the new field of fMRI. Technology development continued to be important, including the introduction of the local gradient coil for fMRI and development of the widely used fMRI software program AFNI (Analysis of Functional NeuroImages). Currently, emphasis on fMRI technology continues, but, increasingly, MRI research in the Department of Biophysics involves mechanisms of fMRI contrast in the brain and applications of fMRI to problems in neuroscience.
Biophysics MRI researchers work closely with the MRI Safety Committee.