Michael Flinn

Michael_FlinnGraduate Student
Medical College of Wisconsin
Department of Cell Biology, Neurobiology & Anatomy
8701 Watertown Plank Road
Milwaukee, WI 53226-3548

(414) 955-8509
(414) 955-6517 (fax)

BS, Northern Illinois University, 2009
MS, Northern Illinois University, 2011

Faculty Advisor: Brian A. Link, PhD

Research Area: Upstream regulatory elements of the Hippo signaling pathway

I graduated from Northern Illinois University in 2009 with a BS in Biological Sciences and again in 2011 with an MS in Biological Sciences. During this time, my research pertained to the translational differences regarding the p3a movement protein of the Brome Mosaic Virus, focusing on translation using either genomic or subgenomic templates.

After attaining my MS, I enrolled into MCW’s interdisciplinary doctoral program and joined the Link lab the following year. Using zebrafish as a model system, the Link lab conducts studies on eye development and disease in a genetic context. The Hippo signaling pathway, discovered initially in Drosophila, is a key pathway involved in organogenesis and disrupted in many forms of cancer. Although a portion of the pathway, known as the “core kinase cassette,” is fairly well understood, the upstream regulatory elements of the cassette are not. The basis of my project revolves around generating genetic knockouts for zebrafish homologs of suspected upstream regulatory elements found in flies, via TALEN or CRISPR mutagenesis, in order to ascertain how the pathway is linked to vertebrate retinal neurogenesis.