Dr. Shi-Jiang Li receives 2017 Alzheimer Award
Aug. 22, 2017 MCW News - Shi-Jiang Li, PhD, professor of biophysics, received the 2017 Alzheimer Award from the Journal of Alzheimer’s Disease for his article, “Staging Alzheimer’s Disease Risk by Sequencing Brain Function and Structure, Cerebrospinal Fluid, and Cognition Biomarkers.” Included with the award is a three-inch bronze Alzheimer Medal and a cash prize of $7,500.
The findings presented in this article support the network dysfunction hypothesis of Alzheimer’s disease (AD). The Li lab created an index—the characterizing Alzheimer’s disease risk events, or “CARE,” index—to characterize risks associated with AD stages and quantify disease severity on an individual subject basis. The CARE index will provide a critical window of opportunity to intervene with disease-modifying therapy, and it will facilitate clinical trials by selecting the right segmentation of patient populations based on their disease stages to enrich the response rate and statistical power. It can also be used to monitor and evaluate treatment efficacy through changes in stage status in individual subjects.
Co-authors of the article include Guangyu Chen, PhD, research scientist in biophysics; Hao Shu, MD, PhD, postdoctoral fellow in biophysics; Gang Chen, PhD, research scientist II in biophysics; B. Douglas Ward, MS biostatistician II in biophysics; Piero G. Antuono, MD, professor of neurology; and Zhijun Zhang, PhD, from the Neuropsychiatric Institute and Medical School of Southeast University.