Heart biomagnetism was the first to be evidenced experimentally by (Baule & McFee, 1963) and Russian groups, followed in Chicago, and then in Boston, by David Cohen who contributed significant technological improvements in the late 1960s. The first low-noise MEG recording followed immediately in 1971 when Cohen reported on spontaneous oscillatory brain activity (α-rhythm, [8,12]Hz), just like Hans Berger did with EEG about 40 years before. The seminal technique was revolutionized in 1969 by the introduction of extremely sensitive current detectors developed by James Zimmerman at the Massachusetts Institute of Technology: the superconducting quantum interference devices (SQUIDs).
Once coupled to magnetic pick-up coils, these detectors are able to capture the minute variations of electrical currents induced by the flux of magnetic fields through the coil. Magnetometers – a pick-up coil paired with a current-detector – are therefore the building blocks of MEG sensing technology. Because of the very small scale of the magnetic fields generated by the brain, signal-to-noise (SNR) is a key issue in MEG technology. The superconducting sensing technology involved requires cooling at -269°C (-452F).
About 70 liters of liquid helium are necessary on a weekly basis to keep the system up to performance. Liquid nitrogen is not considered as an alternative because of the relatively higher thermal noise levels it would allow in the circuitry of current detectors. Ancillary refrigeration – e.g., using liquid nitrogen just like in MR systems – is not an option either, for the main reason that MEG sensors need to be located as close to the head as possible. Hence interleaving another container between the helium-cooled sensors and the subject would increase the distance between the sources and the measurement locations, therefore decreasing SNR. Some MEG sites currently experiment solutions to recycle some of the helium that naturally boils off from the MEG gantry. This approach is optimal if gas liquefaction equipment is available in the proximity of the MEG site. Under the best circumstances, this technique allows the recuperation and re-utilization of about 60% to 90% of the original helium volume.
Thermal insulation is obviously a challenge in terms of safety of the subject, limited boil-off rate and minimal distance to neural sources. The technology involved uses thin sheets of fiberglass separated with vacuum, which brings the pick-up coils only a couple of centimeters away from the head surface, with total comfort to the subject. The MEG instrument therefore consists of a rigid helmet containing the sensors, supplemented by a cryogenic vessel filled with liquid helium. Though the MEG equipment is obviously not ambulatory, most commercial systems can operate with subjects in seated (upright) and horizontal (supine) positions. Having these options is usually well-appreciated by investigators in terms of alternatives for stimulus presentation, subject comfort, etc.
Typical MEG and EEG equipment. Top left: An elastic EEG cap with 60 electrodes. Top right: An MEG system, which can be operated both in seated upright (bottom left) and supine horizontal (bottom right) positions. EEG recordings can be performed concurrently with the MEG’s, using magnetically-compatible electrodes and wires. (Illustrations adapted courtesy of Elekta.)
Froedtert & The Medical College of Wisconsin MEG Contact Information
Research investigators and clinical physicians are encouraged to contact us for further information on how to access our MEG Program and services.
Jeffrey Stout, PhD: Technical Manager
Send an email | (414) 805-1174 | (414) 805-1103 (fax)
Jean Roccapalumba, CTRS, MBA: Program Manager
Send an email | (414) 805-9906 | (414) 259-1159 (fax)
Department of Neurology
Medical College of Wisconsin
9200 W. Wisconsin Avenue
Milwaukee, WI 53226
MEG Program Site Map
If you are a physician and would like to inquire about or order a MEG study for your patients, please visit Froedtert Hospital MEG web pages for basic information about the procedure and/or contact Linda Allen, RN BSN, our Epilepsy Program Coordinator at (414) 805-3641 to refer your patient to our Program.
If you are a patient who is about to undergo an MEG procedure, please also visit Froedtert Hospital MEG web pages for useful information regarding the MEG routine.