Studying the selective toxicity of small molecule inhibitors for removal of remnant pluripotent stem cells from differentiation cultures
Studying how the bioenergetics and energy sensing pathways in pluripotent cells are altered with metabolic inhibitors
Advisor: Rebekah Gundry, PhD, Department of Biochemistry
BS, 2010, University of Michigan
PhD, 2016, Medical College of Wisconsin; Department of Biochemistry
National Institutes of Health, 1 year
Advisor: BJ Fowlkes, PhD
Project: My project aimed to determine if GATA3 was a downstream transcription factor regulated by Notch signaling in the TCR signaling pathway during T cell development from double positive thymocytes to C
University of Michigan, 1 year
Advisor: Randall Kaufman, PhD
Project: I contributed to a project studying the effects of C/EBP Homologous Protein (CHOP) protein in the development of Non-Alcoholic Fatty Liver Disease (NAFLD).
Boheler KR, Bhattacharya S, Kropp EM, Chuppa S, Riordon DR, Burridge PW, Wu JC, Wersto RP, Rao S, Wollscheid B, Gundry RL, A Human Pluripotent Stem Cell Surface N-Glycoproteome Resource Reveals New Markers, Extracellular Epitopes, and Drug Targets. Stem Cell Reports, 2014, 3(1):185-203. PMC 4110789
Bhattacharya S, Burridge PW, Kropp EM, Chuppa S, Kwok WM, Wu JC, Boheler KR, Gundry RL, High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry, Journal of Visualized Experiments, 2014, 91, 52010. PMID: 25286293.
Kropp EM, Bhattacharya S, Waas M, Chuppa SL, Hadjantonakis AK, Boheler KR, Gundry RL, N-Glycoprotein Surfaceomes of Four Developmentally Distinct Mouse Cell Types, Proteomics – Clinical Applications, 2014, 8(7-8): 603-9. PMC4151168.
Kropp EM, Oleson BJ, Broniowska KA, Bhattacharya S, Chadwick AC, Diers, AR, Hu Q, Sahoo D, Hogg N, Boheler KR. Corbett JA, Gundry, RL. Inhibition of an NAD+ Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent Stem Cells, Stem Cells Translational Medicine, 2015 4 (5): 483-93.
Malhi H, Kropp EM, Clavo VF, Kobrossi CR, Han J, Mauer AS, Yong J, Kaufman RJ. C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. J Biol Chem. 2013 Jun 28;288(26):18624-42.
Kropp E.M., Broniowska K.A., Waas M., Corbett J.A., Gundry R.L. A Metabolic Shift with Cardiomyocyte Differentiation Promotes Cell Survival During NAMPT Inhibition. Submitted.
Kropp, E. M., Oleson, B.J., Broniowska, K.A., Bhattacharya, S., Chadwick, A.C., Diers, A.R., Hu, Q., Sahoo, D., Hogg, N., Boheler, K.R., Corbett, J.A., Gundry, R.L. (2015) Inhibition of an NAD+ Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent Stem Cells, Stem Cells TM, 483-493.
Kropp, E. M., Bhattacharya, S., Waas, M., Chuppa, S. L., Hadjantonakis, A. K., Boheler, K. R., and Gundry, R. L. (2014) N-glycoprotein surfaceomes of four developmentally distinct mouse cell types, Proteomics. Clinical applications 8, 603-609.
Bhattacharya, S., Burridge, P. W., Kropp, E. M., Chuppa, S. L., Kwok, W. M., Wu, J. C., Boheler, K. R., and Gundry, R. L. (2014) High efficiency differentiation of human pluripotent stem cells to cardiomyocytes and characterization by flow cytometry, Journal of visualized experiments : JoVE, 52010.
Boheler, K. R., Bhattacharya, S., Kropp, E. M., Chuppa, S., Riordon, D. R., Bausch-Fluck, D., Burridge, P. W., Wu, J. C., Wersto, R. P., Chan, G. C., Rao, S., Wollscheid, B., and Gundry, R. L. (2014) A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets, Stem cell reports 3, 185-203.
Malhi, H., Kropp, E. M., Clavo, V. F., Kobrossi, C. R., Han, J., Mauer, A. S., Yong, J., and Kaufman, R. J. (2013) C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis, The Journal of biological chemistry 288, 18624-18642.
triathlons, cooking, and running