Paytsar TopchyanPaytsar Topchyan

ptopchyan@mcw.edu

Research Interests

Cancer Immunology

Education

BS, 2014, University of California-Los Angeles
Major: Biology; Minor: Armenian Studies

MS, 2016, University of California-Los Angeles
Major: Oral Biology

Research Experiences

University of California-Los Angeles, 2012-2016
Advisor: Dr. Anahid Jewett, PhD, MPH

Publications

Kozlowska, A. K., Topchyan, P., Kaur, K., Tseng, H.-C., Teruel, A., Hiraga, T., & Jewett, A. (2017). Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs. Journal of Cancer, 8(4), 537–554. http://doi.org/10.7150/jca.15989

Kaur, K., Cook, J., Park, S.-H., Topchyan, P., Kozlowska, A., Ohanian, N., … Jewett, A. (2017). Novel Strategy to Expand Super-Charged NK Cells with Significant Potential to Lyse and Differentiate Cancer Stem Cells: Differences in NK Expansion and Function between Healthy and Cancer Patients. Frontiers in Immunology, 8, 297. http://doi.org/10.3389/fimmu.2017.00297

Kozlowska, A. K., Kaur, K., Topchyan, P., & Jewett, A. (2017). Novel strategies to target cancer stem cells by NK cells; studies in humanized mice. Frontiers in bioscience (Landmark edition), 22, 370-384. http://dx.doi.org/10.2741/4489

Kozlowska, A. K., Kaur, K., Topchyan, P., & Jewett, A. (2016). Adoptive transfer of osteoclast-expanded Natural Killer cells for immunotherapy targeting cancer stem-like cells in humanized mice. Cancer Immunology, Immunotherapy : CII, 65(7), 835–845. http://doi.org/10.1007/s00262-016-1822-9

Kozlowska, A. K., Tseng, H. C., Kaur, K., Topchyan, P., Inagaki, A., Bui, V. T., ... & Jewett, A. (2016). Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells. Cancer Immunology, Immunotherapy, 65(9), 1085-1097. 10.1007/s00262-016-1866-x

Tseng, H.-C., Arasteh, A., Kaur, K., Kozlowska, A., Topchyan, P., & Jewett, A. (2015). Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice. Frontiers in Immunology, 6, 259. http://doi.org/10.3389/fimmu.2015.00259

Bui, V. T., Tseng, H.-C., Kozlowska, A., Maung, P. O., Kaur, K., Topchyan, P., & Jewett, A. (2015). Augmented IFN-γ and TNF-α Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release; Regulation by IL-10. Frontiers in Immunology, 6, 576. http://doi.org/10.3389/fimmu.2015.00576

Meeting Abstracts

P. Topchyan, K. Kaur, A. Kozlowska, H. Tseng-Dick, A. Jewett. Super NKs prevent tumor CSC growth in BLT humanized mice. 2016 AADR/CADR Annual Meeting & Exhibition. Los Angeles, CA.

Interests

Reading, cooking, and traveling

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