Jack Gorski, PhD
BloodCenter of Wisconsin
Assistant Professor, Microbiology and Molecular Genetics
Medical College of Wisconsin
Director, Center for Human Immunology
Research Focus: Human Immunology
University of Cincinnati (1976), Developmental Biology
I am interested in understanding the molecular basis of T cell immunity in man, focusing on polymorphism and variability within this system. Work in my lab has involved one to many to one mapping of the principle components of the system: the MHC, antigen peptide, and TCR. We have been interested in the biophysics of binding of multiple peptides to a single class II MHC molecule, as well as the ability of a single peptide to bind multiple class II MHC. Similarly we have a strong interest in the biophysics of many TCR interacting with a single peptide-MHC complex as well as the T cell cross-reactivity (one TCR binding many peptide-MHC complexes). There has been a special emphasis on describing and understanding the long term memory requirements post-thymic involution. This interest has led to molecular analyses of T cell repertoires and the role of cross-reactivity in maintaining immunity as well as providing a selectable population of responders when a new antigen peptide is encountered. Currently we are focusing on possible intrinsic differences in rearrangement of TCR and BCR as evidenced from NGS analysis of circulating and thymic repertoires. Together with Dr. Martin Hessner, we have developed an interest in human plasma/serum as an indicator of overall immune status in an individual.
- Naive T cell repertoire skewing in HLA-A2 individuals by a specialized rearrangement mechanism results in public memory clonotypes. (2011) M. Yassai, D. Bosenko, M. Unruh, G. Zacharias, E. Reed, W. Demos, A. Ferrante and J. Gorski. J Immunol. 186:2970-2967. PMID: 21282510
- The polyclonal CD8 T cell response to influenza M158-66 generates a fully connected network of cross-reactive clonotypes to structurally related peptides: a paradigm for memory repertoire coverage of novel epitopes or escape mutants. (2011) G.V. Petrova, E.N. Naumova, and J. Gorski. J Immunol. 186(11):6390-6397. PMID: 21518969
- Selective T Cell Expansion during Aging of CD8 Memory Repertoires to Influenza Revealed by Modeling. (2011) Y.N. Naumov, E.N. Naumova, M.B. Yassai, and J. Gorski. J Immunol. 186(11):6617-6624. PMID: 21515795
- Enthalpy-entropy compensation and cooperativity as thermodynamic epiphenomena of structural flexibility in ligand-receptor interactions. (2012) A. Ferrante, and J. Gorski. J Mol Biol. 417(5):454-67. PMID: 22342886
- Emergence of T cells that recognize nonpolymorphic antigens during graft versus host disease.(2012) H. Rangarajan, M. Yassai, H. Subramanian, R. Komorowski, M. Whitaker, J. Gorski, and W.R. Drobyski. Blood. 119: 6354-6364. PMID: 22496151
- A Peptide/MHCII conformer generated in the presence of exchange peptide is substrate for HLA-DM editing.(2012) A. Ferrante and J. Gorski. Sci Rep. 2:386. PMID: 2254519
- Developmental dynamics of post-selection thymic DN iNKT. (2012) M. Yassai, B. Cooley and J. Gorski. PLoS ONE 7(8):e43509. PMID: 22927977.
- Transcriptional Signatures as a Disease-Specific and Predictive Inflammatory Biomarker for Type 1 Diabetes. (2012) H. Levy, X. Wang, M. Kaldunski, S. Jia, J. Kramer, S.J. Pavletich, M. Reske, T. Gessel, M. Yassai, M.W. Quasney, M.K. Dahmer, J. Gorski and M. Hessner. Genes and Immunity 13:593-604.
- Cross-reactive responses to modified M158-66 peptides by CD8+ T cells that do not recognize M158-66 and use non-canonical BV genes can describe unknown repertoires. (2012) G. Petrova and J. Gorski. Eur. J. Immunol. 42:3001-3008. PMID: 22927977.
- The T cell receptor repertoires of regulatory and conventional T cells specific for the same foreign antigen are distinct. (2012) L. Relland, J.B. Williams, G.N. Relland, D. Haribhai, J. Ziegelbauer, M. Yassai, J. Gorski and C.B. Williams. J Immunol. 189:3566-3574. PMID: 22933635.
- The functional CD8 T cell memory recall repertoire responding to the influenza A M158-66 epitope is polyclonal and shows a complex clonotype distribution. (2013) V. Zhou, M.B. Yassai, J. Regunathan, J Box, D. Bosenko, Y. Vashishath, W. Demos, F. Lee, J. Gorski. Hum Immunol. 74:809-817.