Michael B. Dwinell, PhDMichael B. Dwinell, PhD

Microbiology and Immunology
Medical College of Wisconsin

Director, Bobbie Nick Voss Laboratory
Leader, Molecular Cancer Therapeutics

Research Focus: Inflammation and Immunology, Cancer Biology

PhD: University of Wisconsin, Madison (1996) GI Pathophysiology

Dwinell Laboratory: Bobbie Nick Voss Laboratory for Colon Cancer Research

Research Interests
Research in the Dwinell laboratory seeks to define the role for extracellular mediators in the progression and metastasis of solid and hematological cancers. Additional studies are examining the role for metabolic reprogramming to influence tumor progression and exploring new mitochondria-targeted compounds as inhibitors of cancer progression. Human and murine 2D and 3D cell culture systems and preclinical models are being used to investigate the cellular, biochemical, and metabolic signaling pathways that regulate cellular proliferation, programmed cell death and motility in inflammation and cancer. Pharmacokinetic / pharmacodynamics, toxicity and potency / efficacy studies following treatment with small molecule or biologic compounds are also being completed. These translational research studies are multidisciplinary and include molecular cloning, cell culture, biochemical assays and signal processing, histopathology, flow cytometry, and small animal imaging and handling. Completion of these studies will strengthen our identification of new targets for therapeutic intervention to improve human health.to improve human health. There are currently two major research directions in the laboratory.

Research in the Dwinell laboratory is supported through grants from the National Institutes of Health, the Medical College of Wisconsin Cancer Center and philanthropic donations.


Recent Publications:


Contact Information

Dr. Michael Dwinell
Department of Microbiology and Immunology
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226


(414) 955-7427
Room BSB-208 (Basic Science Building)