Research in Acute Kidney Injury

The primary goal of Kevin R. Regner, MD, MS, FASN is to investigate the cellular, molecular, and genetic mechanisms involved in ischemic acute kidney injury (AKI) and kidney repair. Current projects include:

1) Activator of G Protein Signaling 3 in Ischemic Renal Injury. The objective of this study is to characterize the role of Activator of G protein signaling 3 (AGS3), a novel non-receptor regulator of G-protein function, in renal tubular regeneration following ischemic AKI.

2) Genetic mapping and gene identification for acute kidney injury in outbred rats. The objective of this study is to identify novel genes that modulate susceptibility or resistance to AKI using a novel genetic resource, heterogeneous stock rats.

Michael Yeboah, MD, PhD
, has two ongoing projects one of which include:
1) Biomarkers in Hepatorenal Syndrome. Our goal here is to identify novel biomarkers that will help to determine patients at risk of developing the hepatorenal syndrome. The approach involves both animal models and patient level clinical studies.