Diane S. Book, MDDiane S. Book, MD

Associate Professor of Neurology
Medical Director, Froedtert/Medical College Stroke Program

Online Provider Directory Profile Page

Best Doctors 2017-2018


Adult Neurology


  • Stroke and Cerebrovascular Disease:stroke clinic quality, acute stroke therapy, small vessel diseases
  • Dementia


  • Doctor of Medicine, Medical College of Wisconsin, Milwaukee, WI, 1991

Postgraduate Training and Fellowship Appointments

  • Resident, Neurology, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, 1991-1995.
  • Fellow, Behavioral Neurology Fellowship, Stroke/Dementia, Medical College of Wisconsin, Milwaukee, WI, 1995-1996.


  • American Medical Association
  • American Heart Association Stroke Council
  • American Academy of Neurology
  • Wisconsin Stroke Committee


  • Education
    • Alpha Omega Alpha Medical Honor Society
    • American Medical Women's Association Scholastic Achievement Award
    • Phi Beta Kappa
    • Phi Kappa Phi
  • Best Doctors
  • Top Doctors
  • Froedtert & Medical College Stroke & Neurovascular Program receives Joint Commission Primary Stroke Center Certification 2006-present, and American Heart Association Performance Achievement Awards for clinical care quality

Clinical/Research Interests

  • Ischemic Stroke Evaluation and Management
  • Hyperacute Stroke
  • Stroke Education
  • Stroke Care Quality
  • Dementias

Current and Previous Research Projects

  • Secondary Prevention of Small Subcortical Strokes (SPS3); NIH/NINDS , local Principal Investigator

Selected Publications

Original Publications
  1. Tanne, D. , Bates., V., Verro., P., Kasner, S., Binder, J.R., Patel, S., Mansbach, H., Dalet, S., Schultz, L., Karanjia, P., Scott, P., Dayno, J., Vereczey-Porter, K., Benesch, C., Book, D., Coplin, W., Dulli, D., Levine, S. & the t-PA Stroke Survey Group (1999). Initial clinical experience with IV tissue plasminogen activator for acute ischemic stroke: A multicenter survey. Neurology, 53 (2), 424-427.
  2. Tanne, D. et al. , and the tPA Stroke Survey Group (2000). Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke in Patients Aged 80 Years and Older: The tPA Stroke Survey Experience. Stroke, 31, 370-375.
  3. Albers, G.W. et al. (2000). Intravenous tissue-type plasminogen activator for treatment of acute stroke: The Standard Treatment with Alteplase to Reverse Stroke (STARS) Study. JAMA, 283, 1145-1150.
  4. Varelas PN, Sinson G, Rand S, Book D. Clipping the Eagle's wings: treatment of an unusual cause of transient cerebral ischemia. Neurology. 2005 Jan 25;64(2):393-4.
  5. Amarenco A., and the SPARCL Investigators et al., High-Dose Atorvastatin after Stroke or Transient Ischemic Attack, NEJM, 2006; 355 :549-59. (SPARCL study)
Books, Chapters and Reviews
  1. Book, D.S., & Porth, C.: Chapter 50 Disorders of Brain Function. Pathophysiology: Concepts of Altered Health States. 5th edition, Lippincott –Raven Publishers, 2000.
  2. Book, Diane, Muntz, Martin , Jaradeh, Safwan, Neurology Chapter from Concise Textbook of Medicine for Students, 5th edition, Torre, Lamb, Van Ruiswyk, Schapira, Kochar, editors, Lippincott, Williams & Wilkins, 2009.
  3. Journal Reviewer: Cerebrovascular Diseases, Karger Publishers; American Stroke Association International Stroke Conference 2008.