J.R. Falck, PhD

J.R. Falck, PhD


Robert A. Walch Distinguished Chair in Chemistry
UT Southwestern Medical Center

(241) 648-3338 | Fax: (214) 648-8856

Research Interests

  • Medicinal Chemistry
  • Natural Products Isolation and Identification
  • Organometallics
  • Synthetic Methodology
  • Total Synthesis
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  Selected Publications

Tunctan, B., Korkmaz, B., Butaralioglu, C.K., Firat, S.S., Anjaiah, S., Falck, J.R., Roman, R.J., and K.U. Malik: A 20-Hydroxyeicosatetraenoic Acid Agonist, N-[20-Hydroxyeicosa-5(Z),14-(Z)-Dienoyl]Glycine, Opposes the Fall in Blood Pressure and Vascular Reactivity in Endotoxin-Treated Rats. Shock 2008; (30):329-335

Li, D-R., Murugan, A., and J.R. Falck: Enantioselective, Organocatalytic Oxy-Michael Addition to γ/δ-Hydroxy-α,β-enones: Boronate-Amine Complexes as Chiral Hydroxide Synthons.  J. Am. Chem. Soc., 2008; (130):46-48

Illies, C., Gromada, J., Fiume, R., Leibiger, B., Yu, J., Juhl, K., Yang, S-N., Barma, D., Falck, J.R., Saiardi, A., Barker, C.J., and P-O Berggren: Requirement of Inositol Pyrophosphates for Full Exocytotic Capacity in Pancreatic β Cells.  Science 2007; (318):1299-1302

Falck, J.R., He, A., Fukui, H., Tsutsui, H., and A. Radha: Synthesis and Stereochemical Assignment of FR252921, a Promising Immunosuppressant. Angew. Chem. Int. Ed. 2007; (46):4527-4529

Baati, R., Mioskowski, C., Kashinath, D., Kodepelly, S., Lu, B., and J.R. Falck: Stereoselective Synthesis of Methyl (Z)-α-methoxyacrylates via Two-Carbon Homologation of Aldehydes.  Tetrahedron Lett. 2009; (50):402-405

He, A., and J.R. Falck: Synthesis of Enantioenriched α-(Hydroxyalkl)-tri-n-butylstannanes.  Angew. Chem. Int. Ed. 2008; (47):6586-6589

Rasko, D.A., Moriera, C.G., Li, D.R., Readings, N.C., Ritchie, J.M., Waldor, M.K., William, N., Taussig, R., Wei, S., Roth, M., Hughes, D.T., Huntley, J.F., Fina, M.W., Falck, J.R., and V. Sperandio: Targeting QseC Signaling and Virulence for Antibiotic Development. Science 2008; (321):1078-1080

Lu, B., and J.R. Falck: Efficient Iridium-Catalyzed C-H Functionalization/Silylation of Heteroarenes.  Angew. Chem. Int. Ed. 2008; (47):7508-7510