David R. Harder, PhD

David R. Harder, PhDKohler Co. Professor in Cardiovascular Research and Associate Dean for Research

Professor of Physiology, Medicine and Pediatrics

Director for Mentoring – Clinical and Translational Science Institute

(414) 955-8200 | dharder@mcw.edu

MS Physiology, Medical College of Wisconsin, 1975
PhD Biophysics, Medical College of Wisconsin, 1976

Research Interests

Cardiovascular Physiology | Molecular and Cellular Physiology | Neurophysiology

  • Electrophysiology of excitable tissues
    • Ion channels
    • Voltage gated mechanisms
    • Receptor operated mechanisms
  • Cellular mechanisms controlling cerebral blood flow
  • Mechanisms responsible for myogenic activation of arteries
  • Endothelial dependent mechanisms in vascular smooth muscle
  • Biochemistry and molecular biology of membrane lipids in vascular muscle, neurons and their effect on ion channels
  • Cytochrome P450 metabolites in the control of vascular smooth muscle and endothelium
  • Control of renal blood flow
  • Mechanisms controlling autoregulation of blood flow
  • Role of ionic mechanisms in activating arterial and arteriolar smooth muscle
  • Tumor angiogenesis in the brain – behavioral study

Work done on current grants:

Autoregulation of Cerebral Blood Flow

The main goal of this project is to define the genetic factor responsible for autoregulation of cerebral blood flow, including the signaling cascades and ionic mechanisms that mediate pressure-induced myogenic tone.

Astrocyte Secretome: Ability to Modify Phenotype and Genotype of Cells within the CNS

The goal of this project is to identify the factors released by astrocytes and the differences in the cellular components in the newly born vs adult rat.

NIH Biosketch (PDF)

Recent Publications