Acacia Dishman

Structural biology, NMR, metamorphic proteins

Research Experience

Medical College of Wisconsin, 2017-present
Advisor: Brian Volkman, PhD
Project: Structure-Function Investigation of Chemokine-GPCR Signaling in Tumor Progression and Metastasis (F30CA236182)

University of Washington, 2020
Visiting Scientist
Advisor: David Baker, PhD
De novo design and characterization of fold switching proteins

University of Michigan, Ann Arbor, 2011-2015
Advisor: Joerg Lahann, PhD
Fabrication of multi-compartmental, biodegradable polymer nano and micro particles for drug delivery applications

Karlsruhe Institute for Technology, Germany, 2014
Advisors: Joerg Lahann, Yvonne Leonie Barner
Fabrication of biphasic, biodegradable polyanhydride micorparticles for Cystic Fibrosis drug delivery applications

Publications

Dishman AF and Lee MW, de Anda J, Lee EY, He J, Huppler AR, Wong GCL, Volkman BF. (2020). Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1. ACS Infectious Diseases.

Fox JC, Thomas MA, Dishman AF, Larsen O, Nakayama T, Yoshie O, Rosenkilde MM, Volkman BF. (2019). Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1. Science Signaling.

Dishman AF, Volkman BF. “Unfolding the Mysteries of Protein Metamorphosis.” ACS Chem Biol. 13(6):1438-1446. 2018

S. Rahmani, S. Ashraf, R. Hartmann, A. F. Dishman, M. V. Zyuzin, C. K. J. Yu, W. J. Parak, J. Lahann. "Engineering of Nanoparticle Size via Electrohydrodynamic Jetting." Bioengineering and Translational Medicine, 2016, 1, 82–93.

A. M. Ross, S. Rahmani, D. M. Prieskorn, A. F. Dishman, J. M. Miller, J. Lahann, R. A. Altschuler. "Persistence, distribution, and impact of distinctly segmented microparticles on cochlear health following in vivo infusion." J. Biomedical Materials Research Part A, 2016, 104 (6) 1510-1522.

S. Rahmani, C. H. Villa, A. F. Dishman, M. E. Grabowski, D. C. Pan, H. Durmaz, A. C. Misra, L. Colón-Meléndez, M. J. Solomon,V. R. Muzykantov, J. Lahann. "Long-circulating Janus nanoparticles made by electrohydrodynamic co-jetting for systemic drug delivery applications." J. Drug Targeting, 2015, 23 (7-8), 750-758.

S. Rahmani, T.-H. Park, A. F. Dishman, J. Lahann, “Multimodal Delivery of Irinotecan from Microparticles with Two Distinct Compartments.” J. Control. Release, 2013, 172, 239-245.

S. Rahmani, A. M. Ross, T. H. Park, H. Durmaz, A. F. Dishman, D. Prieskorn, N. Jones, R. Altschuler, J. Lahann. “Dual Release Carriers for Cochlear Delivery.” Adv. Healthcare Mat., 2015, 4, 1-7.

Meeting Abstracts

Dishman AF, Tyler RC, Fox JC, Lee MW, de Anda J, Lee EY, He J, Wong GCL, Volkman BF. Evolution and Functional Advantages of Protein Metamorphosis. Biophysical Society Annual Meeting. San Diego, CA, Feb 2020.

Dishman AF, Lee, MW, Fox, JC, Thomas, MA, Wong, GW, Volkman, BF. Structure-activity relationships in the metamorphic, antimicrobial protein XCL1. 34th Annual MD/PhD National Student Conference. Copper Mountain, CO, July, 2020.

Dishman AF, Lee, MW, Fox, JC, Thomas, MA, Wong, GW, Volkman, BF. Structure-activity relationships in the metamorphic, antimicrobial protein XCL1. Protein Society 33rd Annual Symposium. Seattle, WA, June 2019.

General Interests

Running, biking, hiking, traveling