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Alexander Dayton

AlexanderDayton

Alexander Dayton

M4 Student

Locations

  • Medical Scientist Training Program

Contact Information

Biography

Education

BA, Chemistry and Math, Hanover College, 2009

Faculty Advisor

Allen W. Cowley, Jr., PhD, Physiology

Research Interests

I use Bayesian statistical methods to characterize the effects of heretofore unknown genes on a rat model of salt-sensitive hypertension.

Research Experience

Indiana University, 2007, Research Assistant

The Ohio State University, 2009-2011, Research Assistant

Publications

He S, Dayton A, Kuppusamy P, Werbovetz KA, Drew ME. Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40. Antimicrob Agents Chemother. 2012 May;56(5):2428-34. Epub 2012 Feb 6.

Selvendiran K, Ahmed S, Dayton A, Kuppusamy ML, Rivera BK, Kálai T, Hideg K, Kuppusamy P. HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. Cancer Biol Ther. 2011 Nov 1;12(9):837-45. Epub 2011 Nov 1.

Dayton A, Selvendiran K, Meduru S, Khan M, Kuppusamy ML, Naidu S, Kálai T, Hideg K, Kuppusamy P. Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867. J Pharmacol Exp Ther. 2011 Nov;339(2):350-7. Epub 2011 Jul 28.

Dayton A, Selvendiran K, Kuppusamy ML, Rivera BK, Meduru S, Kálai T, Hideg K, Kuppusamy P. Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties. Cancer Biol Ther. 2010 Nov;10(10):1027-32. Epub 2010 Nov 15.

Selvendiran K, Ahmed S, Dayton A, Ravi Y, Kuppusamy ML, Bratasz A, Rivera BK, Kálai T, Hideg K, Kuppusamy P. HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase. Mol Cancer Res. 2010 Sep;8(9):1188-97. Epub 2010 Aug 16.

Selvendiran K, Ahmed S, Dayton A, Kuppusamy ML, Tazi M, Bratasz A, Tong L, Rivera BK, Kálai T, Hideg K, Kuppusamy P. Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells. Free Radic Biol Med. 2010 May 1;48(9):1228-35. Epub 2010 Feb 12.

General Interests

Soccer, video games, books