Antje Kroner-Milsch, MD, PhD

Assistant Professor

Locations

Clement J. Zablocki VA Medical Center
Neuroscience Research Labs – Research 151
5000 W. National Ave.
Milwaukee, WI 53295

Biography

Dr. Kroner-Milsch received her MD degree at Julius-Maximilian University, Wuerzburg, Germany in 2002. In 2008, she completed her PhD in Neuroscience under supervision of Dr. Rudolf Martini at Julius-Maximilian University in Wuerzburg investigating the role of immune cells in hereditary myelinopathies.

Following graduation she conducted a postdoctoral fellowship at McGill University in Montreal, Canada in Dr. Sam David’s laboratory. During her postdoctoral fellowship, she started working in the field of spinal cord injury. In 2014, she was promoted to Research Associate. Her work in Dr. David’s laboratory focused on the inflammatory response after spinal cord injury, in particular on the role of macrophages.

Dr. Kroner-Milsch joined the Medical College of Wisconsin in September, 2015 and is an Assistant Professor in the Department of Neurosurgery. She continues to explore the role of inflammation after spinal cord injury and aims to modify the inflammatory response in order to achieve improved outcome after spinal cord injury.

Honors and Awards

09/01/2005 – Young Investigator Award Multiple Sclerosis, Wyeth

Education

MD, Julius-Maximilians-University, Wuerzburg, Germany, 2002
PhD, Julius-Maximilians-University, Wuerzburg, Germany, 2008
Postdoctoral Fellow, Neurology, Developmental Neurobiology, Julius-Maximilians-University, Josef Schneider Strasse, Wuerzburg, Germany, 2008-2009
Postdoctoral Fellow, Neurology, Centre for Research in Neuroscience, McGill University Health Centre, Montreal, Quebec, 2009-2014
Research Associate, Neurology, Centre for Research in Neuroscience, McGill University Health Centre, Montreal, Quebec, 2014-2015

Research Interests

Therapeutic potential of modifying the inflammatory response after spinal cord injury

Myeloid cell responses after spinal cord injury.

(David S, Kroner A, Greenhalgh AD, Zarruk JG, López-Vales R.) J Neuroimmunol. 2018 Aug 15;321:97-108.
Small-Molecule Stabilization of 14-3-3 Protein-Protein Interactions Stimulates Axon Regeneration.

(Kaplan A, Morquette B, Kroner A, Leong S, Madwar C, Sanz R, Banerjee SL, Antel J, Bisson N, David S, Fournier AE.) Neuron. 2017 Mar 08;93(5):1082-1093.e5.
Arginase-1 is expressed exclusively by infiltrating myeloid cells in CNS injury and disease.

(Greenhalgh AD, Passos Dos Santos R, Zarruk JG, Salmon CK, Kroner A, David S.) Brain Behav Immun. 2016 Aug;56:61-7.
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients.

(Sadovnick AD, Traboulsee AL, Bernales CQ, Ross JP, Forwell AL, Yee IM, Guillot-Noel L, Fontaine B, Cournu-Rebeix I, Alcina A, Fedetz M, Izquierdo G, Matesanz F, Hilven K, Dubois B, Goris A, Astobiza I, Alloza I, Antigüedad A, Vandenbroeck K, Akkad DA, Aktas O, Blaschke P, Buttmann M, Chan A, Epplen JT, Gerdes LA, Kroner A, Kubisch C, Kümpfel T, Lohse P, Rieckmann P, Zettl UK, Zipp F, Bertram L, Lill CM, Fernandez O, Urbaneja P, Leyva L, Alvarez-Cermeño JC, Arroyo R, Garagorri AM, García-Martínez A, Villar LM, Urcelay E, Malhotra S, Montalban X, Comabella M, Berger T, Fazekas F, Reindl M, Schmied MC, Zimprich A, Vilariño-Güell C.) G3 (Bethesda). 2016 07 07;6(7):2073-9.
Role of IL-10 in Resolution of Inflammation and Functional Recovery after Peripheral Nerve Injury.

(Siqueira Mietto B, Kroner A, Girolami EI, Santos-Nogueira E, Zhang J, David S.) J Neurosci. 2015 Dec 16;35(50):16431-42.
Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS.

(Schrewe L, Lill CM, Liu T, Salmen A, Gerdes LA, Guillot-Noel L, Akkad DA, Blaschke P, Graetz C, Hoffjan S, Kroner A, Demir S, Böhme A, Rieckmann P, ElAli A, Hagemann N, Hermann DM, Cournu-Rebeix I, Zipp F, Kümpfel T, Buttmann M, Zettl UK, Fontaine B, Bertram L, Gold R, Chan A.) J Neuroinflammation. 2015 Dec 16;12:234.
Genome-wide significant association with seven novel multiple sclerosis risk loci.

(Lill CM, Luessi F, Alcina A, Sokolova EA, Ugidos N, de la Hera B, Guillot-Noël L, Malhotra S, Reinthaler E, Schjeide BM, Mescheriakova JY, Mashychev A, Wohlers I, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Astobiza I, Blaschke P, Boyko AN, Buttmann M, Chan A, Dörner T, Epplen JT, Favorova OO, Fedetz M, Fernández O, García-Martínez A, Gerdes LA, Graetz C, Hartung HP, Hoffjan S, Izquierdo G, Korobko DS, Kroner A, Kubisch C, Kümpfel T, Leyva L, Lohse P, Malkova NA, Montalban X, Popova EV, Rieckmann P, Rozhdestvenskii AS, Schmied C, Smagina IV, Tsareva EY, Winkelmann A, Zettl UK, Binder H, Cournu-Rebeix I, Hintzen R, Zimprich A, Comabella M, Fontaine B, Urcelay E, Vandenbroeck K, Filipenko M, Matesanz F, Zipp F, Bertram L.) J Med Genet. 2015 Dec;52(12):848-55.
Macrophage and microglial plasticity in the injured spinal cord.

(David S, Greenhalgh AD, Kroner A.) Neuroscience. 2015 Oct 29;307:311-8.
Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulation.

(Zarruk JG, Berard JL, Passos dos Santos R, Kroner A, Lee J, Arosio P, David S.) Neurobiol Dis. 2015 Sep;81:93-107.
TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord.

(Kroner A, Greenhalgh AD, Zarruk JG, Passos Dos Santos R, Gaestel M, David S.) Neuron. 2014 Sep 03;83(5):1098-116.
Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis.

(Lill CM, Schilling M, Ansaloni S, Schröder J, Jaedicke M, Luessi F, Schjeide BM, Mashychev A, Graetz C, Akkad DA, Gerdes LA, Kroner A, Blaschke P, Hoffjan S, Winkelmann A, Dörner T, Rieckmann P, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Zipp F, Bertram L.) Neurogenetics. 2014 May;15(2):129-34.
MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis.

(International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández Ó, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L, Zipp F.) Brain. 2013 Jun;136(Pt 6):1778-82.

Antje Kroner-Milsch, MD, PhD