Balaraman Kalyanaraman, PhD
Professor and Chair; Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research; Founder, Free Radical Research Center; Associate Director of Basic Research, Center for Disease Prevention Research
Visiting Fellow, Chemistry, Laboratory of Environmental Biophysics, National Institute of Environmental Sciences, Research Triangle Park, NC, 1978-1981
PhD, Chemistry, University of Alabama, Tuscaloosa, AL, 1978
MS, Chemistry, Indian Institute of Technology, Mumbai (formerly Bombay), India, 1972
BS, Chemistry, Loyola College, University of Madras, Chennai, India, 1970
In 1981, I joined the Biophysics section of the Department of Radiology at the Medical College of Wisconsin; in 1984, I became an assistant professor in the Department of Radiology; and in 1989, I became an associate professor in the Department of Biophysics. Currently, I am professor and chair of the Department of Biophysics. I have served as an associate editor for Free Radicals in Biology and Medicine,Free Radical Research, and Biochemical Journal.
My research interests are centered on the application of EPR in free radical biology and understanding the role of oxidants and antioxidants in signal transduction and apoptosis. My specific research areas are outlined below.
- Chemistry and Biophysics
- Detection of reactive oxygen and nitrogen species by EPR spin-trapping, fluorescence, optical stopped-flow, and HPLC techniques
- Syntheses of mitochondrially targeted spin traps, spin labels, and ROS-specific fluorescence probes
- EPR studies of mitochondria
- Mechanism of Signal Transduction/Cell Signaling
- Mitochondrial STAT3 and redox signaling
- Oxidant-induced iron signaling and apoptosis
- Chemotherapeutic drug toxicity and prevention (e.g., doxorubicin); mechanism of apoptosis in tumor cells and normal cells
- Mechanism of Disease
- Role of mitochondria-derived oxidants in chemically induced Parkinsonism (e.g., MPTP, rotenone) in cell culture and animal models; mechanism of protein aggregation, proteosomal dysfunction, and apoptotic neuronal cell death
- Targeting of metabolism, bioenergetics, and redox signaling in cancer
- Development of new mitochondria-targeted antitumor and antiproliferative drugs
My research projects include the following:
- Targeting Pancreatic Cancer Energy Metabolism, Tumor Growth, and Metastasis
The overall goal of this project is to develop new therapeutic approaches to inhibit PDAC malignancy.
- CYP2E1 Mediated Mitochondrial Injury and Cell Damage in Alcohol Liver Disease
A major objective here is to investigate the mechanisms of alcohol induced mitochondrial dysfunction and develop antioxidants and enzyme inhibitors to minimize alcohol induced liver damage.
Gang Cheng, PhD, Research Scientist II
Donna McAllister, Research Associate I
Laura McOlash, Research Technologist III
Monika Zielonka, Research Technologist III
(Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B.) Free Radic Biol Med. 2020 Feb 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019
An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids.
(Zhu BZ, Xu D, Qin L, Huang CH, Xie LN, Mao L, Shao J, Kalyanaraman B.) Free Radic Biol Med. 2020 Jan;146:150-159 PMID: 31302229 SCOPUS ID: 2-s2.0-85075485756 07/16/2019
Molecular mechanism for the activation of the anti-tuberculosis drug isoniazid by Mn(III): First detection and unequivocal identification of the critical N-centered isoniazidyl radical and its exact location.
(Qin L, Huang CH, Xu D, Xie LN, Shao J, Mao L, Kalyanaraman B, Zhu BZ.) Free Radic Biol Med. 2019 Nov 01;143:232-239 PMID: 31319159 SCOPUS ID: 2-s2.0-85070677474 07/19/2019
(Besson E, Gastaldi S, Bloch E, Zielonka J, Zielonka M, Kalyanaraman B, Aslan S, Karoui H, Rockenbauer A, Ouari O, Hardy M.) Analyst. 2019 Jul 21;144(14):4194-4203 PMID: 31180410 SCOPUS ID: 2-s2.0-85068588717 06/11/2019
(Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A.) Breast Cancer Res. 2019 06 15;21(1):74 PMID: 31202267 PMCID: PMC6570928 SCOPUS ID: 2-s2.0-85067234098 06/17/2019
(Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B.) Oncotarget. 2019 May 28;10(37):3518-3532 PMID: 31191823 PMCID: PMC6544408 06/14/2019
(Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, Chen G, Kresty L, Kalyanaraman B, You M.) Nat Commun. 2019 05 17;10(1):2205 PMID: 31101821 PMCID: PMC6525201 SCOPUS ID: 2-s2.0-85065824371 05/19/2019
(Zielonka J, Zielonka M, Cheng G, Hardy M, Kalyanaraman B.) Methods Mol Biol. 2019;1982:429-446 PMID: 31172487 PMCID: PMC6953630 SCOPUS ID: 2-s2.0-85067079084 06/07/2019
(Zielonka J, Zielonka M, Kalyanaraman B.) Methods Mol Biol. 2019;1982:243-258 PMID: 31172476 PMCID: PMC6953631 SCOPUS ID: 2-s2.0-85066970086 06/07/2019
(Kalyanaraman B.) Redox Biology. January 2020;29 SCOPUS ID: 2-s2.0-85075628069 01/01/2020
(Xu D, Huang CH, Xie LN, Shao B, Mao L, Shao J, Kalyanaraman B, Zhu BZ.) Carcinogenesis. 2019 Jan 08 PMID: 30870561 03/15/2019