Internal Medicine, Saint Luke's Hospital, Milwaukee, Wisconsin (2009)
Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin (2013)
Radiation Oncology, American Board of Radiology (2014)
MD, Medical College of Wisconsin, Milwaukee, WI, 2008
PhD, Cell Biology, Medical College of Wisconsin, Milwaukee, WI 2006
MPhil, Epidemiology, Cambridge University, Cambridge, UK, 1999
SB, Chemical Engineering and Biology, MIT, Cambridge, MA, 1988
Members of the Rho, Rac, Ras, and Rap families of small GTPases regulate cancer development and progression. In addition, Ras and other small GTPases can alter the sensitivity of cancer cells to radiation and chemotherapy. Identifying new ways to suppress small GTPase activation in cancers may provide new treatment approaches. While most small GTPases promote cancer and are oncogenic, a few of the small GTPase family members are actually tumor suppressors. Our laboratory studies members of the small GTPase family which have tumor suppressor activities.
The DIRAS family of small GTPases has the unique property of having tumor suppressive actions, rather than the tumor promoting actions common to most other small GTPases. DIRAS1 and DIRAS2 are poorly characterized thus far, with the literature consisting of only a few publications demonstrating tumor suppressor functions in central nervous system and esophageal malignancies. DIRAS3 (ARHI) is the most studied of the DIRAS proteins. DIRAS3 is downregulated or lost in 40-70% of ovarian and breast cancers. Overexpression of DIRAS1 inhibits Ras-mediated cellular transformation of NIH3T3 cells, and DIRAS3 dramatically inhibits cells growth of breast and ovarian cancer cells. Our laboratory is currently studying the roles of DIRAS signaling in breast cancer and other malignancies.
Our long-term goal is to understand how small GTPases can be manipulated to enhance cancer treatment. The knowledge obtained from our studies may help define novel signaling pathways that modulate the functions of pro-oncogenic small GTPases in the Ras family. We hypothesize that knowledge of DIRAS family tumor suppressive signaling can identify new targets for cancer therapeutics and help to identify novel ways in which to abolish pro-oncogenic small GTPase signaling which is critical in the development and progression of a number of malignancies.
(Currey A, Patten CR, Bergom C, Wilson JF, Kong AL.) Breast J. 2018 Nov;24(6):902-910.
(Flister MJ, Bergom C.) Trends Cancer. 2018 Jun;4(6):429-444.
(Bergom C, Currey A, Desai N, Tai A, Strauss JB.) Front Oncol. 2018;8:87.
(Jagtap J, Sharma G, Parchur AK, Gogineni V, Bergom C, White S, Flister MJ, Joshi A.) Biomed Opt Express. 2018 Feb 01;9(2):543-556.
(Maranto C, Udhane V, Hoang DT, Gu L, Alexeev V, Malas K, Cardenas K, Brody JR, Rodeck U, Bergom C, Iczkowski KA, Jacobsohn K, See W, Schmitt SM, Nevalainen MT.) Clin Cancer Res. 2018 Apr 15;24(8):1917-1931.
(Kimmick GG, Li X, Fleming ST, Sabatino SA, Wilson JF, Lipscomb J, Cress R, Bergom C, Anderson RT, Wu XC, Written on behalf of the Center for Disease Control and Prevention National Program of Cancer Registry Patterns of Care Study Group.) J Geriatr Oncol. 2018 May;9(3):214-220.
Precision Oncology and Genomically Guided Radiation Therapy: A Report From the American Society for Radiation Oncology/American Association of Physicists in Medicine/National Cancer Institute Precision Medicine Conference.
(Hall WA, Bergom C, Thompson RF, Baschnagel AM, Vijayakumar S, Willers H, Li XA, Schultz CJ, Wilson GD, West CML, Capala J, Coleman CN, Torres-Roca JF, Weidhaas J, Feng FY.) Int J Radiat Oncol Biol Phys. 2018 Jun 01;101(2):274-284.
(Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL.) Oncogene. 2017 12 14;36(50):6873-6883.
(Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A.) Breast Cancer Res Treat. 2017 Aug;165(1):53-64.
(Fish BL, Gao F, Narayanan J, Bergom C, Jacobs ER, Cohen EP, Moulder JE, Orschell CM, Medhora M.) Health Phys. 2016 11;111(5):410-9.
(Bergom C, Kelly T, Bedi M, Saeed H, Prior P, Rein LE, Szabo A, Wilson JF, Currey AD, White J.) Int J Radiat Oncol Biol Phys. 2016 09 01;96(1):65-71.
(Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL.) J Biol Chem. 2016 May 13;291(20):10948.