
David R. Harder, PhD
Kohler Co. Professor in Cardiovascular Research and Associate Dean for Research; Professor of Physiology, Medicine and Pediatrics; Director for Mentoring, Clinical and Translational Science Institute
Locations
- Physiology
Contact Information
Biography
Education
PhD, Biophysics, Medical College of Wisconsin, 1976
MS, Physiology, Medical College of Wisconsin, 1975
Research Interests
Cardiovascular Physiology | Molecular and Cellular Physiology | Neurophysiology
- Ion channels
- Voltage gated mechanisms
- Receptor operated mechanisms
Work done on current grants:
Autoregulation of Cerebral Blood Flow
The main goal of this project is to define the genetic factor responsible for autoregulation of cerebral blood flow, including the signaling cascades and ionic mechanisms that mediate pressure-induced myogenic tone.
Astrocyte Secretome: Ability to Modify Phenotype and Genotype of Cells within the CNS
The goal of this project is to identify the factors released by astrocytes and the differences in the cellular components in the newly born vs adult rat.
NIH Biosketch (PDF)
Publications
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(Gebremedhin D, Zhang DX, Weihrauch D, Uche NN, Harder DR.) PLoS One. 2017;12(5):e0176796.
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(Zhang H, Falck JR, Roman RJ, Harder DR, Koehler RC, Yang ZJ.) Cell Mol Neurobiol. 2017 Oct;37(7):1279-1286.
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(Zhang Y, Hong G, Lee KS, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A.) J Neurochem. 2017 03;140(5):814-825.
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(Gebremedhin D, Zhang DX, Carver KA, Rau N, Rarick KR, Roman RJ, Harder DR.) Prostaglandins Other Lipid Mediat. 2016 07;124:16-26.
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(Gebremedhin D, David Zhang X, Carver K, Rau N, Roman, R, Harder DR.) Elsevier . .
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(Zhang Y, Hong G, Lee KS, Hammock B, Gebremedhin D, Koehler R, Harder DR, Sapirstein A.) Journal of Neurochemistry. .
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(Hye Khan MA, Sharma A, Rarick KR, Roman RJ, Harder DR, Imig JD.) PLoS One. 2015;10(12):e0145335.
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Correction: Astrocytes Directly Influence Tumor Cell Invasion and Metastasis In Vivo.
(Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R.) PLoS One. 2015;10(8):e0137369.
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Contribution of epoxyeicosatrienoic acids to the cerebral blood flow response to hypoxemia.
(Liu X, Gebremedhin D, Harder DR, Koehler RC.) J Appl Physiol (1985). 2015 Nov 15;119(10):1202-9.
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(Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ.) PLoS One. 2014;9(11):e112878.
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(Carver KA, Lourim D, Tryba AK, Harder DR.) Am J Physiol Cell Physiol. 2014 Dec 01;307(11):C989-98.
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(Pabbidi MR, Mazur O, Fan F, Farley JM, Gebremedhin D, Harder DR, Roman RJ.) Am J Physiol Heart Circ Physiol. 2014 Apr 01;306(7):H989-H1000.