Eric Darrah, PhD

I am interested in the viral manipulation of host molecular processes and their role in negotiating a chronic infection within the host organism.

Research Experience

Medical College of Wisconsin, 2014-2019
Advisor: Vera Tarakanova, PhD
Project: Viral manipulation of host molecular processes

University of Iowa,  2010-2012
Advisor: Bridget Lear, PhD
Project: Investigating the role of ion-channels in determining Drosophila circadian rhythms

University of Iowa, 2008-2010
Advisor: Daniel Eberl, PhD
Project: Investigating genes involved in cilia structure and function

Publications

Darrah EJ, Jondle CN, Johnson KE, et al. Conserved Gammaherpesvirus Protein Kinase Selectively Promotes Irrelevant B Cell Responses. J Virol. 2019;93(8):e01760-18. Published 2019 Apr 3. doi:10.1128/JVI.01760

Lange PT, Jondle CN, Darrah EJ, et al. LXR Alpha restricts gammaherpesvirus reactivation from latently infected peritoneal cells. J Virol.2019,93(6):e02071-18. Mar 2019. doi:10.1128/JVI.02071-18

Darrah EJ, Stoltz KP, Ledwith M, Tarakanova VL. ATM supports gammaherpesvirus replication by attenuating type I interferon pathway. Virology. 2017;510:137-146. doi:10.1016/j.virol.2017.07.014

Darrah EJ, Kulinski JM, Mboko WP, et al. B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection. J Virol. 2017;91(19):e01103-17. Published 2017 Sep 12. doi:10.1128/JVI.01103-17

Rekow MM, Darrah EJ, Mboko WP, Lange PT, Tarakanova VL. Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency. Virology. 2016;492:140-144. doi:10.1016/j.virol.2016.02.022

Lange PT, Darrah EJ, Vonderhaar EP, Mboko WP, Rekow MM, Patel SB, Sidjanin DJ, Tarakanova VL. Type I Interferon Counteracts Antiviral Effects of Statins in the Context of Gammaherpesvirus Infection. J Virol. 2016 Jan 6;90(7):3342-54. doi: 10.1128/JVI.02277-15. PubMed PMID: 26739055; PubMed Central PMCID: PMC4794672.

Mboko WP, Olteanu H, Ray A, Xin G, Darrah EJ, et al. Tumor Suppressor Interferon-Regulatory Factor 1 Counteracts the Germinal Center Reaction Driven by a Cancer-Associated Gammaherpesvirus. J Virol. 2015;90(6):2818-2829. Published 2015 Dec 30. doi:10.1128/JVI.02774-15

Kulinski JM, Darrah EJ, Broniowska KA, et al. ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection. Virology. 2015;483:264-274. doi:10.1016/j.virol.2015.04.026

Mboko WP, Mounce BC, Emmer J, Darrah E, Patel SB, Tarakanova VL. Interferon regulatory factor 1 restricts gammaherpesvirus replication in primary immune cells. J Virol. 2014 Jun;88(12):6993-7004.

Lear BC, Darrah EJ, Aldrich BT, Gebre S, Scott RL, Nash HA, Allada R. UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila. PLoS One. 2013 Nov 5;8(11):e78147.