Hallgeir Rui, MD, PhD

WBCS Endowed Professor of Breast Cancer Research; Director, MCW Tissue Bank; Professor and Vice Chair of Research, Pathology

Locations

Pathology & Laboratory Medicine
TBRC

Contact Information

General Interests

Breast Cancer Research

Education

MD, University of Oslo, Oslo, Norway
PhD, Pathology, University of Oslo, Oslo, Norway

Biography

Hallgeir Rui, MD, PhD is internationally recognized for his research on hormone signaling in breast cancer, and has a strong track record of leadership, mentoring and collaboration. He is the WBCS Endowed Professor of Breast Cancer Research at the Medical College of Wisconsin (MCW), with his primary appointment in the Department of Pathology, and a secondary appointment to the Department of Pharmacology & Toxicology. In addition, Dr. Rui serves as the Associate Director of Basic Science and Shared Resources at the MCW Cancer Center. With his past experience as a Program Leader and Shared Resource Director at the NCI-designated Sidney Kimmel Cancer Center at Thomas Jefferson University, Dr. Rui brings valuable experience to the MCW Cancer Center efforts toward NCI-designation. Dr. Rui serves on the Breast Cancer Translational Research Committee of NRG Oncology.

Research Interests

Breast Cancer

Cytokine receptors

Hormones: Estrogen, growth, glucocorticoid, steroid

Endocrinology

Prolactin and Prolactin receptors

Jak2, Stat5, Stat5a, Stat5b

Immunohistochemistry

Pathology

Biomarkers

Early detection

Tissue microarray

Mouse modeling

EGFR, Her2, ErbB2

The membrane-associated form of cyclin D1 enhances cellular invasion.

(Chen K, Jiao X, Ashton A, Di Rocco A, Pestell TG, Sun Y, Zhao J, Casimiro MC, Li Z, Lisanti MP, McCue PA, Shen D, Achilefu S, Rui H, Pestell RG.) Oncogenesis. 2020 Sep 18;9(9):83 PMID: 32948740 PMCID: PMC7501870 SCOPUS ID: 2-s2.0-85091177817 09/20/2020
Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis.

(Cho C, Mukherjee R, Peck AR, Sun Y, McBrearty N, Katlinski KV, Gui J, Govindaraju PK, Puré E, Rui H, Fuchs SY.) Oncogene. 2020 Sep;39(38):6129-6137 PMID: 32807917 PMCID: PMC7502515 SCOPUS ID: 2-s2.0-85089539324 08/19/2020
Individualized multi-omic pathway deviation scores using multiple factor analysis.

(Rau A, Manansala R, Flister MJ, Rui H, Jaffrézic F, Laloë D, Auer PL.) Biostatistics. 2020 Aug 06 PMID: 32766691 08/09/2020
Malignant cell-specific pro-tumorigenic role of type I interferon receptor in breast cancers.

(Odnokoz O, Yu P, Peck AR, Sun Y, Kovatich AJ, Hooke JA, Hu H, Mitchell EP, Rui H, Fuchs SY.) Cancer Biol Ther. 2020 Jul 02;21(7):629-636 PMID: 32378445 PMCID: PMC7515508 SCOPUS ID: 2-s2.0-85084376942 05/08/2020
Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury.

(Schlaak RA, Frei A, Fish BL, Harmann L, Gasperetti T, Pipke JL, Sun Y, Rui H, Flister MJ, Gantner BN, Bergom C.) Cancers (Basel). 2020 Apr 16;12(4) PMID: 32316187 PMCID: PMC7226421 04/23/2020
Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer.

(Morita Y, Leslie M, Kameyama H, Lokesh GLR, Ichimura N, Davis R, Hills N, Hasan N, Zhang R, Kondo Y, Gorenstein DG, Volk DE, Chervoneva I, Rui H, Tanaka T.) Cancers (Basel). 2020 Mar 19;12(3) PMID: 32204492 PMCID: PMC7140021 03/25/2020
Neuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome.

(Plasterer C, Tsaih SW, Peck AR, Chervoneva I, O'Meara C, Sun Y, Lemke A, Murphy D, Smith J, Ran S, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Mitchell EP, Bergom C, Joshi A, Auer P, Prokop J, Rui H, Flister MJ.) Breast Cancer Res Treat. 2019 Aug;177(1):77-91 PMID: 31165373 SCOPUS ID: 2-s2.0-85066986189 06/06/2019
The p52 isoform of SHC1 is a key driver of breast cancer initiation.

(Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A.) Breast Cancer Res. 2019 06 15;21(1):74 PMID: 31202267 PMCID: PMC6570928 SCOPUS ID: 2-s2.0-85067234098 06/17/2019
Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3.

(Schlaak RA, Frei A, Schottstaedt AM, Tsaih SW, Fish BL, Harmann L, Liu Q, Gasperetti T, Medhora M, North PE, Strande JL, Sun Y, Rui H, Flister MJ, Bergom C.) Am J Physiol Heart Circ Physiol. 2019 06 01;316(6):H1267-H1280 PMID: 30848680 PMCID: PMC6620678 SCOPUS ID: 2-s2.0-85066837925 03/09/2019
Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients.

(Plasterer C, Tsaih SW, Lemke A, Schilling R, Dwinell M, Rau A, Auer P, Rui H, Flister MJ.) G3 (Bethesda). 2019 05 07;9(5):1739-1743 PMID: 30914425 PMCID: PMC6505137 SCOPUS ID: 2-s2.0-85065792535 03/28/2019
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.

(Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, Matheson NJ, Antrobus R, Ludwig S, Whiteside TL, Sander C, Tarhini AA, Kirkwood JM, Lehner PJ, Guo W, Rui H, Minn AJ, Koumenis C, Diehl JA, Fuchs SY.) Cancer Cell. 2019 01 14;35(1):33-45.e6 PMID: 30645975 PMCID: PMC6336114 SCOPUS ID: 2-s2.0-85058438732 01/16/2019
Mapping Mammary Tumor Traits in the Rat.

(Flister MJ, Joshi A, Bergom C, Rui H.) Methods Mol Biol. 2019;2018:249-267 PMID: 31228161 SCOPUS ID: 2-s2.0-85068143262 06/23/2019

Hallgeir Rui, MD, PhD