Hallgeir Rui, MD, PhD

WBCS Endowed Professor of Breast Cancer Research; Director, MCW Tissue Bank; Professor and Vice Chair of Research, Pathology

Locations

Pathology & Laboratory Medicine
TBRC

Contact Information

General Interests

Breast Cancer Research

Education

MD, University of Oslo, Oslo, Norway
PhD, Pathology, University of Oslo, Oslo, Norway

Biography

Hallgeir Rui, MD, PhD is internationally recognized for his research on hormone signaling in breast cancer, and has a strong track record of leadership, mentoring and collaboration. He is the WBCS Endowed Professor of Breast Cancer Research at the Medical College of Wisconsin (MCW), with his primary appointment in the Department of Pathology, and a secondary appointment to the Department of Pharmacology & Toxicology. In addition, Dr. Rui serves as the Associate Director of Basic Science and Shared Resources at the MCW Cancer Center. With his past experience as a Program Leader and Shared Resource Director at the NCI-designated Sidney Kimmel Cancer Center at Thomas Jefferson University, Dr. Rui brings valuable experience to the MCW Cancer Center efforts toward NCI-designation. Dr. Rui serves on the Breast Cancer Translational Research Committee of NRG Oncology.

Research Interests

Breast Cancer

Cytokine receptors

Hormones: Estrogen, growth, glucocorticoid, steroid

Endocrinology

Prolactin and Prolactin receptors

Jak2, Stat5, Stat5a, Stat5b

Immunohistochemistry

Pathology

Biomarkers

Early detection

Tissue microarray

Mouse modeling

EGFR, Her2, ErbB2

Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness.

(Felix JC, Sheinin YM, Suster D, Ronen N, Ratiani M, Vanden Heuvel T, Winge E, Patton MD, Rau MJ, Ge L, Sun Y, Udhane SS, Langenheim JF, Rui H.) Ann Diagn Pathol. 2021 Aug;53:151744 PMID: 33991784 PMCID: PMC8053602 SCOPUS ID: 2-s2.0-85105597450 05/16/2021
Leveraging Antiprogestins in the Treatment of Metastatic Breast Cancer.

(Kamaraju S, Fowler AM, Weil E, Wisinski KB, Truong TH, Lehr M, Chaudhary LN, Cheng YC, Chitambar CR, Rui H, Yee D, Lange C.) Endocrinology. 2021 Aug 01;162(8) PMID: 33735382 03/19/2021
Quantification of spatial tumor heterogeneity in immunohistochemistry staining images.

(Chervoneva I, Peck AR, Yi M, Freydin B, Rui H.) Bioinformatics. 2021 06 16;37(10):1452-1460 PMID: 33275142 PMCID: PMC8208754 SCOPUS ID: 2-s2.0-85108385952 12/05/2020
Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature.

(Puzyrenko A, Felix JC, Sun Y, Rui H, Sheinin Y.) Pathol Res Pract. 2021 Apr;220:153380 PMID: 33676105 PMCID: PMC7883708 SCOPUS ID: 2-s2.0-85101878778 03/07/2021
Prolonged Time from Diagnosis to Breast-Conserving Surgery is Associated with Upstaging in Hormone Receptor-Positive Invasive Ductal Breast Carcinoma.

(Hills N, Leslie M, Davis R, Crowell M, Kameyama H, Rui H, Chervoneva I, Dooley W, Tanaka T.) Ann Surg Oncol. 2021 Mar 21 PMID: 33748899 PMCID: PMC7982278 03/23/2021
ASO Author Reflections: Does Prompt Breast-Conserving Surgery Matter?

(Hills N, Leslie M, Davis R, Crowell M, Kamemyama H, Rui H, Chervoneva I, Dooley W, Tanaka T.) Ann Surg Oncol. 2021 Mar 05 PMID: 33666812 03/06/2021
Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells

(Rädler PD, Wehde BL, Triplett AA, Shrestha H, Shepherd JH, Pfefferle AD, Rui H, Cardiff RD, Perou CM, Wagner KU.) Nature Communications. December 2021;12(1) SCOPUS ID: 2-s2.0-85108162441 12/01/2021
The membrane-associated form of cyclin D1 enhances cellular invasion.

(Chen K, Jiao X, Ashton A, Di Rocco A, Pestell TG, Sun Y, Zhao J, Casimiro MC, Li Z, Lisanti MP, McCue PA, Shen D, Achilefu S, Rui H, Pestell RG.) Oncogenesis. 2020 Sep 18;9(9):83 PMID: 32948740 PMCID: PMC7501870 SCOPUS ID: 2-s2.0-85091177817 09/20/2020
Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis.

(Cho C, Mukherjee R, Peck AR, Sun Y, McBrearty N, Katlinski KV, Gui J, Govindaraju PK, Puré E, Rui H, Fuchs SY.) Oncogene. 2020 09;39(38):6129-6137 PMID: 32807917 PMCID: PMC7502515 SCOPUS ID: 2-s2.0-85089539324 08/19/2020
Individualized multi-omic pathway deviation scores using multiple factor analysis.

(Rau A, Manansala R, Flister MJ, Rui H, Jaffrézic F, Laloë D, Auer PL.) Biostatistics. 2020 Aug 06 PMID: 32766691 08/09/2020
Malignant cell-specific pro-tumorigenic role of type I interferon receptor in breast cancers.

(Odnokoz O, Yu P, Peck AR, Sun Y, Kovatich AJ, Hooke JA, Hu H, Mitchell EP, Rui H, Fuchs SY.) Cancer Biol Ther. 2020 07 02;21(7):629-636 PMID: 32378445 PMCID: PMC7515508 SCOPUS ID: 2-s2.0-85084376942 05/08/2020
Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury.

(Schlaak RA, Frei A, Fish BL, Harmann L, Gasperetti T, Pipke JL, Sun Y, Rui H, Flister MJ, Gantner BN, Bergom C.) Cancers (Basel). 2020 Apr 16;12(4) PMID: 32316187 PMCID: PMC7226421 04/23/2020

Hallgeir Rui, MD, PhD