
Jack Gorski, PhD
Senior Investigator, Versiti Blood Research Institute; Assistant Professor, Microbiology & Immunology; Director, Center for Human Immunology
Locations
- Versiti Blood Research Institute
Blood Center of Wisconsin
Contact Information
General Interests
Education
Research Interests
I am interested in understanding the molecular basis of T cell immunity in man, focusing on polymorphism and variability within this system. Work in my lab has involved one to many to one mapping of the principle components of the system: the MHC, antigen peptide, and TCR. We have been interested in the biophysics of binding of multiple peptides to a single class II MHC molecule, as well as the ability of a single peptide to bind multiple class II MHC. Similarly we have a strong interest in the biophysics of many TCR interacting with a single peptide-MHC complex as well as the T cell cross-reactivity (one TCR binding many peptide-MHC complexes). There has been a special emphasis on describing and understanding the long term memory requirements post-thymic involution. This interest has led to molecular analyses of T cell repertoires and the role of cross-reactivity in maintaining immunity as well as providing a selectable population of responders when a new antigen peptide is encountered. Currently we are focusing on possible intrinsic differences in rearrangement of TCR and BCR as evidenced from NGS analysis of circulating and thymic repertoires. Together with Dr. Martin Hessner, we have developed an interest in human plasma/serum as an indicator of overall immune status in an individual.
Publications
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Structural and Mechanistic Implications of Rearrangement Frequencies within Human TCRBV Genes.
(Yassai MB, Demos W, Gorski J.) J Immunol. 2017 08 01;199(3):1142-1152 PMID: 28659354 PMCID: PMC5659713 SCOPUS ID: 2-s2.0-85026198299 07/01/2017
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(Lo CY, Strobl SL, Dunham K, Wang W, Stewart L, Misplon JA, Garcia M, Gao J, Ozawa T, Price GE, Navidad J, Gradus S, Bhattacharyya S, Viboud C, Eichelberger MC, Weiss CD, Gorski J, Epstein SL.) Open Forum Infect Dis. 2017;4(2):ofx023 PMID: 28730155 PMCID: PMC5510460 07/22/2017
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CDR3 motif generation and selection in the BV19-utilizing subset of the human CD8 T cell repertoire.
(Yassai MB, Demos W, Gorski J.) Mol Immunol. 2016 Apr;72:57-64 PMID: 26963408 PMCID: PMC5045866 SCOPUS ID: 2-s2.0-84959490724 03/11/2016
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CDR3 clonotype and amino acid motif diversity of BV19 expressing circulating human CD8 T cells.
(Yassai MB, Demos W, Janczak T, Naumova EN, Gorski J.) Hum Immunol. 2016 Jan;77(1):137-145 PMID: 26593155 PMCID: PMC4896086 SCOPUS ID: 2-s2.0-84969375503 11/26/2015
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(Zhou V, Yassai MB, Regunathan J, Box J, Bosenko D, Vashishath Y, Demos W, Lee F, Gorski J.) Hum Immunol. 2013 Jul;74(7):809-17 PMID: 23295548 PMCID: PMC3665722 SCOPUS ID: 2-s2.0-84878599971 01/09/2013
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(Levy H, Wang X, Kaldunski M, Jia S, Kramer J, Pavletich SJ, Reske M, Gessel T, Yassai M, Quasney MW, Dahmer MK, Gorski J, Hessner MJ.) Genes Immun. 2012 Dec;13(8):593-604 PMID: 22972474 PMCID: PMC4265236 SCOPUS ID: 2-s2.0-84870911405 09/14/2012
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(Petrova GV, Gorski J.) Eur J Immunol. 2012 Nov;42(11):3001-8 PMID: 22865108 PMCID: PMC3817827 SCOPUS ID: 2-s2.0-84868128246 08/07/2012
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Deviations in influenza seasonality: odd coincidence or obscure consequence?
(Moorthy M, Castronovo D, Abraham A, Bhattacharyya S, Gradus S, Gorski J, Naumov YN, Fefferman NH, Naumova EN.) Clin Microbiol Infect. 2012 Oct;18(10):955-62 PMID: 22958213 PMCID: PMC3442949 SCOPUS ID: 2-s2.0-84866175588 09/11/2012
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(Relland LM, Williams JB, Relland GN, Haribhai D, Ziegelbauer J, Yassai M, Gorski J, Williams CB.) J Immunol. 2012 Oct 01;189(7):3566-74 PMID: 22933635 PMCID: PMC3538134 SCOPUS ID: 2-s2.0-84866532545 08/31/2012
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Cross-reactivity of T cells and its role in the immune system.
(Petrova G, Ferrante A, Gorski J.) Crit Rev Immunol. 2012;32(4):349-72 PMID: 23237510 PMCID: PMC3595599 SCOPUS ID: 2-s2.0-84871332199 12/15/2012
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Developmental dynamics of post-selection thymic DN iNKT.
(Yassai M, Cooley B, Gorski J.) PLoS One. 2012;7(8):e43509 PMID: 22927977 PMCID: PMC3425480 SCOPUS ID: 2-s2.0-84865161299 08/29/2012
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(Ferrante A, Gorski J.) Sci Rep. 2012;2:386 PMID: 22545194 PMCID: PMC3338121 05/01/2012