Jack Gorski, PhD
Senior Investigator, Blood Research Institute, BloodCenter of Wisconsin; Assistant Professor, Microbiology & Immunology; Director, Center for Human Immunology
Locations
- Blood Research Institute
BloodCenter of Wisconsin
Contact Information
Biography
General Interests
Human Immunology
Education
Developmental Biology, University of Cincinnati, 1976
Research Interests
I am interested in understanding the molecular basis of T cell immunity in man, focusing on polymorphism and variability within this system. Work in my lab has involved one to many to one mapping of the principle components of the system: the MHC, antigen peptide, and TCR. We have been interested in the biophysics of binding of multiple peptides to a single class II MHC molecule, as well as the ability of a single peptide to bind multiple class II MHC. Similarly we have a strong interest in the biophysics of many TCR interacting with a single peptide-MHC complex as well as the T cell cross-reactivity (one TCR binding many peptide-MHC complexes). There has been a special emphasis on describing and understanding the long term memory requirements post-thymic involution. This interest has led to molecular analyses of T cell repertoires and the role of cross-reactivity in maintaining immunity as well as providing a selectable population of responders when a new antigen peptide is encountered. Currently we are focusing on possible intrinsic differences in rearrangement of TCR and BCR as evidenced from NGS analysis of circulating and thymic repertoires. Together with Dr. Martin Hessner, we have developed an interest in human plasma/serum as an indicator of overall immune status in an individual.
Publications
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(Lo CY, Strobl SL, Dunham K, Wang W, Stewart L, Misplon JA, Garcia M, Gao J, Ozawa T, Price GE, Navidad J, Gradus S, Bhattacharyya S, Viboud C, Eichelberger MC, Weiss CD, Gorski J, Epstein SL.) Open Forum Infect Dis. 2017;4(2):ofx023.
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Structural and Mechanistic Implications of Rearrangement Frequencies within Human TCRBV Genes.
(Yassai MB, Demos W, Gorski J.) J Immunol. 2017 08 01;199(3):1142-1152.
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CDR3 motif generation and selection in the BV19-utilizing subset of the human CD8 T cell repertoire.
(Yassai MB, Demos W, Gorski J.) Mol Immunol. 2016 Apr;72:57-64.
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CDR3 clonotype and amino acid motif diversity of BV19 expressing circulating human CD8 T cells.
(Yassai MB, Demos W, Janczak T, Naumova EN, Gorski J.) Hum Immunol. 2016 Jan;77(1):137-145.
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(Zhou V, Yassai MB, Regunathan J, Box J, Bosenko D, Vashishath Y, Demos W, Lee F, Gorski J.) Hum Immunol. 2013 Jul;74(7):809-17.
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Cross-reactivity of T cells and its role in the immune system.
(Petrova G, Ferrante A, Gorski J.) Crit Rev Immunol. 2012;32(4):349-72.
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(Levy H, Wang X, Kaldunski M, Jia S, Kramer J, Pavletich SJ, Reske M, Gessel T, Yassai M, Quasney MW, Dahmer MK, Gorski J, Hessner MJ.) Genes Immun. 2012 Dec;13(8):593-604.
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Deviations in influenza seasonality: odd coincidence or obscure consequence?
(Moorthy M, Castronovo D, Abraham A, Bhattacharyya S, Gradus S, Gorski J, Naumov YN, Fefferman NH, Naumova EN.) Clin Microbiol Infect. 2012 Oct;18(10):955-62.
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(Relland LM, Williams JB, Relland GN, Haribhai D, Ziegelbauer J, Yassai M, Gorski J, Williams CB.) J Immunol. 2012 Oct 01;189(7):3566-74.
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Developmental dynamics of post-selection thymic DN iNKT.
(Yassai M, Cooley B, Gorski J.) PLoS One. 2012;7(8):e43509.
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(Petrova GV, Gorski J.) Eur J Immunol. 2012 Nov;42(11):3001-8.
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(Ferrante A, Gorski J.) Sci Rep. 2012;2:386.