Staff Collaborate Conference Room

Jason Siebert, PhD

Jason Siebert

Jason Siebert, PhD

M4 Student

Faculty Advisor

  • Subramanian Malarkannan, PhD, Blood Research Institute

Locations

  • Medical Scientist Training Program

Contact Information

Education

PhD, Medical College of Wisconsin, 2019
BS, Biochemistry and Molecular Biology, Michigan State University, 2012

Research Interests

The role of the CBM signalosome in the NFκB signaling pathway and utilizing this information to improve NK cell CAR function

Research Experience

Medical College of Wisconsin, 2014-2019
Advisor: Subramaniam Malarkannan, PhD
Project: Requirement of ADAP-Carma1 signaling axis in NK cell-mediated effector functions

Michigan State University
Advisor: Eric Hegg, PhD
Project: Assembly and Functional Importance of Cytochrome C Oxidase Assembly Factors

Northwestern University
Advisor: Robert Schleimer, PhD
Project: Role of Aspergillus Fumigatus Toxin in Skewing the Th1/Th2 response

Publications

Yang C, Siebert JR, Burns R, et al. Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature. Elife. 2020;9:e51339. Published 2020 May 14. doi:10.7554/eLife.51339

Yang C, Siebert JR, Burns R, et al. Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome. Nat Commun. 2019;10(1):3931. Published 2019 Sep 2. doi:10.1038/s41467-019-11947-7

Abel AM, Tiwari AA, Gerbec ZJ,Siebert JR, et al. IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells. Front Immunol. 2018;9:1168. Published 2018 May 28. doi:10.3389/fimmu.2018.01168

General Interests

I enjoy snowboarding, attending concerts and reading.