Jing Liu, PhD
Graduate Student, Integrated Biomedical Sciences (IBS) PhD program, University of Kentucky, Lexington, KY, 2012
Bachelor of Medicine (MD equivalent), Peking University Health Science Center, Beijing, China, 2010
I was trained with Dr. Alan Daugherty at the University of Kentucky for my PhD degree. My dissertation research focused on determining the role various lipoprotein fractions in the pathogenesis of angiotensin II-induced abdominal aortic aneurysm (AAA). In February 2016, I joined Dr. Kaikobad Irani at the University of Iowa for my postdoctoral training to determine the role microRNA-204 in aortic aneurysm and metabolic disorders. My current research in Dr. Mingyu Liang laboratory aims to understand the role of miR-204 in vasculature and kidney and its potential targets in regulating vascular function, renal injury and blood pressure. My immediate goal is to obtain career development grants on this topic. My long-term goal is to pursue an independent career in vascular biology and hypertension research.
Cheng Y, Wang D, Wang F, Liu J, Huang B, Baker MA, Yin J, Wu R, Liu X, Regner KR, Usa K, Liu Y, Zhang C, Dong L, Geurts AM, Wang N, Miller SS, He Y, Liang M. Endogenous miR-204 protects the kidney against chronic injury in hypertension and diabetes. J Am Soc Nephrol 2020 Jul;31(7):1539-1554. Doi: 10.1681/ASN.2019101100
Liu J, Lu H, Moorleghen JJ, Howatt DA, Balakrishnan A, Daugherty A. Hypercholesterolemia accelerates both the initiation and progression of angiotensin II-induced abdominal aortic aneurysms. Ann Vasc Med Res. 2020 Jan; 7(1): 1099.
Liu J*, Kassan M*, Gabani M, Kim YR, Li Q, Kumar S, Vikram A, Jacobs J, Irani K. MicroRNA-204 promotes browning of white adipose tissue through colonic serotonin. 2020 Manuscript in Preparation. * These authors contributed equally.
Liu J, Kim YR, Gabani M, Kassan M, Li Q, Kumar S, Jacobs JS, Irani K. MicroRNA-204 protects mice from angiotensin II-Induced ascending aortic aneurysm. 2020 Manuscript in Revision (ATVB/2018/312342)
Kim YR, Jacobs J, Li Q, Gaddam R, Vikram A, Liu J, Kassan M, Irani K, and Kumar S. SUMO2 impairs endothelial function and induces vascular oxidative stress in mice. Am J Physiol Heart Circ Physiol. 2019 Oct; 317 (6): H1292-H1300. PMID: 31584834.
Gabani M, Liu J, Ait-Aissa K, Koval O, Kim YR, Castañeda D, Vikram A, Jacobs JS, Grumbach I, Trebak M, Irani K, Kassan M. MiR-204 regulates type 1 IP3R to control vascular smooth muscle cell contractility and blood pressure. Cell Calcium. 2019 Jun; 80: 18-24. PMID: 30925290
Liu J, Wu J. Tumour necrosis factor α sets area postrema on fire in renovascular hypertension. Cardiovasc Res. 2019 May 1;115(6):995-997. Doi: 10.1093/cvr/cvz011.
Kassan M, Vikram A, Li Q, Kim YR, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K. MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1. Scientific Reports. 2017 Aug;7(1):9308. PMID: 28839162.
Vikram A, Lewarchik CM, Yoon JY, Naqvi A, Kumar S, Morgan G,. Jacobs JS, Li Q, Kim YR, Kassan M, Liu J, Gabani M, Kuma A, Mehdi H, Zhu X, Guan X, Kutschke W, Zhang X, Boudreau R, Dai S, Matasic D, Jung SB, Margulies KB, Kumar V, Bachschmid MM, London B, Irani K. Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel. Nature Medicine. 2017 Mar; 23(3): 361-367. PMID: 28191886.
Kassan M, Vikram A, Kim YR, Li Q, Kassan A, Patel H, Kumar S, Gabani M, Liu J, Jacobs J, and Irani K. Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress. Scientific Reports. 2017 Feb; 7: 42265. PMID: 28181559
Liu J, Lu H, Howatt DA, Balakrishnan A, Moorleghen JJ, Sorci-Thomas M, Cassis LA, Daugherty A. Associations of ApoAI and ApoB-containing lipoproteins with AngII-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2015 Aug; 35(8): 1826-34. PMID: 26044581
Liu J, Daugherty A, Lu H. Angiotensin II and abdominal aortic aneurysms: An update. Current Pharmaceutical Design. 2015 Aug; 21(28): 4035-48. PMID: 26306840
Honors and Awards
May 2015 - Outstanding Presentation Award, CAAC-MPVB Metabolic Vascular Disease Symposium, AHA ATVB Council, San Francisco, CA
2015-2016 - Graduate School Travel Award, University of Kentucky
2014-2015 - Kentucky Opportunity Fellowship ($15,000), Lexington, KY
2014-2015 - Graduate School Travel Award, University of Kentucky
2007-2008 - Peking University Scholarship for Outstanding Medical Student, Peking University Health Science Center, Beijing China