Jing Pan, PhD

Assistant Professor

Locations

Pharmacology and Toxicology

Contact Information

Biography

General Interests

Lung Cancer and Chemoprevention

Education

PhD, Cell Biology, Lanzhou University, 2005
BS, Biochemistry, Lanzhou University, 2000

Research Interests

My primary research interest is in chemoprevention and immune-prevention of lung cancer with either natural compound or synthetic peptides. Cancer immune-prevention is currently undergoing exponential growth. Peptide vaccination against tumor-associated antigen as a means of treating cancer patients or preventing the development of tumors in high-risk individuals is currently an area of intense research. Peptide vaccines can elicit memory T cells that remain in lymph nodes until exposed to the target antigen. My goal is to develop effective peptide vaccines to prevent cancer development and progression. We currently employed longer peptides with predicted binding affinity to MHC class II. Using this approach, we successfully developed a series of multipeptide multivalent vaccine that elicited robust Th1 immune responses and effectively blocked the development of lung cancers in multiple mouse models.

Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine.

(Pan J, Zhang Q, Sei S, Shoemaker RH, Lubet RA, Wang Y, You M.) Oncotarget. 2017 Oct 10;8(47):82689-82699.
Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer.

(Zhang Q, Li R, Chen X, Lee SB, Pan J, Xiong D, Hu J, Miller MS, Szabo E, Lubet RA, Wang Y, You M.) Oncotarget. 2017 Sep 22;8(42):72447-72456.
Pioglitazone-mediated reversal of elevated glucose metabolism in the airway epithelium of mouse lung adenocarcinomas.

(Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M.) JCI Insight. 2017 Jul 06;2(13).
Rad52 deficiency decreases development of lung squamous cell carcinomas by enhancing immuno-surveillance.

(Lieberman R, Pan J, Zhang Q, You M.) Oncotarget. 2017 May 23;8(21):34032-34044.
Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.

(Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, You M, Wang Y.) Oncotarget. 2017 Mar 21;8(12):18885-18900.
Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway.

(Pan J, Lee Y, Zhang Q, Xiong D, Wan TC, Wang Y, You M.) Cancer Prev Res (Phila). 2017 Feb;10(2):133-141.
miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1.

(Wang Y, Lieberman R, Pan J, Zhang Q, Du M, Zhang P, Nevalainen M, Kohli M, Shenoy NK, Meng H, You M, Wang L.) Mol Cancer. 2016 11 10;15(1):70.
Honokiol targets mitochondria to halt cancer progression and metastasis.

(Pan J, Lee Y, Wang Y, You M.) Mol Nutr Food Res. 2016 06;60(6):1383-95.
Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro.

(Zhang Q, Pan J, Lubet RA, Komas SM, Kalyanaraman B, Wang Y, You M.) Cancer Prev Res (Phila). 2015 Apr;8(4):318-26.
Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function.

(Pan J, Zhang Q, Liu Q, Komas SM, Kalyanaraman B, Lubet RA, Wang Y, You M.) Cancer Prev Res (Phila). 2014 Nov;7(11):1149-59.
Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention.

(Zhang Q, Pan J, Lubet RA, Wang Y, You M.) Mol Carcinog. 2015 Jun;54 Suppl 1:E129-37.
Transcriptomic analysis by RNA-seq reveals AP-1 pathway as key regulator that green tea may rely on to inhibit lung tumorigenesis.

(Pan J, Zhang Q, Xiong D, Vedell P, Yan Y, Jiang H, Cui P, Ding F, Tichelaar JW, Wang Y, Lubet RA, You M.) Mol Carcinog. 2014 Jan;53(1):19-29.

Jing Pan, PhD

Jing Pan, PhD

Assistant Professor

Locations

Contact Information

Biography

General Interests

Education

Research Interests

Publications