Jing Pan, PhD

Assistant Professor

Locations

Pharmacology and Toxicology

Contact Information

General Interests

Lung Cancer and Chemoprevention

Education

PhD, Cell Biology, Lanzhou University, 2005
BS, Biochemistry, Lanzhou University, 2000

Research Interests

My primary research interest is in chemoprevention and immune-prevention of lung cancer with either natural compound or synthetic peptides. Cancer immune-prevention is currently undergoing exponential growth. Peptide vaccination against tumor-associated antigen as a means of treating cancer patients or preventing the development of tumors in high-risk individuals is currently an area of intense research. Peptide vaccines can elicit memory T cells that remain in lymph nodes until exposed to the target antigen. My goal is to develop effective peptide vaccines to prevent cancer development and progression. We currently employed longer peptides with predicted binding affinity to MHC class II. Using this approach, we successfully developed a series of multipeptide multivalent vaccine that elicited robust Th1 immune responses and effectively blocked the development of lung cancers in multiple mouse models.

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.

(Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, Chen G, Kresty L, Kalyanaraman B, You M.) Nat Commun. 2019 05 17;10(1):2205.
Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice.

(Zhang Q, Lee SB, Chen X, Stevenson ME, Pan J, Xiong D, Zhou Y, Miller MS, Lubet RA, Wang Y, Mirza SP, You M.) Nano Lett. 2019 04 10;19(4):2231-2242.
Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma.

(Pan J, Xiong D, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M.) Sci Rep. 2018 06 11;8(1):8895.
Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity.

(Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M.) iScience. 2018 May 25;3:192-207.
Novel mutational landscapes and expression signatures of lung squamous cell carcinoma.

(Xiong D, Pan J, Yin Y, Jiang H, Szabo E, Lubet RA, Wang Y, You M.) Oncotarget. 2018 Jan 26;9(7):7424-7441.
Isolation and Characterization of a Chinese Hamster Ovary Heparan Sulfate Cell Mutant Defective in Both Met Receptor Binding and Hepatocyte Growth Factor NK1/Met Signaling.

(Cao T, Pan J, Li X, He Y, Jiang Y, Chang Y, Zhang Q, Lan Y, Wang H, Jiao W, Tian Z, Zhang L.) Cell Physiol Biochem. 2018;48(4):1480-1491.
Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine.

(Pan J, Zhang Q, Sei S, Shoemaker RH, Lubet RA, Wang Y, You M.) Oncotarget. 2017 Oct 10;8(47):82689-82699.
Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer.

(Zhang Q, Li R, Chen X, Lee SB, Pan J, Xiong D, Hu J, Miller MS, Szabo E, Lubet RA, Wang Y, You M.) Oncotarget. 2017 Sep 22;8(42):72447-72456.
Pioglitazone-mediated reversal of elevated glucose metabolism in the airway epithelium of mouse lung adenocarcinomas.

(Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M.) JCI Insight. 2017 Jul 06;2(13).
Rad52 deficiency decreases development of lung squamous cell carcinomas by enhancing immuno-surveillance.

(Lieberman R, Pan J, Zhang Q, You M.) Oncotarget. 2017 May 23;8(21):34032-34044.
Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.

(Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, You M, Wang Y.) Oncotarget. 2017 Mar 21;8(12):18885-18900.
Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway.

(Pan J, Lee Y, Zhang Q, Xiong D, Wan TC, Wang Y, You M.) Cancer Prev Res (Phila). 2017 Feb;10(2):133-141.

Jing Pan, PhD

Jing Pan, PhD

Assistant Professor

Locations

Contact Information

General Interests

Education

Research Interests

Publications