Katelyn Sadler, PhD

Education

PhD, Biological Sciences, Duquesne University, 2017
BS, Biological Sciences, University of Pittsburgh, 2011

Faculty Advisor

Cheryl L. Stucky, PhD

Molecular and cellular mechanisms underlying sickle cell disease pain
Approximately 100,000 Americans suffer from a genetic blood disorder known as sickle cell disease (SCD). Under stress, dehydration, and reduced oxygen conditions, SCD patients experience intense pain crises that often lead to hospitalization. In addition to these acute crises, approximately 40% of SCD patients also develop persistent chronic pain as the disease progresses. In my research, I am investigating the neurobiological mechanisms, particularly those of the peripheral nervous system, that mediate the acute and chronic pain associated with SCD as well as the transition between the two states.

2018 Achievements

Awards
Kate was recently awarded an NINDS Ruth L. Kirchstein National Research Service Award (NRSA) for Training of Postdoctoral Fellows (F32). Kate’s proposal entitled “Fibroblast-to-neuron communication in muscle pain” will explore the extent and mechanisms through which muscle support cells communicate with sensory neurons to relay both painful and non-painful signals to the central nervous system. This unique award is presented to promising, early-stage postdoctoral fellows and will fund Kate’s position until January 2020.

Upcoming meetings
Kate has been selected to participate in the 2018 North American Pain School. The meeting will be held in Quebec from June 24-28 and will bring together basic and clinical pain trainees from the US and Canada. Read more on the North American Pain School site.