Immune Regulation Mediated by Negative Checkpoint Regulators and Cancer Immunotherapy
PhD, Biochemistry, Dartmouth Medical School, 2003
Lab lunch outside on terrace (5-23-18)
Research in the Wang lab focuses on immune regulation mediated by the immune-checkpoint proteins, such as VISTA. We apply preclinical tumor models to investigate the mechanisms whereby VISTA controls the anti-tumor immunity, and design innovative immunotherapeutic strategies for cancer treatment.
Figure 1. The B7 family co-signaling molecules regulate T cell responses. The co-inhibitory molecules, such as CTLA-4, PD-1, and VISTA are also called "immune-checkpoints". They play critical role in maintaining T cell peripheral tolerance and controlling autoimmunity.
Figure 2. Research in the Wang lab addresses the immune-regulatory role of a novel immune-checkpoint molecule, called V-domain Immunoglobulin Suppression of T cell Activation (VISTA). VISTA is expressed on multiple immune cell types, and suppresses the anti-tumor immunity.
Figure 3. VISTA-blocking monoclonal antibody effectively enhances tumor-reactive T cell response, and can synergize with cancer vaccine to eradicate tumor cells.