Staff Collaborate Conference Room

Li Lily Wang, PhD

LiLilyWang

Li Lily Wang, PhD

Associate Professor

Locations

  • Microbiology & Immunology
    BSB 204

Contact Information

Biography

General Interests

Immune Regulation Mediated by Negative Checkpoint Regulators and Cancer Immunotherapy

Education

PhD, Biochemistry, Dartmouth Medical School, 2003

Research Interests

WangLabMembers
Lab lunch outside on terrace (5-23-18)

Wang Laboratory

Research in the Wang lab focuses on immune regulation mediated by the immune-checkpoint proteins, such as VISTA. We apply preclinical tumor models to investigate the mechanisms whereby VISTA controls the anti-tumor immunity, and design innovative immunotherapeutic strategies for cancer treatment.

b7tcellimmunecheckpoints

Figure 1. The B7 family co-signaling molecules regulate T cell responses.  The co-inhibitory molecules, such as CTLA-4, PD-1, and VISTA are also called "immune-checkpoints".  They play critical role in maintaining T cell peripheral tolerance and controlling autoimmunity.

wanglabresearchantitumorimmunity

Figure 2. Research in the Wang lab addresses the immune-regulatory role of a novel immune-checkpoint molecule, called V-domain Immunoglobulin Suppression of T cell Activation (VISTA). VISTA is expressed on multiple immune cell types, and suppresses the anti-tumor immunity.

vistablockingantibodycancervaccine

Figure 3. VISTA-blocking monoclonal antibody effectively enhances tumor-reactive T cell response, and can synergize with cancer vaccine to eradicate tumor cells.

Literature for Cancer Immunotherapy
Nature Cancer Immunotherapy
Tumour Immunology & Immunotherapy
Nature Reviews Cancer

Publications