Immune Regulation Mediated by Negative Checkpoint Regulators and Cancer Immunotherapy
PhD, Biochemistry, Dartmouth Medical School, 2003
Lab lunch outside on terrace (5-23-18)
Research in the Wang lab focuses on immune regulation mediated by the immune-checkpoint proteins, such as VISTA. We apply preclinical tumor models to investigate the mechanisms whereby VISTA controls the anti-tumor immunity, and design innovative immunotherapeutic strategies for cancer treatment.
Figure 1. The B7 family co-signaling molecules regulate T cell responses. The co-inhibitory molecules, such as CTLA-4, PD-1, and VISTA are also called "immune-checkpoints". They play critical role in maintaining T cell peripheral tolerance and controlling autoimmunity.
Figure 2. Research in the Wang lab addresses the immune-regulatory role of a novel immune-checkpoint molecule, called V-domain Immunoglobulin Suppression of T cell Activation (VISTA). VISTA is expressed on multiple immune cell types, and suppresses the anti-tumor immunity.
Figure 3. VISTA-blocking monoclonal antibody effectively enhances tumor-reactive T cell response, and can synergize with cancer vaccine to eradicate tumor cells.
(Xu W, Hiếu T, Malarkannan S, Wang L.) Cell Mol Immunol. 2018 May;15(5):438-446.
(Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L.) Sci Rep. 2017 05 03;7(1):1485.
Selective Involvement of the Checkpoint Regulator VISTA in Suppression of B-Cell, but Not T-Cell, Responsiveness by Monocytic Myeloid-Derived Suppressor Cells from Mice Infected with an Immunodeficiency-Causing Retrovirus.
(Green KA, Wang L, Noelle RJ, Green WR.) J Virol. 2015 Sep;89(18):9693-8.
(Imai Y, Ayithan N, Wu X, Yuan Y, Wang L, Hwang ST.) J Immunol. 2015 Jul 15;195(2):421-5.
(Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller HE, Guleria I, Barth RJ, Huang YH, Wang L.) Proc Natl Acad Sci U S A. 2015 May 26;112(21):6682-7.
(Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ.) Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14846-51.
(Lines JL, Sempere LF, Broughton T, Wang L, Noelle R.) Cancer Immunol Res. 2014 Jun;2(6):510-7.
(Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L.) Cancer Res. 2014 Apr 01;74(7):1933-44.
(Lines JL, Pantazi E, Mak J, Sempere LF, Wang L, O'Connell S, Ceeraz S, Suriawinata AA, Yan S, Ernstoff MS, Noelle R.) Cancer Res. 2014 Apr 01;74(7):1924-32.
(Randolph J Noelle, Li Wang.) . .
(Wang L, Rubinstein R, Lines JL, Wasiuk A, Ahonen C, Guo Y, Lu LF, Gondek D, Wang Y, Fava RA, Fiser A, Almo S, Noelle RJ.) J Exp Med. 2011 Mar 14;208(3):577-92.
(Wang L.) Methods Mol Biol. 2010;595:403-12.