Staff Collaborate Conference Room

Linda Berg Luecke

Linda BergLuecke

Linda Berg Luecke

G4 Student

Faculty Advisor

  • Rebekah Gundry, PhD

Locations

  • Medical Scientist Training Program

Contact Information

Education

MS, Chemistry, University of Dayton, 2012
BS, Chemistry, Carroll University, 2010

Research Interests

Mass Spectrometry, Cell Surface Glycoproteins in Advanced Heart Failure

Research Experience

Medical College of Wisconsin, 2018-present
Advisor: Rebekah Gundry, PhD
Project: Cell surface and extracellular glycoproteins in advanced heart failure (7/1/2019-6/302020: CTSI, TL1 7/1/2020-6/30/2020: AHA predoctoral fellowship)

MD Anderson Cancer Center
Advisor: Raghu Kalluri, MD, PhD, 2013-2014
Project: Biology of exosomes and their association with cancer development and metastasis. Tumor-derived exosomes’ utility as circulating biomarker in early detection of cancer.

Versiti Blood Center of Wisconsin, Blood Research Institute
Advisor: Subramaniam Malarkannan, PhD, 2014-2016
Project: Chimeric Antigen Receptor (CAR)-based NK cell-mediated cellular immunotherapy.

Publications

Whyte ML, Smith K, Buchberger A, Berg Luecke L, et al. The roseoloviruses downregulate the protein tyrosine phosphatase PTPRC (CD45). J Virol. 2021 May 5:JVI.01628-20. doi: 10.1128/JVI.01628-20. Epub ahead of print. PMID: 33952641.

Wojtkiewicz M, Berg Luecke L, Kelly MI, Gundry RL. Facile Preparation of Peptides for Mass Spectrometry Analysis in Bottom-Up Proteomics Workflows. Curr Protoc. 2021 Mar;1(3):e85. doi: 10.1002/cpz1.85. PMID: 33750040; PMCID: PMC8011989.

Berg Luecke L, Gundry RL. Assessment of Streptavidin Bead Binding Capacity to Improve Quality of Streptavidin-based Enrichment Studies. J Proteome Res. 2021 Feb 5;20(2):1153-1164. doi: 10.1021/acs.jproteome.0c00772. Epub 2020 Dec 3. PMID: 33270449.

Berg Luecke L, Waas M, Gundry RL Reliable Protocols for Flow Cytometry Analysis of Intracellular Proteins in Pluripotent Stem Cell Derivatives: A Fit-For-Purpose Approach. Current Protocols in Stem Cell Biology, 2019 Sep;50(1):e94, 2019. PMID: 31479597

Melo S.A., Luecke, L.B., Kahlert, C., Fernandez, A., Gammon, S.T, Kaye J., LeBleu, V.S, Mittendorf E.A., Weitz J., Rahbari N., Reissfelder, C., Fraga, M., Piwnica-Worms, D. and Kalluri, K. (2015). Identification of GPC1 as a Specific Biomarker for Circulating Cancer Exosomes with Utility for Detection of Early Stage Pancreas Cancer. Nature 523, 177-182.

Sunchu, B., Berg, L., Ward, H. E., Lopper, M. E. (2012). Identification of a small molecule PriA helicase inhibitor. Biochemistry 51, 10137-46.

Meeting Abstracts

Assessment of Streptavidin Bead Binding Capacity to Improve Quality of Streptavidin-based Enrichment Studies. (October 2020) HUPO Connect 2020. Virtual.

Platform for semi-automated cell surface N-glycoprotein profiling of human primary cells reveals chamber-specific cardiomyocyte surface maps. 2020 American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics. ASMS Reboot. Houston, TX

Berg Luecke, L, Waas, M, Mahr, C, Gundry, RL (October 2019). Cell Surface and Extracellular Matrix Proteins in Advanced Heart Failure. Milwaukee Regional Research Forum 2019. Milwaukee, WI

Berg Luecke, L, Buchberger, AR, Waas, M, Mahr, C, Gundry, RL (June 2019). Applying a Quantitative, Cell Surface Glycoproteomic Approach to Understanding the Role of Human Cardiac Fibroblasts in Advanced Heart Failure. ASMB 2019 Workshop, Fibroblast: The Arbiters of Extracellular Matrix Remodeling. Charlottesville, VA

Berg Luecke, L, Buchberger, AR, Waas, M, Gundry, RL (June 2019). Applying a Cell Surface Glycoproteomic Approach to Understanding Phenotypic Changes Induced by Extended Culturing of Explanted Human Cardiac Fibroblasts. 2019 American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics. Atlanta, GA

Berg Luecke, L, Waas, M, Jones Lipinski, RA, Farris, S, Stempien-Otero, A, Mahr, C, Gundry, RL (October 2018). Mapping the human cardiac fibroblast surfaceome in non-failing and failing hearts reveals new glycoprotein targets for tracking and studying disease. 2018 Cardiovascular Center Research Retreat. Milwaukee, WI

General Interests

Spending time with family, traveling, yoga